Results 31 to 40 of about 9,314 (134)
Please Keep Me 2uned to PKM2 [PDF]
Molecular Cell, 2014 In this issue of Molecular Cell, Keller et al. (2014) found that binding of the metabolite SAICAR to PKM2 induces the protein kinase activity of an enzyme normally designed to terminate the glycolytic pathway.
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JAK-STAT, 2012 The M2 isoform of pyruvate kinase, highly expressed in tumor cells, is known to engage a feed forward loop with the glycolysis master transcription factor HIF-1α. Gao and co-authors recently showed that dimeric PKM2 localizes to the nucleus in highly proliferating cancer cells, where it regulates in vivo growth by acting as a protein kinase and ...
DEMARIA, MARCO, POLI, Valeria
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Research progress on the role of PKM2 in the immune response
Frontiers in Immunology, 2022 Pyruvate kinase (PK) is a key enzyme that catalyzes the dephosphorylation of phosphoenolpyruvate (PEP) into pyruvate, and is responsible for the production of ATP during glycolysis. As another important isozyme of PK, pyruvate kinase M2 (PKM2) exists in cells with high levels of nucleic acid synthesis, such as normal proliferating cells (e.g ...
Chunyan Liu, Chenchen Liu, Rong Fu
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PKM2 Is a Potential Diagnostic and Therapeutic Target for Retinitis Pigmentosa [PDF]
Disease Markers, 2021 Retinitis pigmentosa (RP) is a major cause of blindness that is difficult to diagnose and treat. PKM2, a subtype of pyruvate kinase, is strongly associated with oxidative stress and is expressed in photoreceptors. We investigated whether PKM2 reduces photoreceptor cell apoptosis and evaluated possible antiapoptotic mechanisms in RP.
Peiwen Zhu +3 more
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Science-Business eXchange, 2013 Novartis has shown that the absence of pyruvate kinase M2 isozyme has no effect on cancer cell proliferation in mice, thus suggesting PKM2 inhibition alone might not be an effective strategy to stop tumor growth. Biotechs working on PKM2 modulators think it is too early to write off the target.
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MTR4 drives liver tumorigenesis by promoting cancer metabolic switch through alternative splicing. [PDF]
, 2020 The metabolic switch from oxidative phosphorylation to glycolysis is required for tumorigenesis in order to provide cancer cells with energy and substrates of biosynthesis.
Chen, Wancheng +16 more
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Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]
, 2016 Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K. +2 more
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Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction [PDF]
, 2017 Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from ...
Amenta, Peter S +25 more
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PKM2, a Central Point of Regulation in Cancer Metabolism [PDF]
International Journal of Cell Biology, 2013 Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the demands of proliferation.
Nicholas Wong, Jason De Melo, Damu Tang
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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis [PDF]
, 2011 Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer.
Davidson, Shawn Michael +11 more
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