Results 91 to 100 of about 4,146,309 (298)

Place attachment assessment of a heritage place: A case study of the Roman amphitheater in downtown Amman, Jordan

open access: yesFrontiers of Architectural Research, 2018
This research investigated the place attachment of a heritage place, namely, the Roman amphitheater, by using a valid model, the Kyle, Graefe, and Manning (2005) model.
Jawdat S. Goussous, Nessma A. Al-Hammadi
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

The influence of urban parkettes on landscape values and place attachment in Kigali city, Rwanda

open access: yesJournal of Asian Architecture and Building Engineering
Urban parkettes as green spaces are vital for several landscape values. They are realms for place attachments (PA) through place dependence (PD) and place identity (PI). Growing concern is on dwindling green spaces due to rapid urbanization. Studies that
Edwin Oluoch K’oyoo
doaj   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

open access: yesFEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

open access: yesFEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo   +6 more
wiley   +1 more source

Language brokering experience, attachment style, role reversal, parentification, self-efficacy and wellbeing : a retrospective study

open access: yes, 2013
This study explored positive and negative experiences of language brokers (16-62 years; M=25.02, SD=9.21) in an Australian sample (N=99; 76 females and 23 males). Further, it also explored the relationship between language brokering with attachment style,
Narchal, Renu (R10093)
core  

The role of place attachment in tourism research

open access: yes, 2019
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Place attachment has become an important concept in tourism-related research, with substantial relevance for the nature of the human-place relationship and behavioural intentions and ...
Chen, Ning Chris   +5 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

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