Results 91 to 100 of about 941,534 (305)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Sense of Place Among Adolescents: Factors Influencing the Place Attachment on Shopping Malls [PDF]
, 2015 This research aims to find the push factors that create relationships between youth and shopping centers and examines how different mall environments also help create different emotional bonds towards the malls.
Kusumowidagdo, A. (Astrid) +2 more
core +2 more sources
Public Attachment to Religious Places: A Study of Place Attachment to Mosques in Malaysia
, 2013 {"references": ["Altman, I. and S.M. Low, Place attachment. 1992, New York: Plenum Press.", "Giuliani, M.V. and R. Feldman, Place attachment in a developmental and cultural context. Journal of Environmental Psychology, 1993. 13: p. 267-274.", "Manzo, L.C., Beyond house and haven: Toward a revisioning of emotional relationships with places.
Mina Najafi +1 more
openaire +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Place attachment towards waterfront in Kangar, Perlis, Malaysia [PDF]
, 2016 This paper discusses place attachment to Kangar Waterfront in the state of Perlis, Malaysia. A questionnaire survey was conducted with users of the water front to identify the level of attachment, form of engagement and factors that influence the ...
Abdul Aziz, Faziawati +2 more
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Frontiers of Architectural Research, 2018 This research investigated the place attachment of a heritage place, namely, the Roman amphitheater, by using a valid model, the Kyle, Graefe, and Manning (2005) model.
Jawdat S. Goussous, Nessma A. Al-Hammadi
doaj +1 more source
Developing a typology of diaspora tourists: return travel by Chinese immigrants in North America [PDF]
, 2016 This paper examines the role played by tourism in affecting cultural identity and place attachment among members of the North American Chinese diaspora who travel to China.
Li, Tingting Elle, McKercher, Bob
core +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source