Results 91 to 100 of about 17,689,950 (324)

In vivo Calcium Imaging Reveals That Cortisol Treatment Reduces the Number of Place Cells in Thy1-GCaMP6f Transgenic Mice

Frontiers in Neuroscience, 2019
The hippocampus, a structure essential for spatial navigation and memory undergoes anatomical and functional changes during chronic stress. Here, we investigate the effects of chronic stress on the ability of place cells to encode the neural ...
Tim Indersmitten, Michael J. Schachter, Stephanie Young, Natalie Welty, Stephani Otte, Jonathan J. Nassi, Timothy Lovenberg, Pascal Bonaventure, Ryan M. Wyatt   +8 more
doaj   +1 more source

The Importance of Forgetting: Limiting Memory Improves Recovery of Topological Characteristics from Neural Data

, 2017
We develop of a line of work initiated by Curto and Itskov towards understanding the amount of information contained in the spike trains of hippocampal place cells via topology considerations.
Chowdhury, Samir, Dai, Bowen, Mémoli, Facundo   +2 more
core   +2 more sources

CPX‐351 in High‐Risk Relapsed Pediatric Acute Leukemia: Real‐World Phase 1 Data Establishing the FDA‐Approved Dose

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Outcomes for pediatric relapsed/refractory (R/R) acute myeloid leukemia (AML) remain dismal. CPX‐351, a liposomal formulation of cytarabine and daunorubicin, may have less off‐target toxicities than traditional chemotherapies and has shown improved outcomes for adults with newly diagnosed therapy‐related AML.
Jonathan D. Bender, Lauren Pommert, Lori R. Backus, Andrea Bidwell, Courtney Blank, Erin H. Breese, Karen C. Burns, Adam Lane, Lynn H. Lee, Benjamin Mizukawa, Robin E. Norris, Maureen M. O'Brien, Daniel Peck, Christine Phillips, Thomas D. Ryan, Jennifer Young, Michael Absalon, John P. Perentesis   +17 more
wiley   +1 more source

Differences in firing patterns along the dorsal-intermediate hippocampal axis in a fixed route during a change in emotional context

Frontiers in Systems Neuroscience
The hippocampus plays a prominent role in spatial navigation and memory. However, differences exist along the hippocampus longitudinal axis in function and connectivity.
Ryan Troha, Shang Lin (Tommy) Lee, Maya Anam, Sheela Tavakoli, Bailey Morte, Ian H. Stevenson, Etan J. Markus   +6 more
doaj   +1 more source

Neural Dynamics Indicate Parallel Integration of Environmental and Self-Motion Information by Place and Grid Cells

Frontiers in Neural Circuits, 2019
Place cells and grid cells in the hippocampal formation are thought to integrate sensory and self-motion information into a representation of estimated spatial location, but the precise mechanism is unknown.
Dmitri Laptev, Dmitri Laptev, Neil Burgess   +2 more
doaj   +1 more source

The little brain and the seahorse: Cerebellar-hippocampal interactions

Frontiers in Systems Neuroscience, 2023
There is a growing appreciation for the cerebellum beyond its role in motor function and accumulating evidence that the cerebellum and hippocampus interact across a range of brain states and behaviors.
Jessica M. Froula, Shayne D. Hastings, Esther Krook-Magnuson   +2 more
doaj   +1 more source

In vivo characterization of hippocampal electrophysiological processes in the heterozygous Pten knockout model of autism [PDF]

, 2018
While cognitive deficits have been described in the heterozygous Pten (+/-) KO mouse model of autism, little work has been done to demonstrate how corresponding in vitro physiological alterations in this model may underpin these cognitive deficits in ...
Barry, Jeremy, Spinella, Anthony J, Weston, Matthew   +2 more
core   +1 more source

Incidence and Risk Factors of Serious Osteonecrosis in Pediatric Acute Lymphoblastic Leukemia: A CYP‐C Population‐Based Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers, Chantal Éthier, Caroline Laverdière, Nathalie Alos, Thai Hoa Tran, Marie‐Claude Pelland‐Marcotte   +5 more
wiley   +1 more source

Temporal context and latent state inference in the hippocampal splitter signal

eLife, 2023
The hippocampus is thought to enable the encoding and retrieval of ongoing experience, the organization of that experience into structured representations like contexts, maps, and schemas, and the use of these structures to plan for the future. A central
Éléonore Duvelle, Roddy M Grieves, Matthijs AA van der Meer   +2 more
doaj   +1 more source

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell, Allison Close, Guoli Zhou, Troy C. Quigg   +3 more
wiley   +1 more source