Results 171 to 180 of about 1,543,966 (410)

Targeting Mast Cell Activation and MIF‐Mediated Remodelling Enhances Chemotherapy Response in Pancreatic Cancer

Advanced Science, EarlyView.
Neoadjuvant gemcitabine plus nab‐paclitaxel (AG) reprograms pancreatic ductal adenocarcinoma by shifting malignant cells toward a classical phenotype and remodeling the tumor microenvironment. Despite enhancing cytotoxic NKT cells, AG activates tumor‐associated mast cells (TAMCs) and inflammatory CAFs through MIF signaling.
Libo Wang, Guangcong Shen, Guanpeng Xie, Zekun Li, Xiaoqing Ma, Mengyu Li, Ziyun Liu, Yadi Wang, Zongjing Lv, Qingxiao Fang, Huihui Sun, Ningning Zhao, Chao Yang, Tianxing Zhou, Yongjie Xie, Jun Yu, Jihui Hao   +16 more
wiley   +1 more source

Presenting a sham treatment as personalised increases the placebo effect in a randomised controlled trial

, 2023
Dasha A. Sandra, Jay A. Olson, Ellen J. Langer, Mathieu Roy   +3 more
openalex   +1 more source

Effects of remote ischemic conditioning on conditioned pain modulation and cardiac autonomic modulation in women with knee osteoarthritis: placebo-controlled randomized clinical trial protocol [PDF]

, 2023
Taíse Mendes Biral, Allysiê Priscilla de Souza Cavina, Eduardo Pizzo, Carlos Alberto Toledo Teixeira Filho, Franciele Marques Vanderlei   +4 more
openalex   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

Efficacy of Cheiranthus Cheiri in the Treatment of Pericoronitis: A Double-blind, Randomized, Placebo-controlled Trial with Molecular Docking

Dentistry and Medical Research
Context: Pericoronitis is the soft-tissue inflammation surrounding the dental crown in a semi-erupted lower third molar. Patients with early-stage pericoronitis experience discomfort, redness, swelling, mucosal ulceration, and loss of function.
Shubhamoy Ghosh, Aritra Roy Chowdhury, Sarbendu Paul, Avipsha Sarkar, Abhijit Rana, Mousumi Koley, Indrani Halder, Suman Chandra, Subhranil Saha   +8 more
doaj   +1 more source

Placebo or no placebo? [PDF]

Nature, 1990
openaire   +1 more source

Effects of Placebo Interventions on Subjective and Objective Markers of Appetite–A Randomized Controlled Trial [PDF]

, 2018
Verena Hoffmann, Marina Lanz, Jennifer Mackert, Timo D. Müller, Matthias H. Tschöp, Karin Meißner   +5 more
openalex   +1 more source

A Virtual Clinical Trial of Psychedelics to Treat Patients With Disorders of Consciousness

Advanced Science, EarlyView.
Disorders of consciousness after severe brain injury are marked by reduced complexity of brain activity and limited treatment options. Using personalized whole‐brain models, this study shows that simulated lysergic acid diethylamide (LSD) and psilocybin shift patient brain dynamics closer to criticality.
Naji L.N. Alnagger, Paolo Cardone, Charlotte Martial, Yonatan Sanz Perl, Iván Mindlin, Jacobo D Sitt, Leor Roseman, Robin Carhart‐Harris, David Nutt, Pablo Mallaroni, Natasha Mason, Johannes G Ramaekers, Vincent Bonhomme, Steven Laureys, Gustavo Deco, Olivia Gosseries, Pablo Núñez, Jitka Annen   +17 more
wiley   +1 more source

Treatment of cognitive impairment in patients with cerebral infarction in the internal carotid arteries circulation system: results of a multicentre, randomized, double-blind, placebo-controlled clinical trial

Неврология, нейропсихиатрия, психосоматика
Objective: to evaluate the efficacy and safety of the Prospecta drug in the treatment of cognitive impairment (CI) in patients with ischemic stroke (IS) in the carotid vascular territory.Material and methods.
D. R. Khasanova, A. A. Yakupova, P. R. Kamchatnov, Zh. Yu. Chefranova, E. I. Bogdanov, P. I Pilipenko, N. M. Khasanova   +6 more
doaj   +1 more source

A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy

, 2008
Justin M. Skripak, Scott D. Nash, Hannah Rowley, Nga Brereton, Susan Oh, Robert G. Hamilton, Elizabeth C. Matsui, A. Wesley Burks, Robert A. Wood   +8 more
openalex   +2 more sources