Results 11 to 20 of about 23,565 (226)
PKM2 is not required for pancreatic ductal adenocarcinoma [PDF]
Cancer & Metabolism, 2018 Background While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models.
Alissandra L Hillis +6 more
doaj +5 more sources
Cell-Type-Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance. [PDF]
FASEB JWe investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Rajala A +3 more
europepmc +2 more sources
Extracellular PKM2 facilitates organ-tissue fibrosis progression [PDF]
iScience, 2021 Persistent activation of fibroblasts and resistance of myofibroblasts to turnover play important roles in organ-tissue fibrosis development and progression. The mechanism that mediates apoptosis resistance of myofibroblasts is not understood. Here, we report that myofibroblasts express and secrete PKM2.
Hongwei Han +7 more
openaire +3 more sources
PKM2 Enters the Morpheein Academy [PDF]
Molecular Cell, 2012 In this issue of Molecular Cell, Gao et al. (2012) show that the glycolytic enzyme PKM2, in its dimeric form, possesses protein kinase activity and phosphorylates STAT3 in the nucleus, thereby driving expression of genes that promote transformation.
Semenova, Galina, Chernoff, Jonathan
openaire +2 more sources
PKM2, function and expression and regulation [PDF]
Cell & Bioscience, 2019 Pyruvate kinase (PK), as one of the key enzymes for glycolysis, can encode four different subtypes from two groups of genes, although the M2 subtype PKM2 is expressed mainly during embryonic development in normal humans, and is closely related to tissue repair and regeneration, with the deepening of research, the role of PKM2 in tumor tissue has ...
Ze Zhang +5 more
openaire +3 more sources
Nuclear PKM2 regulates the Warburg effect [PDF]
Cell Cycle, 2013 Pyruvate kinase is a rate-limiting glycolytic enzyme. The PKM1 and PKM2 isoforms result from mutually exclusive alternative splicing of the PKM pre-mRNA. PKM2 rather than PKM1 regulates the Warburg effect and tumorigenesis by poorly understood mechanisms.
Weiwei, Yang, Zhimin, Lu
openaire +2 more sources
Identification of a serum biomarker panel for the differential diagnosis of cholangiocarcinoma and primary sclerosing cholagnitis [PDF]
, 2018 The non-invasive differentiation of malignant and benign biliary disease is a clinical challenge. Carbohydrate antigen 19-9 (CA19-9), leucine-rich α2-glycoprotein (LRG1), interleukin 6 (IL6), pyruvate kinase M2 (PKM2), cytokeratin 19 fragment (CYFRA21.1)
Blyuss, O +9 more
core +2 more sources
Programming Skeletal Muscle Metabolic Flexibility in Offspring of Male Rats in Response to Maternal Consumption of Slow Digesting Carbohydrates during Pregnancy [PDF]
, 2020 Skeletal muscle plays a relevant role in metabolic flexibility and fuel usage and the associated muscle metabolic inflexibility due to high-fat diets contributing to obesity and type 2 diabetes.
Andújar, Eloísa +7 more
core +1 more source
PKM2 and cancer: The function of PKM2 beyond glycolysis
Oncology Letters, 2016 Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth.
DONG, GAOCHAO +6 more
openaire +3 more sources
Cancer & Metabolism, 2018 Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer.
Talya L. Dayton +7 more
doaj +1 more source