Results 131 to 140 of about 16,525,519 (328)
Putting fear in its place: remapping of hippocampal place cells during fear conditioning [PDF]
, 2004 We recorded hippocampal place cells in two spatial environments: a training environment in which rats underwent fear conditioning and a neutral control environment.
LeDoux, JE +4 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
An Intranet of Things approach for adaptable control of behavioral and navigation-based experiments
eLifeInvestigators conducting behavioral experiments often need precise control over the timing of the delivery of stimuli to subjects and to collect precise times of subsequent behavioral responses. Furthermore, investigators want fine-tuned control over how
John C Bowler +7 more
doaj +1 more source
Short‐term plasticity based network model of place cells dynamics
Hippocampus, 2015 Rodent hippocampus exhibits strikingly different regimes of population activity in different behavioral states. During locomotion, hippocampal activity oscillates at theta frequency (5–12 Hz) and cells fire at specific locations in the environment, the ...
S. Romani, M. Tsodyks
semanticscholar +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Stem cells from oocytes and oocytes from stem cells
, 2011 : Full oocyte competence is the indispensable requisite for embryonic development and, at present, no ways are known to restore competence if, for any reason, it has been even slightly compromised.
A. Vanelli +4 more
core +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Reprogramming of mesenchymal stem cells and adult fibroblasts following nuclear transfer in rabbits [PDF]
, 2009 The main aim of this thesis was to find out which donor cells would be most suitable for production of cloned rabbits with a targeted modification of their genome, and their corresponding patterns of reprogramming hetero- and euchromatic histone ...
Hao, Ru
core
Alterations of hippocampal place cells in foraging rats facing a ‘predatory’ threat
Current Biology, 2015 Fear is an adaptive mechanism evolved to influence the primal decisions of foragers in "approach resource-avoid predator" conflicts. To survive and reproduce, animals must attain the basic needs (food, water, shelter, and mate) while avoiding the ...
Eun Joo Kim +5 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source