Results 231 to 240 of about 1,871,533 (295)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Exocrine Pancreatic Insufficiency Manifesting Before Insulin Dependence in Adult-Onset Type 1 Diabetes. [PDF]

Clin Case Rep
Pavlou P, Pandit S, Karalliedde J.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Ivermectin attenuates nicotine-induced reward-like behaviors in mice. [PDF]

Biomol Biomed
Demirel ME, Ekici A, Yunusoğlu O.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Generalized 3D quasi-phase-matching model of image contrast in second harmonic generation microscopy of fibrillar collagen architectures. [PDF]

JPhys Photonics
Shelton EM, Campagnola PJ.
europepmc   +1 more source

The association between trait emotional intelligence and the quality of life of stroke patients: the mediating role of resilience. [PDF]

BMC Psychol
Wang X, Liu Y, Zhang X, Zhang J, Lin X.
europepmc   +1 more source

Clinical and sociodemographic determinants influencing caregiver burden in methamphetamine use disorder. [PDF]

Sci Rep
Mohamad Kutty R, Wahab S, Mohamad Isa MF.   +2 more
europepmc   +1 more source

Factors Associated With Cocaine Use Disorder: Results From the French Nationwide Repeated Cross-Sectional OPPIDUM Study (2019-2023). [PDF]

Fundam Clin Pharmacol
Alhamidi Z, Lacroix C, Jouve E, Soeiro T, Eiden C, Micallef J.   +5 more
europepmc   +1 more source

Impact of gap anisotropy of Polar and Anderson-Brinkman-Morel p-wave superconductors on thermoelectric properties of quantum dot hybrids. [PDF]

Sci Rep
Sonar V, Trocha P.
europepmc   +1 more source