Results 51 to 60 of about 554,526 (268)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Measuring place branding strategy implementation
, 2023 Place branding caught significant attention both among researchers and practitioners in the last decades, moving from corporate branding and marketing concept to a more multidisciplinary approach. Being an influential part of new public management, urban
Bruni, Roberto, Rauhut Kompaniets, Olga
core +1 more source
Die plek en funksie van ’n projek-bestuursmodel in ’n makrogemeente
HTS Teologiese Studies/Theological Studies, 2003 The place and function of a project management model in a macro-congregation The article aims to provide in the need for a project management model for efficient and effective congregation management, following the shift from a modern to a postmodern ...
A.A. van den Berg
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Production Engineering ArchivesAn Information Security Management System (ISMS) compliant with ISO/IEC 27001 requires the development and implementation of an effective system to guarantee the protection of information from threats.
Pacana Andrzej, Czerwińska Karolina
doaj +1 more source
Problemy Zarządzania, 2016 The article presents the preliminary results of empirical studies concerning the relationship between knowledge management and effective performance in small and medium enterprises.
Krzysztof Brzostek, Anna Michna
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
International Tax Planning: The Concept of Place of Effective Management
, 2014 This dissertation will study certain aspects of the South African Income Tax Act2 such as residence-based concepts, with specific reference to place of effective management, which brings a taxpayer within the ambit of the South African Tax Law.
Goosen, Chantelle
core
A Fuzzy-AHP-Based Decision Support System for Maintenance Strategy Selection in Facility Management
, 2017 In facility management, maintenance plays an important role in the sustainable development of buildings, involving safety, technical, economic and environmental aspects.
Pun, K. P. +9 more
core +1 more source