Results 81 to 90 of about 23,565 (226)

SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice

Cell Reports, 2017
LPS-activated macrophages undergo a metabolic shift from dependence on mitochondria-produced ATP to reliance on aerobic glycolysis, where PKM2 is a critical determinant.
Fang Wang, Ke Wang, Wei Xu, Shimin Zhao, Dan Ye, Yi Wang, Ying Xu, Lisha Zhou, Yiwei Chu, Cuiping Zhang, Xue Qin, Pengyuan Yang, Hongxiu Yu   +12 more
doaj   +1 more source

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation [PDF]

, 2017
Aerobic glycolysis supports proliferation through unresolved mechanisms. We have previously shown that aerobic glycolysis is required for the regulated proliferation of cerebellar granule neuron progenitors (CGNP) and for the growth of CGNP-derived ...
Farooq, Hamza, Fish, Taylor, Gershon, Timothy R., Green, Sarah C., Jones, Steven J.M., Li, Yisu, Liu, Hedi, Ma, Yussanne, Macdonald, Jeffrey M., Marra, Marco A., Meidinger, Jessica, Moore, Richard A., Morrissy, A. Sorana, Mungall, Andrew J., Taylor, Michael D., Tech, Katherine, Tikunov, Andrey P., Vander Heiden, Matthew G.   +17 more
core   +1 more source

Focused Ultrasound‐Induced Mechanical Ablation Affects the Carbohydrate Metabolism of Residual/Peri‐Focally Localized Glioblastoma Cells

International Journal of Cancer, EarlyView.
Glioblastoma (GBM) is highly aggressive and therapy‐resistant, warranting exploration of novel treatment strategies, among them mechanical high‐intensity focused ultrasound (mFUS), which holds significant promise for tumor ablation. The present study examined mFUS‐induced changes specifically in carbohydrate metabolism, which affects vulnerability to ...
Frieda Bayler, Jonna Holler, Jacqueline Clüver, Levi Johanning, Dana Hellmold, Nils Oliver Schröder, Jessica Nojszewski, Hajrullah Ahmeti, Carolin Kubelt‐Kwamin, Michael Synowitz, Janka Held‐Feindt   +10 more
wiley   +1 more source

Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

BMC Cancer, 2018
Background Hepatocellular carcinoma (HCC) is a malignant tumor that threatens global human health. High PKM2 expression is widely reported in multiple cancers, especially in HCC.
Wen-Wen Lv, Dahai Liu, Xing-Cun Liu, Tie-Nan Feng, Lei Li, Bi-Yun Qian, Wen-Xing Li   +6 more
doaj   +1 more source

Lactate secreted by PKM2 upregulation promotes Galectin-9-mediated immunosuppression via inhibiting NF-κB pathway in HNSCC

Cell Death and Disease, 2021
Pyruvate kinase M2 as a key rate-limiting enzyme in glycolysis, it plays a critical role in metabolic reprogramming and carcinogenesis. However, whether PKM2 can promote immunosuppressive microenvironment formation remains unknown in head and neck ...
Hanyue Chang, Qiaoshi Xu, Jiayi Li, Mingyu Li, Zhiyuan Zhang, Hailong Ma, Xi Yang   +6 more
doaj   +1 more source

One-carbon metabolism in cancer [PDF]

, 2017
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells.
AJ MacFarlane, Alice C Newman, AS Tibbetts, B Chaneton, BC Blount, C Commisso, CA Lewis, CF Labuschagne, CF Woeller, D Hanahan, D Hanahan, D Kim, DD Anderson, E Currie, E Mullarky, F Daidone, F Kottakis, G Kikuchi, GM DeNicola, Gregory S. Ducker, GS Ducker, J Liu, J Meiser, J Ye, Jason W. Locasale, JJ Kamphorst, JW Locasale, K Snell, K Snell, K Snell, Katherine R. Mattaini, L Galluzzi, M Goulian, M Jain, M Kulis, Mahya Mehrmohamadi, ME Pacold, Ming Yang, MJ Osborn, ML Rose, ML Rose, OD Maddocks, OD Maddocks, Oliver D K Maddocks, Oliver D. K. Maddocks, PM Ueland, R Possemato, S Farber, S Kit, S Pollari, SJ Mentch, Swetha Bolusani, T Shlomi, WC Zhang, Y Fu, Z Ser   +55 more
core   +1 more source

Lack of Evidence for PKM2 Protein Kinase Activity [PDF]

Molecular Cell, 2015
The role of pyruvate kinase M2 (PKM2) in cell proliferation is controversial. A unique function of PKM2 proposed to be important for the proliferation of some cancer cells involves the direct activity of this enzyme as a protein kinase; however, a detailed biochemical characterization of this activity is lacking. Using [(32)P]-phosphoenolpyruvate (PEP)
Hosios, Aaron Marc, Fiske, Brian Prescott, Gui, Dan Yi, Vander Heiden, Matthew G.   +3 more
openaire   +4 more sources

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart

Physiological Reports
Inflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM).
Katie C. Y. Lee, Allison L. Williams, Akitoshi Hara, Vedbar S. Khadka, Jeffrey Hayashi, Ralph V. Shohet   +5 more
doaj   +1 more source

Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression [PDF]

, 2011
Online supplemental material is available at http://www.jem.org/cgi/content/full/jem.20111487/DC1.The development of cancer-specific therapeutics has been limited because most healthy cells and cancer cells depend on common pathways. Pyruvate kinase (PK)
Akinc, Ashizawa, Bonnet, Boxer, Christofk, Christofk, Clower, David, DeBerardinis, Dombrauckas, Ferguson, Goldberg, Guo, Hornung, Huang, Jackson, Jurica, Kleinman, Lee, Love, Mazurek, Michael S. Goldberg, Michelakis, Noguchi, Phillip A. Sharp, Semenza, Shi, Ugurel, Vander Heiden, Vander Heiden, Vander Heiden, Wang, Wang, Warburg   +33 more
core   +1 more source