Results 171 to 180 of about 1,192,795 (361)

Matured hop extract reduces body fat in healthy overweight humans: a randomized, double-blind, placebo-controlled parallel group study [PDF]

, 2015
Yumie Morimoto-Kobayashi, Kazuaki Ohara, Hiroshi Ashigai, Tomoka Kanaya, Kumiko Koizumi, Fumitoshi Manabe, Yuji Kaneko, Yoshimasa Taniguchi, Mikio Katayama, Yasuyuki Kowatari, Sumio Kondo   +10 more
openalex   +1 more source

Intranasal Seletracetam in a Patient with Reading Epilepsy: First‐in‐Human Use to Prevent Reflex Seizures

Annals of Neurology, EarlyView.
We report the first human use of intranasal seletracetam (SEL) to prevent reflex seizures. A patient with epilepsy with reading‐induced seizures on levetiracetam (3,000 mg/day) continued to experience reading‐induced focal seizures with preserved consciousness.
Matthias J. Koepp, Kai‐Nicolas Poppert, Thomas Felder, Aljoscha Thomschewski, Sandra Lafenthaler, Pavel Klein, Alexander Rotenberg, Wolfgang Löscher, Chris Rundfeldt, Eugen Trinka   +9 more
wiley   +1 more source

SUN-451 A Randomized-Withdrawal, Placebo-Controlled, Phase 3 Study to Assess the Efficacy and Safety of Selective Glucocorticoid Receptor Antagonist, Relacorilant, in Patients with Cushing Syndrome (GRACE Study)

, 2019
Richard J. Auchus, James W. Findling, Andreas Moraitis   +2 more
openalex   +1 more source

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

Annals of Neurology, EarlyView.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains a significant challenge.
Yue Qiao, Adrien Ter Schiphorst, Yi Xu, Jean‐Claude Baron, Wenbo Zhao   +4 more
wiley   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Two prophylactic pain management regimens for medical abortion ≤63 days' gestation with mifepristone and misoprostol: A multicenter, randomized, placebo-controlled trial

, 2021
Monica Dragoman, Daniel Grossman, My Huong Nguyen, Ndema Habib, Nathalie Kapp, Anand Tamang, Tshego Bessenaar, Lan Dung Duong, Jageshwor Gautam, Jean-Louis Yoko, Minh Nguyen Thi Hong, Metin Gülmezoglu   +11 more
openalex   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Mucosal‐Associated Invariant T Cells in Rheumatic Diseases

Arthritis &Rheumatology, EarlyView.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Effects of benfotiamine treatment over 12 months on morphometric, neurophysiological and clinical measures in type 2 diabetes patients with symptomatic polyneuropathy: a randomized, placebo-controlled, double-blind clinical trial (BOND study). [PDF]

BMJ Open Diabetes Res Care
Ziegler D, Sipola G, Strom A, Strassburger K, Jander L, Herder C, Knebel B, Reule C, Jaghutriz BA, Moreira Tupac Yupanqui AC, Icks A, Al-Hasani H, Roden M, Kuss O, Bönhof GJ.   +14 more
europepmc   +1 more source

Hypnotic analgesia and the placebo effect; controlling ischemic pain.

, 1982
Henderikus J. Stam
openalex   +2 more sources