Results 41 to 50 of about 16,547 (202)
Molecular Cancer, 2017 Background Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and metastasis of cancer cells, has ...
Qiuran Xu +12 more
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F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway
Advanced Science, EarlyView.In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu +16 more
wiley +1 more source
Pyruvate kinase M2 is a poor prognostic marker of and a therapeutic target in ovarian cancer. [PDF]
PLoS ONE, 2017 Pyruvate kinase M2 (PKM2) regulates glycolysis and oxidative phosphorylation; however, the role of PKM2 in ovarian cancer remains largely unknown. We investigated whether ovarian cancer metabolism could provide insight into the development of therapeutic
Tai-Kuang Chao +7 more
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Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy
BMEMat, EarlyView.This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma +9 more
wiley +1 more source
Loss of PKM2 dysregulates inflammatory signaling in the infarcted murine heart
Physiological ReportsInflammation and a metabolic shift from oxidative metabolism to glycolysis are common in the ischemic heart, the latter partly controlled by pyruvate kinase (muscle, PKM).
Katie C. Y. Lee +5 more
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A novel miR-490-3p/hnRNPA1-b/PKM2 axis intermediates the Warburg effect and proliferation of colon cancer via PI3K/AKT pathway [PDF]
, 2023 Xianghui Wan +10 more
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Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
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Nature CommunicationsMost cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation to aerobic glycolysis for energy production. By reducing enzyme activity of pyruvate kinase M2 (PKM2), cancer cells attain a greater fraction of glycolytic ...
Rong-Hsuan Wang +20 more
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Knockdown of PKM2 enhances radiosensitivity of cervical cancer cells
Cancer Cell International, 2019 Background Pyruvate kinase isozyme type M2 (PKM2) catalyzes the final step in glycolysis and has been found to be up-regulated in multiple human malignancies.
Yanzhu Lin +6 more
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Vitexin, an apigenin flavone glycoside, exhibits antitumor activity against various cancers including leukemia. Hypoxia enhances glycolysis, thereby promoting tumor growth. In this study, we aimed to explore the effects of vitexin on hypoxia‐induced growth and glycolysis in acute myeloid leukemia (AML) cells and determine the underlying ...
Ping Wang +4 more
wiley +1 more source