Results 191 to 200 of about 5,637,228 (331)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Association between the different basic activities of daily living on the Barthel index and community living, use of mobility aids, and the survival at 5 years. [PDF]

Front Public Health
Martín Moreno V, Pérez Rico E, Martín Fernández A, Hurtado Gallar J, Sánchez González I, Sánchez Rodríguez E, Martínez Sanz MI, Fernández Gallardo M, Marcos Guerra J, Cubero Sobrados MDC, Flórez Busto L, García Mateos A, Alonso Serna B, Vásquez Alay AL.   +13 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Investigating the Influence of Farmers’ Connectedness to Nature and Place Attachment on Soil Conservation Practices in Thailand

Ianna Journal of Interdisciplinary Studies
Background: Soil erosion, which causes land degradation, is negatively impacting the world's agriculture and food security. Conservation of soil fertility is thus crucial for sustainable land and agricultural production. Several previous research works,
Wanippol Mahaarcha, Somsak Amornsiriphong, Yuthpong Chantrawarin   +2 more
doaj  

Factors influencing herders' willingness to engage in grassland ecological restoration in Ruoergai County. [PDF]

Sci Rep
Shen C, Wang K, Huang L, Chen Z, Yuan H, Zheng L.   +5 more
europepmc   +1 more source

Corporate Germany Between Globalization and Regional Place Dependence: Business Restructuring in the Ruhr Area

, 2001
C. Berndt
semanticscholar   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Prevalence, knowledge, attitude, and practice of vaping among university students in the United Arab Emirates: a cross-sectional study. [PDF]

Front Public Health
Shuaib Azeez Z, Al Tawbah L, Imad L, Zino E, Baradie A, Hasan S, Matar J, Kassem NM, Hallit S, Malaeb D.   +9 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Exploring the influence of locality on stakeholder behavioral intentions in industrial heritage tourism from a sense of place perspective. [PDF]

Sci Rep
Chen H, Mei Y.
europepmc   +1 more source