Results 41 to 50 of about 154,900 (257)
On the Cutting Edge: Border Integration and Security in Europe and North America [PDF]
Within the rich literature on regional integration and immigration, many scholars discuss border issues. Nonetheless, rarely are border areas comparatively examined, despite the fact that they are most exposed to these international phenomena. This paper
Harlan Koff
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Security of Payment in the Construction Industry: Does International Experience Provide a Crystal Ball for North America? [PDF]
, 2018 Over the past two decades, more than a dozen jurisdictions around the world have enacted legislative reform programs to promote ‘security of payment’ within their construction industries. There are two linked foundations to these reforms: ensuring prompt
Ennis, C +5 more
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, 2023 Winter cold extreme events have been observed to frequently take place over North America mainly over its east side, which show significant interannual and decadal variability and cause huge economic losses in the United States.
Dehai Luo, Yao Ge
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Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2016 The Neo-Latin poetry and prose from North America have already been well surveyed. Drawing on recent historical work, I propose instead to study the place of Neo-Latin writing in the broader history of attitudes toward Latin and the classics in North ...
Blair, Ann
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 1880 Map shows geography and place names in late nineteenth century North America. Includes sketches of American wildlife, mining industries, natural landscapes, and natural resources by Albert Richter. Relief shown by shading and spot heights.
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