Results 61 to 70 of about 2,514,874 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Late cretaceous extensional tectonics and associated igneous activity on the northern margin of the Gulf of Mexico Basin [PDF]

Major, dominantly compressional, orogenic episodes (Taconic, Acadian, Alleghenian) affected eastern North America during the Paleozoic. During the Mesozoic, in contrast, this same region was principally affected by epeirogenic and extensional tectonism ...
Bowen, R. L., Sundeen, D. A.
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Contextualized Metrics + Narrating Binaries: Defining Place and Processing Indigenous North America

Cross Americas: Probing Disglobal Networks- Papers, 2016
This paper introduces four cultural catalysts in Indigenous architecture: language, place, kinship and transformation. Inspired by the interrelationship of physical, sociocultural and spiritual factors- the measurable and immeasurable – we investigate a number of concepts related to Indigenous thinking and ways of knowing.
openaire   +1 more source

Effects of place attachment on home return travel: a spatial perspective [PDF]

, 2016
Recent studies on place-mobility relationships suggest an increasing possibility that people can have multiple place attachments at varied spatial scales.
Basu P., Basu P., Bertaux D., Bob McKercher, Cohen R., Coles T., Con H., Dwyer L., Fried M., Geipel R., Government of Canada, Guangdong OCAO, Hollinshead K., Jiangmen Government, Kemp C., Levitt P., Lew A., Li P. S., Marcus G. E., Massey D., Massey D., Mei W., Michelson W., Morse J., Nguye T. H., Pan L., Relph E., Shenton A. K., Skeldon R., Tajfel H., Tingting Elle Li, Van den Berghe P. L., Zhao H.   +32 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Biodistance Analysis of North and South American Populations [PDF]

, 2018
This project was awarded third place in "History of People and Art" at the 2018 Richard J. And Martha D. Denman Undergraduate Research ForumArchaeological evidence suggests that humans were already present in both North and South America by 12.5-11.5 ...
Stamer, Julianne
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

La Situació de l'economia mundial : hem superat la crisi? [PDF]

, 2001
Financial markets all over the world suffer from instability and turbulence unknown in decades. Starting in South East Asia, the peak was reached with the Russian debt moratorium.
Joaquim Ferran
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source