Results 31 to 40 of about 22,457 (246)
Dual roles of PKM2 in cancer metabolism [PDF]
Acta Biochimica et Biophysica Sinica, 2013 Cancer cells have distinct metabolism that highly depends on glycolysis instead of mitochondrial oxidative phosphorylation alone, known as aerobic glycolysis. Pyruvate kinase (PK), which catalyzes the final step of glycolysis, has emerged as a potential regulator of this metabolic phenotype.
Songfang, Wu, Huangying, Le
openaire +2 more sources
Shmt2: a stat3 signaling new player in prostate cancer energy metabolism [PDF]
, 2019 Prostate cancer (PCa) is a multifactorial disease characterized by the aberrant activity of different regulatory pathways. STAT3 protein mediates some of these pathways and its activation is implicated in the modulation of several metabolic enzymes.
Altieri, Fabio +14 more
core +1 more source
PKM2 functions as a histone kinase [PDF]
Cell Cycle, 2012 In the presence of oxygen, most differentiated cells generate the energy needed for cellular processes primarily by metabolizing glucose to carbon dioxide by oxidation of glycolytic pyruvate in the mitochondrial tricarboxylic acid cycle. When oxygen becomes limited, differentiated cells produce large amounts of lactate.
openaire +2 more sources
Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
Molecular & Cellular Oncology, 2018 Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target
Taku Sato +3 more
doaj +1 more source
PKM2 is not required for colon cancer initiated by APC loss
Cancer & Metabolism, 2017 Background Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor
Allison N. Lau +10 more
doaj +1 more source
Frontiers in Immunology, 2021 Toll-like receptors (TLRs) play critical roles in regulating the abnormal activation of the immune cells resulting in the pathogenesis of inflammation and autoimmune diseases.
Xin Zhang +22 more
doaj +1 more source
JAK-STAT, 2012 The M2 isoform of pyruvate kinase, highly expressed in tumor cells, is known to engage a feed forward loop with the glycolysis master transcription factor HIF-1α. Gao and co-authors recently showed that dimeric PKM2 localizes to the nucleus in highly proliferating cancer cells, where it regulates in vivo growth by acting as a protein kinase and ...
DEMARIA, MARCO, POLI, Valeria
openaire +2 more sources
Journal of Lipid Research, 2020 Pyruvate kinase M2 (PKM2) links metabolic and inflammatory dysfunction in atherosclerotic coronary artery disease; however, its role in oxidized LDL (Ox-LDL)-induced macrophage foam cell formation and inflammation is unknown and therefore was studied. In
Amit Kumar +5 more
doaj +1 more source
Please Keep Me 2uned to PKM2 [PDF]
Molecular Cell, 2014 In this issue of Molecular Cell, Keller et al. (2014) found that binding of the metabolite SAICAR to PKM2 induces the protein kinase activity of an enzyme normally designed to terminate the glycolytic pathway.
openaire +2 more sources
Structural insight into mechanisms for dynamic regulation of PKM2 [PDF]
Protein & Cell, 2015 Pyruvate kinase isoform M2 (PKM2) converts phosphoenolpyruvate (PEP) to pyruvate and plays an important role in cancer metabolism. Here, we show that post-translational modifications and a patient-derived mutation regulate pyruvate kinase activity of PKM2 through modulating the conformation of the PKM2 tetramer.
Wang, Ping +3 more
openaire +2 more sources