Results 61 to 70 of about 23,565 (226)
Scientific Reports, 2018 Warburg effect is an emerging hallmark of cancer cells with pyruvate kinase M2 (PKM2) as its key regulator. Curcumin is an extensively-studied anti-cancer compound, however, its role in affecting cancer metabolism remains poorly understood.
Farid Ahmad Siddiqui +11 more
doaj +1 more source
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Nuclear translocation of pyruvate kinase M2 drives high glucose-induced angiogenesis in retinal endothelial cells via the HIF-1α axis [PDF]
International Journal of OphthalmologyAIM: To investigate the role of pyruvate kinase M2 (PKM2) in high glucose (HG)-stimulated retinal endothelial cells and its underlying molecular mechanisms and signaling pathways in retinal angiogenesis.
Tian-Yi Liu +8 more
doaj +1 more source
Frontiers in Immunology, 2021 Toll-like receptors (TLRs) play critical roles in regulating the abnormal activation of the immune cells resulting in the pathogenesis of inflammation and autoimmune diseases.
Xin Zhang +22 more
doaj +1 more source
Hypoxia Signaling Pathway in Stem Cell Regulation: Good and Evil [PDF]
, 2018 Purpose of Review: This review summarizes the role of hypoxia and hypoxia-inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on maintenance, differentiation, and stress responses in the context of several stem cell ...
Aljoufi, Arafat +3 more
core +1 more source
A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects
Advanced Science, EarlyView.Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi +12 more
wiley +1 more source
PKM2 regulates Gli1 expression in hepatocellular carcinoma
Oncology Letters, 2014 Hedgehog (Hh) signaling and the pyruvate kinase isoenzyme M2 (PKM2 or M2-PK) are often involved in tumorigenesis and growth. Aberrant activation of Hh signaling is found in a variety of malignancies. In tumor cells, PKM2 determines whether glucose is used for the synthesis of cellular building blocks or the production of lactate for energy regeneration;
XU, QIURAN +4 more
openaire +3 more sources
PKM2 (pyruvate kinase isoenzyme type M2) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on PKM2 (pyruvate kinase isoenzyme type M2), with data on DNA, on the protein encoded, and where the gene is implicated.
Mazurek, S, Hugo, F, Zwerschke, W
openaire +2 more sources
Advanced Science, EarlyView.A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang +9 more
wiley +1 more source
Podocyte specific deletion of PKM2 ameliorates LPS-induced podocyte injury through beta-catenin
Cell Communication and Signaling, 2022 Background Acute kidney injury (AKI) is associated with a severe decline in kidney function caused by abnormalities within the podocytes' glomerular matrix. Recently, AKI has been linked to alterations in glycolysis and the activity of glycolytic enzymes,
Mohammed Alquraishi +13 more
doaj +1 more source