Results 51 to 60 of about 23,565 (226)

Amifostine enhances the resistance of renal proximal tubular epithelial cells to cisplatin by upregulating PKM2

陆军军医大学学报, 2023
Objective To explore the molecular mechanism of amifostine in relieving cisplatin nephrotoxicity. Methods CCK-8 assay was used to detect the inhibitory effect of amifostine on cisplatin cytotoxicity in HK-2 and primary renal proximal tubular epithelial ...
XUE Rong, MA Jingang, LI Yingping, ZHANG Jian, GAO Peijuan   +4 more
doaj   +1 more source

Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila [PDF]

, 2019
Chromatin organization influences most aspects of gene expression regulation. The linker histone H1, along with the core histones, is a key component of eukaryotic chromatin.
Pearlman, Ronald E., Nabeel-Shah, Syed, Kanwal, Ashraf, Saettone, Alejandro, Garg, Jyoti, Derynck, Joanna, Lambert, Jean-Philippe, Fillingham, Jeffrey   +7 more
core   +1 more source

Long non-coding RNA SRA1 suppresses radiotherapy resistance in esophageal squamous cell carcinoma by modulating glycolytic reprogramming

Open Medicine
Esophageal squamous cell carcinoma (ESCC), a highly aggressive subtype of esophageal cancer, is characterized by late-stage diagnosis and limited treatment options.
Chen Yurao, Fan Peng, Chen Zhenhai, Zheng Zemao, He Ming, Zhao Xiang, Chen Ronghuai, Yao Juan, Yang Zhaodong   +8 more
doaj   +1 more source

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction [PDF]

, 2017
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are limited. To identify novel therapeutic strategies, we studied protective factors for DN using proteomics on glomeruli from ...
Amenta, Peter S, Burkart, Alison M, Cahill, Christopher, Coppey, Lawrence J, Feener, Edward P, Hastings, Stephanie, Ishikado, Atsushi, Israelsen, William J, Kannt, Aimo, Keenan, Hillary A, King, George L, Li, Qian, Liew, Chong Wee, Lockhart, Samuel, Niewczas, Monika A, Pfenninger, Anja, Pober, David, Qi, Weier, Qiang, Guifen, Sadowski, Thorsten, Stanton, Robert C, Stillman, Isaac E, Tinsley, Liane, Vander Heiden, Matthew G., Wu, I-Hsien, Yorek, Mark A   +25 more
core   +1 more source

Cell Cycle Control of Nuclear Metabolism Couples Phosphatidylinositol Signaling to Histone Methylation

Advanced Science, EarlyView.
Nuclear metabolism oscillates during cell cycle progression. Quantitative chromatome proteomics and imaging reveal phase‐specific dynamics of PIP5K1A and nuclear PIP2, linking phosphatidylinositol metabolism to histone methylation. This work identifies nuclear lipid metabolism as a previously unrecognized regulatory axis coordinating chromatin ...
Antoni Gañez‐Zapater, Savvas Kourtis, Camilla Reiter Elbæk, Lorena Espinar, Carolina Toro‐Márquez, Albert Coll‐Manzano, Alfredo Smiriglia, Laura García‐López, Laura Wiegand, Maria Guirola, Frédéric Fontaine, Andrea Morandi, André C. Müller, Sara Sdelci   +13 more
wiley   +1 more source

PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition

Analytical Cellular Pathology, 2020
Breast cancer is the leading cause of females characterized by high invasive potential. It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets. PKM2 is considered a new biomarker of cancer
Hui Xiao, Longxiao Zhang, Yuan Chen, Chengjun Zhou, Xiao Wang, Dehai Wang, Zhenzhong Liu   +6 more
doaj   +1 more source

PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas

Frontiers in Oncology, 2022
PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba, Shigeo Ohba, Yongjian Tang, Yongjian Tang, Tor-Christian Aase Johannessen, Tor-Christian Aase Johannessen, Joydeep Mukherjee   +6 more
doaj   +1 more source

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis [PDF]

, 2011
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered glucose metabolism in cancer.
Davidson, Shawn Michael, Fiske, Brian Prescott, Israelsen, William James, Jha, Abhishek K., Johnson, Zachary, Khan, Tahsin M., Lunt, Sophia Yunkyungkwon, Malstrom, Scott E., Mattaini, Katherine Ruth, Stephano, Gregory, Vander Heiden, Matthew G., Yu, Yimin   +11 more
core   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

PTDSS1 Drives Glycolysis and Malignant Progression of Lung Cancer Through Maintaining Nuclear–Mitochondrial Homeostatic Crosstalk

Frontiers in Bioscience-Landmark
Background: Phosphatidylserine synthase 1 (PTDSS1) is a crucial enzyme involved in phospholipid synthesis. However, its role in the metabolic regulation of lung cancer remains unclear.
Hailun Wang, Qiao Wang, Yandu He, Xuelu Pu, Yajun Li   +4 more
doaj   +1 more source