Results 51 to 60 of about 51,864 (248)

Posttranslational Modifications of Pyruvate Kinase M2: Tweaks that Benefit Cancer

Frontiers in Oncology, 2018
Cancer cells rewire metabolism to meet biosynthetic and energetic demands. The characteristic increase in glycolysis, i.e., Warburg effect, now considered as a hallmark, supports cancer in various ways.
Gopinath Prakasam, Mohammad Askandar Iqbal, Rameshwar N. K. Bamezai, Sybille Mazurek   +3 more
doaj   +1 more source

Pyruvate Kinase M2 Promotes Prostate Cancer Metastasis Through Regulating ERK1/2-COX-2 Signaling

Frontiers in Oncology, 2020
Pyruvate kinase M2 (PKM2) is a key enzyme of glycolysis, which is highly expressed in many tumor cells, and has emerged as an important player in tumor progression and metastasis.
Wenjing Guo, Wenjing Guo, Zhishuai Zhang, Guihuan Li, Xiaoju Lai, Ruonan Gu, Ruonan Gu, Wanfu Xu, Hua Chen, Zhe Xing, Liping Chen, Jiabi Qian, Shiyuan Xu, Fangyin Zeng, Fan Deng   +14 more
doaj   +1 more source

In vivo metabolic imaging of Traumatic Brain Injury. [PDF]

, 2017
Complex alterations in cerebral energetic metabolism arise after traumatic brain injury (TBI). To date, methods allowing for metabolic evaluation are highly invasive, limiting our understanding of metabolic impairments associated with TBI pathogenesis ...
Chaumeil, Myriam M, Chou, Austin, Feng, Xi, Guglielmetti, Caroline, Krukowski, Karen, Najac, Chloe, Riparip, Lara-Kirstie, Rosi, Susanna   +7 more
core   +2 more sources

Modeling cancer metabolism on a genome scale [PDF]

, 2015
Cancer cells have fundamentally altered cellular metabolism that is associated with their tumorigenicity and malignancy. In addition to the widely studied Warburg effect, several new key metabolic alterations in cancer have been established over the last
Barbara Chaneton, Eyal Gottlieb, Eytan Ruppin, Keren Yizhak, Kiuru M, Li L, Lobo C, Som P, Vazquez‐Martin A   +8 more
core   +1 more source

Corrigendum: Pyruvate kinase M2 promotes prostate cancer metastasis through regulating ERK1/2-COX-2 signaling. [PDF]

Front Oncol
Guo W, Zhang Z, Li G, Lai X, Gu R, Xu W, Chen H, Xing Z, Chen L, Qian J, Xu S, Zeng F, Deng F.   +12 more
europepmc   +2 more sources

STAT3, a hub protein of cellular signaling pathways, is triggered by β-hexaclorocyclohexane [PDF]

, 2018
Background: Organochlorine pesticides (OCPs) are widely distributed in the environment and their toxicity is mostly associated with the molecular mechanisms of endocrine disruption.
Altieri, F, Carissimi, S, Chichiarelli, S, Eufemi, M, Giamogante, F, Macone, A, Paglia, G, Rubini, E   +7 more
core   +2 more sources

Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer

World Journal of Surgical Oncology, 2018
Background Expression of the dimeric M2 isoenzyme of pyruvate kinase, termed Tumor M2-PK, is increased in some human cancers. This study evaluates the potential role of pre-operative Tumor M2-PK as a marker of prognosis in patients with pancreatic ...
Indika A. Bandara, Minas Baltatzis, Sudip Sanyal, Ajith K. Siriwardena   +3 more
doaj   +1 more source

Sensor potency of the moonlighting enzyme-decorated cytoskeleton [PDF]

, 2013
Background: There is extensive evidence for the interaction of metabolic enzymes with the eukaryotic cytoskeleton. The significance of these interactions is far from clear.
Amar Patrick, Legent Guillaume, Norris Vic, Ovádi Judit, Ripoll Camille, Thellier Michel   +5 more
core   +4 more sources

Reciprocal Regulation of Protein Kinase and Pyruvate Kinase Activities of Pyruvate Kinase M2 by Growth Signals [PDF]

Journal of Biological Chemistry, 2013
Pyruvate kinase isoform M2 (PKM2) is an enzyme-catalyzing conversion of phosphoenolpyruvate to pyruvate in the glycolysis pathway. It was demonstrated that PKM2 interacts with tyrosine phosphopeptide, and the interaction with the tyrosine phosphopeptide affects the pyruvate kinase activity of PKM2.
Xueliang, Gao, Haizhen, Wang, Jenny J, Yang, Jing, Chen, Jiang, Jie, Liangwei, Li, Yinwei, Zhang, Zhi-Ren, Liu   +7 more
openaire   +2 more sources

2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase [PDF]

, 2011
Compared to normal differentiated cells, cancer cells have altered metabolic regulation to support biosynthesis and the expression of the M2 isozyme of pyruvate kinase (PKM2) plays an important role in this anabolic metabolism.
Auld, Douglas S., Bougie, James M., Boxer, Matthew B., Brimacombe, Kyle R., Cantley, Lewis C., Daniel, Thomas, Israelsen, William James, Leister, William, Shen, Min, Thomas, Craig J., Vander Heiden, Matthew G., Veith, Henrike, Walsh, Martin J.   +12 more
core   +1 more source