Results 31 to 40 of about 18,059 (264)

Effects of Pyruvate Kinase M2 (PKM2) Gene Deletion on Astrocyte-Specific Glycolysis and Global Cerebral Ischemia-Induced Neuronal Death

Antioxidants, 2023
Ischemic stroke is caused by insufficient blood flow to the brain. Astrocytes have a role in bidirectionally converting pyruvate, generated via glycolysis, into lactate and then supplying it to neurons through astrocyte–neuron lactate shuttle (ANLS ...
B. Kang, B. Choi, A. Kho, S. Lee, D. Hong, M. Park, S. Lee, C. Lee, Hyeun-Wook Yang, S. Woo, Se-Wan Park, Dong-Yeon Kim, J. Park, Won-Suk Chung, S. Suh   +14 more
semanticscholar   +1 more source

Oral Squamous Cell Carcinoma Cells with Acquired Resistance to Erlotinib Are Sensitive to Anti-Cancer Effect of Quercetin via Pyruvate Kinase M2 (PKM2)

Cells, 2023
Oral squamous cell carcinoma (OSCC) frequently carries high epidermal growth factor receptor (EGFR) expression. Erlotinib, a small molecule tyrosine kinase inhibitor (TKI), is an effective inhibitor of EGFR activity; however, resistance to this drug can ...
Chien-Yi Chan, S-C Hong, Chi-Ming Chang, Yuan-Hong Chen, Pin-Chen Liao, Chun-Yin Huang   +5 more
semanticscholar   +1 more source

PKM2 and cancer: The function of PKM2 beyond glycolysis

Oncology Letters, 2016
Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth.
Lin Xu, Gaochao Dong, Jie Wang, Wenjie Xia, Qixing Mao, Feng Jiang, Youtao Xu   +6 more
openaire   +4 more sources

SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury

Innate Immunity, 2023
M1/M2 macrophage polarization plays a pivotal role in the development of acute lung injury (ALI). The hypoxia-inducible factor-1α/pyruvate kinase M2 (HIF-1α/PKM2) axis, which functions upstream of macrophage polarization, has been implicated in this ...
Shuangjun He, Chenyu Fan, Yiming Ji, Qi Su, Feng Zhao, Cui-Hong Xie, Xuelian Chen, Yang Zhang, Yi Chen   +8 more
semanticscholar   +1 more source

Microglia PKM2 Mediates Neuroinflammation and Neuron Loss in Mice Epilepsy through the Astrocyte C3-Neuron C3R Signaling Pathway

Brain Science, 2023
Epilepsy is a neurological disease and approximately 30% of patients have failed to respond to current anti-epilepsy drugs. The neuroinflammation mechanism has raised increasing concerns and been regarded as the novel treatment strategy in epilepsy, but ...
Xinlin Li, Rong Zhou, Hui Peng, Jing Peng, Qiaoling Li, Meng Mei   +5 more
semanticscholar   +1 more source

Correction to: PKM2, function and expression and regulation [PDF]

Cell & Bioscience, 2019
[This corrects the article DOI: 10.1186/s13578-019-0317-8.].
Ze Zhang, Xinyue Deng, Yuanda Liu, Yahui Liu, Liankun Sun, Fangfang Chen   +5 more
openaire   +4 more sources

PKM2 Modulation in Head and Neck Squamous Cell Carcinoma [PDF]

International Journal of Molecular Sciences, 2022
The enzyme pyruvate kinase M2 (PKM2) plays a major role in the switch of tumor cells from oxidative phosphorylation to aerobic glycolysis, one of the hallmarks of cancer. Different allosteric inhibitors or activators and several posttranslational modifications regulate its activity. Head and neck squamous cell carcinoma (HNSCC) is a common disease with
Verena Boschert, Jonas Teusch, Urs D. A. Müller-Richter, Roman C. Brands, Stefan Hartmann   +4 more
openaire   +3 more sources

MiR-1286 inhibits lung cancer growth through aerobic glycolysis by targeting PKM2

Archives of Medical Science, 2019
Introduction This study aims to explore the effects of microRNA-1286 (miR-1286) on the development of non-small cell lung cancer (NSCLC) via the aerobic glycolysis pathway by targeting pyruvate kinase muscle isozyme M2 (PKM2).
Hui Li, Xuexia Lin, Chaopeng Li, Jungai Li, Xunxun Xu, Dongyue Meng, Shushen Zheng   +6 more
doaj   +1 more source

FSTL1 promotes liver fibrosis by reprogramming macrophage function through modulating the intracellular function of PKM2

Gut, 2022
Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented.
J. Rao, Hao Wang, Ming Ni, Zeng Wang, Ziyi Wang, Song Wei, Mu Liu, Peng Wang, Jiannan Qiu, Lei Zhang, Chen Wu, Hongbing Shen, Xuehao Wang, F. Cheng, Ling Lu   +14 more
semanticscholar   +1 more source

PKM2 in carcinogenesis and oncotherapy

Oncotarget, 2017
Tumor cell metabolism is characterized by abundant glucose consumption and aerobic glycolysis. And pyruvate kinase M2 (PKM2) plays a decisive role in glycolysis, significantly contributing to the Warburg effect, tumor growth, angiogenesis, cell division, metastasis and apoptosis.
Yilong Liu, Rongsheng Tong, Xiang Li, Suya Du, Hailian Wang, Yi Wang, Xia He, Tiantian Lei   +7 more
openaire   +2 more sources