Results 141 to 150 of about 16,525,519 (328)
Hippocampal Remapping and Its Entorhinal Origin
Frontiers in Behavioral Neuroscience, 2018 The activity of hippocampal cell ensembles is an accurate predictor of the position of an animal in its surrounding space. One key property of hippocampal cell ensembles is their ability to change in response to alterations in the surrounding environment,
Patrick Latuske +3 more
doaj +1 more source
The Discovery of the Hippocampal Place Cells
HippocampusABSTRACT This paper describes the events leading up to the discovery of the place cells in 1971 for which the author received the Nobel Prize in Physiology and Medicine in 2014, together with May‐Britt and Edvard Moser. In addition, it explores some of the ideas and influences that contributed to the interpretation of that finding as ...
openaire +2 more sources
Grid Cells and Place Cells: An Integrated View of their Navigational and Memory Function
Trends in Neurosciences, 2015 Much has been learned about the hippocampal/entorhinal system, but an overview of how its parts work in an integrated way is lacking. One question regards the function of entorhinal grid cells.
Honi Sanders +3 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Lateral entorhinal cortex is necessary for associative but not nonassociative recognition memory
, 2013 This work was supported by BBSRC [Grant number BB/I019367/1]The lateral entorhinal cortex (LEC) provides one of the two major input pathways to the hippocampus and has been suggested to process the nonspatial contextual details of episodic memory ...
Milner, Helen Louise +3 more
core +1 more source
Slow and fast gamma rhythms coordinate different spatial coding modes in hippocampal place cells
Neuron, 2014 SUMMARY Previous work has hinted that prospective and retrospective coding modes exist in hippocampus. Prospective coding is believed to reflect memory retrieval processes, whereas retrospective coding is thought to be important for memory encoding. Here,
K. Bieri, Katelyn N. Bobbitt, L. Colgin
semanticscholar +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
, 2011 Previously we reported that the hippocampus place code must be an ensemble code because place cells in the CA1 region of hippocampus have multiple place fields in a more natural, larger-than-standard enclosure with stairs that permitted movements in 3-D.
André A. Fenton +6 more
core +1 more source