Results 131 to 140 of about 2,280,368 (270)

Enhanced Reactivation of Remapping Place Cells during Aversive Learning. [PDF]

J Neurosci, 2023
Ormond J, Serka SA, Johansen JP.
europepmc   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality

eLife
Contextual fear conditioning (CFC) is a classical laboratory task that tests associative memory formation and recall. Techniques such as multi-photon microscopy and holographic stimulation offer tremendous opportunities to understand the neural ...
Seetha Krishnan, Can Dong, Heather Ratigan, Denisse Morales-Rodriguez, Chery Cherian, Mark Sheffield   +5 more
doaj   +1 more source

Learning Spatiotemporal Properties of Hippocampal Place Cells. [PDF]

eNeuro, 2022
Lian Y, Burkitt AN.
europepmc   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The cerebellum promotes sequential foraging strategies and contributes to the directional modulation of hippocampal place cells. [PDF]

iScience, 2023
Zhang L, Fournier J, Fallahnezhad M, Paradis AL, Rochefort C, Rondi-Reig L.   +5 more
europepmc   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Leveraging place field repetition to understand positional versus nonpositional inputs to hippocampal field CA1

eLife
The hippocampus is believed to encode episodic memory by binding information about the content of experience within a spatiotemporal framework encoding the location and temporal context of that experience.
William Hockeimer, Ruo-Yah Lai, Maanasa Natrajan, William Snider, James J Knierim   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Spatial memory deficits in Alzheimer's disease and their connection to cognitive maps' formation by place cells and grid cells. [PDF]

Front Behav Neurosci, 2022
Silva A, Martínez MC.
europepmc   +1 more source