HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study. [PDF]
, 2019 BACKGROUND AND OBJECTIVES: There is a need for local anesthetics that provide consistent analgesia through 72 hours after surgery. This study evaluates the use of HTX-011 (bupivacaine and meloxicam in Biochronomerpolymer technology), an extended-release,
Gimbel, Joseph S. +4 more
core +1 more source
Therapeutic targeting of myeloid cells in liver fibrosis: Mechanisms and clinical prospects
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the origin, recruitment, and differentiation regulation mechanisms of myeloid cells in driving hepatic fibrosis progression. By targeting these three critical phases, potential therapeutic strategies for liver fibrosis can be explored.
Yue Wang +5 more
wiley +1 more source
Adjuvant Pembrolizumab versus Placebo in Resected Stage III Melanoma
New England Journal of Medicine, 2018 A. Eggermont +28 more
semanticscholar +1 more source
Annals of Neurology, EarlyView.Objective The objective of this study was to show the capacity of structural brain magnetic resonance imaging (MRI) measures to serve as monitoring biomarkers for Fragile X‐Associated Tremor/Ataxia Syndrome (FXTAS). Methods From 2 longitudinal studies of male FMR1 premutation carriers, 2 brain MRI scans were selected from each participant, collected ...
David Hessl +6 more
wiley +1 more source
A comparative study between the efficacy of systemic meglumine antimoniate therapy with standard or low dose plus oral omiprazole in the treatment of cutaneous leishmaniasis [PDF]
Journal of Vector Borne Diseases, 2008 Background & objectives: Pentavalent antimony compounds are the first line of drugs in the treatment of cutaneous leishmaniasis. However, because of their potential toxic effects, many investigations are performed to find an effective and safe treatment ...
M.A. Nilforoushzadeh +5 more
doaj
Erenumab in chronic migraine: Patient-reported outcomes in a randomized double-blind study. [PDF]
, 2019 OBJECTIVE: To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:
Cheng, Sunfa +10 more
core +1 more source
Maintenance digoxin after an episode of heart failure: placebo-controlled trial in outpatients. [PDF]
, 1977 Sylvia M. Dobbs +2 more
openalex +1 more source
New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond
Annals of Neurology, EarlyView.The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr. +2 more
wiley +1 more source
Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia
New England Journal of Medicine, 2017 D. Rolnik +19 more
semanticscholar +1 more source