Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy [PDF]
, 2020 Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility due to high-fat diets contributing to obesity and type 2 diabetes.
Andújar, Eloísa +7 more
core +1 more source
The role of metabolic remodeling in macrophage polarization and its effect on skeletal muscle regeneration [PDF]
, 2019 Macrophages are crucial for tissue homeostasis. Based on their activation, they might display classical/M1 or alternative/M2 phenotypes. M1 macrophages produce pro-inflammatory cytokines, reactive oxygen species (ROS), and nitric oxide (NO).
Alessio Torcinaro +13 more
core +1 more source
Tumor Biology, 2017 Development of colorectal cancer has been considered as a result of imbalance of pro- and anti-inflammatory intestinal microenvironment accompanied by macrophage recruitment.
Kejian Zou +5 more
doaj +1 more source
Lapachol inhibits glycolysis in cancer cells by targeting pyruvate kinase M2. [PDF]
PLoS ONE, 2018 Reliance on aerobic glycolysis is one of the hallmarks of cancer. Although pyruvate kinase M2 (PKM2) is a key mediator of glycolysis in cancer cells, lack of selective agents that target PKM2 remains a challenge in exploiting metabolic pathways for ...
Mani Shankar Babu +5 more
doaj +1 more source
Upregulated expression of pyruvate kinase M2 mRNA predicts poor prognosis in lung adenocarcinoma [PDF]
PeerJ, 2020 Background Pyruvate kinase M2 (PKM2) is critical regulator contributing to Warburg effect. However, the expression pattern and prognostic value of PKM2 remain unknown in lung adenocarcinoma (LUAD). The aim of this study is to clarify the prognostic value
Guiping Wang +4 more
doaj +2 more sources
miRNAs link metabolic reprogramming to oncogenesis [PDF]
, 2013 The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M +2 more
core +1 more source
The Role of Fecal M2-Pyruvate Kinase (M2-PK) in Colorectal Cancer Screening
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2017 Colorectal cancer is a malignancy with high incidence and mortality rate. The long carsinogenesis sequence from adenoma unto carsinoma enable early detection and screening as part of the management but until recently the commercialy available test has ...
Nur Chandra Bunawan +1 more
doaj +1 more source
Targeting Glycolysis with Epigallocatechin-3-Gallate Enhances the Efficacy of Chemotherapeutics in Pancreatic Cancer Cells and Xenografts. [PDF]
, 2019 Pancreatic cancer is a complex disease, in need of new therapeutic approaches. In this study, we explored the effect and mechanism of action of epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, alone and in combination with current ...
Hackman, Robert M +3 more
core +1 more source
Aerobic Glycolysis in the Retina: Functional Roles of Pyruvate Kinase Isoforms
Frontiers in Cell and Developmental Biology, 2020 One hundred years ago, Otto Heinrich Warburg observed that postmitotic retinal cells are the highest oxygen-consuming cells in the body. He compared these cells to actively growing mitotic tumor cells since both cells reprogram glucose for anabolic ...
Raju V. S. Rajala +3 more
doaj +1 more source
Journal of Advanced Research, 2021 Introduction: Inflammation is a key factor in myocardial ischemia/reperfusion (MI/R) injury. Targeting leucocyte-mediated inflammation is an important strategy for MI/R therapy.
Shan Lu +6 more
doaj +1 more source