Results 141 to 150 of about 9,473,872 (308)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Spatial localization of hippocampal replay requires dopamine signaling

eLife
Sequenced reactivations of hippocampal neurons called replays, concomitant with sharp-wave ripples in the local field potential, are critical for the consolidation of episodic memory, but whether replays depend on the brain’s reward or novelty signals is
Matthew R Kleinman, David J Foster
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Spatial memory: Place cell activity is causally related to behavior. [PDF]

Curr Biol, 2021
Plitt MH, Giocomo LM.
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sensing Place

, 2019
This project aims to explore whether quantitative methods of digital and parametric design can adequately encompass place. Quantitative digital and parametric approaches increasingly dominate contemporary architecture, but people assume architectural ...
Roudavski, S, Julian Rutten, Taylor, M, Stanislav Roudavski, Mark Taylor, Virginia Lee, Rutten, J, Lee, V, Jeff Malpas, Mark Burry, Burry, M, Malpas, J   +11 more
core  

Beyond correlation: optimal transport metrics for characterizing representational stability and remapping in neurons encoding spatial memory

Frontiers in Cellular Neuroscience
IntroductionSpatial representations in the entorhinal cortex (EC) and hippocampus (HPC) are fundamental to cognitive functions like navigation and memory.
Andrew Aoun, Andrew Aoun, Oliver Shetler, Oliver Shetler, Radha Raghuraman, Radha Raghuraman, Gustavo A. Rodriguez, Gustavo A. Rodriguez, S. Abid Hussaini, S. Abid Hussaini   +9 more
doaj   +1 more source

Place-cell capacity and volatility with grid-like inputs. [PDF]

Elife, 2021
Yim MY, Sadun LA, Fiete IR, Taillefumier T.   +3 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Student interview for Place-Based WAC/WID writing instruction in English, clip 1 of 15

, 2015
This item includes a segment of an a student interview in a Writing Intensive course in English at the University of Hawaiʻi at Mānoa. The interview was conducted in 2014 and in this clip the interviewee is discussing writing a homeless poem.Brief ...
Place-based WAC/WID Hui
core