Results 131 to 140 of about 8,800,807 (297)

Observational activation of anterior cingulate cortical neurons coordinates hippocampal replay in social learning

open access: yeseLife
Social learning enables a subject to make decisions by observing the actions of another. How neural circuits acquire relevant information during observation to guide subsequent behavior is unknown.
Xiang Mou, Daoyun Ji
doaj   +1 more source

Instructor interview for Place-Based WAC/WID writing instruction in English, clip 8 of 12

open access: yes, 2015
This item includes a segment of an instructor interview in a Writing Intensive course in English at the University of Hawaiʻi at Mānoa. The interview was conducted in 2014, and in this clip the interviewee is responding to the question 'If relevant, can ...
Place-based WAC/WID Hui
core  

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Evidence of spatial periodic firing in the subiculum of mice

open access: yesFrontiers in Neural Circuits
The subiculum is a critical node of the hippocampal formation, integrating multiple circuits—including thalamic inputs and afferents from CA1 and medial entorhinal cortex—and projecting broadly to cortical and subcortical targets. Yet its contribution to
P. Abad-Perez   +19 more
doaj   +1 more source

Instructor interview for Place-Based WAC/WID writing instruction in English, clip 12 of 12

open access: yes, 2015
This item includes a segment of an an instructor interview in a Writing Intensive course in English at the University of Hawaiʻi at Mānoa. The interview was conducted in 2014 and in this clip the interviewee is explaining the concept of muliwai.Brief ...
Place-based WAC/WID Hui
core  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

A contextual fear conditioning paradigm in head-fixed mice exploring virtual reality

open access: yeseLife
Contextual fear conditioning (CFC) is a classical laboratory task that tests associative memory formation and recall. Techniques such as multi-photon microscopy and holographic stimulation offer tremendous opportunities to understand the neural ...
Seetha Krishnan   +5 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

PLACE Events Fall 2013 [PDF]

open access: yes, 2013
This document describes PLACE events at Linfield College for fall ...
PLACE
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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