Results 151 to 160 of about 522,910 (321)
GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration
Alzheimer's &Dementia, EarlyView.Abstract INTRODUCTION We examined how abnormal prefrontal neurophysiology and changes in gamma‐aminobutyric acid‐ergic (GABAergic) neurotransmission contribute to behavioral impairments in disorders associated with frontotemporal lobar degeneration (FTLD). METHODS We recorded magnetoencephalography during an adaptive visuomotor task from 11 people with
Laura E. Hughes +11 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1331-1346, December 2022., 2022 Abstract Background Although programmed cell death 1 (PD‐1) blockade plus chemotherapy can significantly prolong the progression‐free survival (PFS) and overall survival (OS) in first‐line settings in patients with driver‐negative advanced non‐small‐cell lung cancer (NSCLC), the predictive biomarkers remain undetermined.
Fengying Wu +39 more
wiley +1 more source
Annals of Neurology, EarlyView.Objective The Clarity AD phase III trial showed that lecanemab reduced amyloid markers in early Alzheimer's disease (AD) and resulted in less decline on measures of cognition and function than placebo. Herein, we aimed to characterize amyloid‐β (Aβ) protofibril (PF) captured by lecanemab in human cerebrospinal fluid (CSF) from living participants with ...
Moeko Noguchi‐Shinohara +8 more
wiley +1 more source
Brain Metabolic Features of FUS‐ALS: A 2‐[18F]FDG‐PET Study
Annals of Neurology, EarlyView.Objective We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). Methods We employed the 2‐sample t‐test model of SPM12, implemented in MATLAB, to compare 12 FUS‐ALS ...
Antonio Canosa +24 more
wiley +1 more source
Interleukin 6/gp130 axis promotes neural invasion in pancreatic cancer
Cancer Medicine, Volume 11, Issue 24, Page 5001-5012, December 2022., 2022 Nerve invasion (N‐inv) is an important prognostic factor in pancreatic ductal adenocarcinoma (PDAC). To elucidate circulating stimulators for nerve invasion, the authors evaluated the stimulant activity and the inhibitory effects of IL‐6/gp130 axis. Biological activity of IL‐6/gp130 axis promoted nerve invasion in murine model and was upregulated in ...
Hidetaka Suzuki +9 more
wiley +1 more source
Annals of Neurology, EarlyView.GBA1 variants and decreased glucocerebrosidase activity are implicated in Parkinson's disease (PD). We investigated the hypothesis that increased levels of glucosylceramide (GlcCer), a main substrate of glucocerebrosidase, are involved in PD pathogenesis.
Emma N. Somerville +13 more
wiley +1 more source
PETHIDINE COMPARED WITH PETHIDINE PLUS LEVALLORPHAN AND WITH A PLACEBO
, 1965 P J Tomlin
openalex +1 more source
A PLACEBO‐CONTROLLED COMPARISON OF THE SEDATIVE PROPERTIES OF THREE BENZODIAZEPINES, LORAZEPAM, FLUNITRAZEPAM AND FOSAZEPAM [PDF]
, 1977 J. W. Dundee +4 more
openalex +1 more source
Arthritis &Rheumatology, EarlyView.Objective Adult‐onset Still disease (AOSD) is a systemic autoinflammatory disorder (AID) of unknown etiology. Genetic studies have been limited. Here, we conducted detailed genetic and inflammatory biomarker analysis of a large cohort with AOSD to investigate the underlying pathology and identify novel targets for potential treatment.
Joanne Topping +20 more
wiley +1 more source