Results 71 to 80 of about 4,146,309 (298)

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Festival place or place of festival? The role of place identity and attachment in the festival environment [PDF]

, 2014
This paper addresses place identity and attachment theory in the context of events. Viewing place as a symbolic part of the consumption process, a "Model of Festival Place" is developed.
Davis, Andrew, Martin, Andrew
core   +3 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Proenvironmental behavior: Critical link between satisfaction and place attachment in Australia and Canada [PDF]

, 2017
This study explores issues of scale equivalence and generalizability in national parks. Visitors' place satisfaction, proenvironmental behavior, and place attachment are measured across two qualitatively distinct populations in Australia and Canada ...
Mavondo, F. T., Ramkissoon, H., Mavondo, F., Mavondo, F.T., Ramkissoon, H, Felix T. Mavondo, Haywantee Ramkissoon, Ramkissoon, Haywantee   +7 more
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The Relationship of Place Attachment and Subjective Wellbeing: Heritage City Johor Bahru

International Journal of Built Environment and Sustainability
Heritage cities encompass a wide array of tangible and intangible cultural resources, including historical structures, architectural styles, customs, and cultural environments.
Shahida Nur Nabila Samsur, Nafisa Hosni, Khairul Hisyam Kamarudin   +2 more
doaj   +1 more source

Place attachment in a foreign settlement [PDF]

Journal of Environmental Psychology, 2009
This paper examines issues arising from the involuntary relocation of Turkish Cypriot refugees from the southern to the northern portion of the island of Cyprus. After the ceasefire in 1974, participants in this study were relocated into homes originally built and occupied by Greek Cypriots.
openaire   +3 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Importance of attachment to place in growing a sustainable Australian Rural Health Workforce: A rapid review

, 2021
Introduction: Personal, community, and environmental factors can influence the attraction and retention of regional, rural, and remote health workers.
Rowena McGregor, Kelly, Tricia, Rana, Rezwanul, Tricia Kelly, Lisa Beccaria, McGregor, Rowena, McIlveen, Peter, Erich C. Fein, Beccaria, Lisa, Fein, Erich C., Peter McIlveen, Rana Rezwanul   +11 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source