Results 41 to 50 of about 14,270 (217)
Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
Molecular & Cellular Oncology, 2018 Isoform selection of pyruvate kinase M (PKM), a glycolytic enzyme, influences fates of glucose-derived carbons in cellular metabolic networks. We recently developed novel mouse lines to study PKM isoform function and identified PKM1 as a potential target
Taku Sato +3 more
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PKM2 functions as a histone kinase [PDF]
Cell Cycle, 2012 In the presence of oxygen, most differentiated cells generate the energy needed for cellular processes primarily by metabolizing glucose to carbon dioxide by oxidation of glycolytic pyruvate in the mitochondrial tricarboxylic acid cycle. When oxygen becomes limited, differentiated cells produce large amounts of lactate.
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Cancer & Metabolism, 2018 Background Alternative splicing of the Pkm gene product generates the PKM1 and PKM2 isoforms of the glycolytic enzyme pyruvate kinase. PKM2 expression is associated with embryogenesis, tissue regeneration, and cancer.
Talya L. Dayton +7 more
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FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis [PDF]
Molecular Oncology, 2020 Tumor growth, especially in the late stage, requires adequate nutrients and rich vasculature, in which PKM2 plays a convergent role. It has been reported that PKM2, together with FOXM1D, is upregulated in late‐stage colorectal cancer and associated with metastasis; however, their underlying mechanism for promoting tumor progression remains elusive ...
Wei Zhang +15 more
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JAK-STAT, 2012 The M2 isoform of pyruvate kinase, highly expressed in tumor cells, is known to engage a feed forward loop with the glycolysis master transcription factor HIF-1α. Gao and co-authors recently showed that dimeric PKM2 localizes to the nucleus in highly proliferating cancer cells, where it regulates in vivo growth by acting as a protein kinase and ...
DEMARIA, MARCO, POLI, Valeria
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Frontiers in Pharmacology, 2021 Psoriasis is characterized by keratinocyte proliferation and immune cell infiltration. M2 isoform of pyruvate kinase (PKM2) was reported to have an important role in cell proliferation, which is a rate-limiting enzyme that regulates the final step of ...
Yun-zi Liu +16 more
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Research progress on the role of PKM2 in the immune response
Frontiers in Immunology, 2022 Pyruvate kinase (PK) is a key enzyme that catalyzes the dephosphorylation of phosphoenolpyruvate (PEP) into pyruvate, and is responsible for the production of ATP during glycolysis. As another important isozyme of PK, pyruvate kinase M2 (PKM2) exists in cells with high levels of nucleic acid synthesis, such as normal proliferating cells (e.g ...
Chunyan Liu, Chenchen Liu, Rong Fu
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PKM2 is not required for colon cancer initiated by APC loss
Cancer & Metabolism, 2017 Background Cancer cells express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2). PKM2 expression is not required for some cancers, and PKM2 loss can promote cancer progression; however, PKM2 has been reported to be essential in other tumor
Allison N. Lau +10 more
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Please Keep Me 2uned to PKM2 [PDF]
Molecular Cell, 2014 In this issue of Molecular Cell, Keller et al. (2014) found that binding of the metabolite SAICAR to PKM2 induces the protein kinase activity of an enzyme normally designed to terminate the glycolytic pathway.
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Structural insight into mechanisms for dynamic regulation of PKM2 [PDF]
Protein & Cell, 2015 Pyruvate kinase isoform M2 (PKM2) converts phosphoenolpyruvate (PEP) to pyruvate and plays an important role in cancer metabolism. Here, we show that post-translational modifications and a patient-derived mutation regulate pyruvate kinase activity of PKM2 through modulating the conformation of the PKM2 tetramer.
Yanhui Xu +4 more
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