Results 11 to 20 of about 888,393 (367)

Updated Analysis From KEYNOTE-189: Pembrolizumab or Placebo Plus Pemetrexed and Platinum for Previously Untreated Metastatic Nonsquamous Non-Small-Cell Lung Cancer.

open access: yesJournal of Clinical Oncology, 2020
PURPOSE In KEYNOTE-189, first-line pembrolizumab plus pemetrexed-platinum significantly improved overall survival (OS) and progression-free survival (PFS) compared with placebo plus pemetrexed-platinum in patients with metastatic nonsquamous non‒small ...
S. Gadgeel   +25 more
semanticscholar   +1 more source

Lack of Effects of the Presence of a Dog on Pain Perception in Healthy Participants—A Randomized Controlled Trial

open access: yesFrontiers in Pain Research, 2021
Animal-assisted interventions (AAIs) have been shown to be effective in the treatment of pain. Studies suggest that relationships with animals can have comparable qualities to relationships with humans and that this enables animals to provide social ...
Cora Wagner   +8 more
doaj   +1 more source

Mediation Analyses for the Effect of Antibodies in Vaccination [PDF]

open access: yesJournal of Causal Inference, 2024, 12:20220043, 2022
We review standard mediation assumptions as they apply to identifying antibody effects in a randomized vaccine trial and propose new study designs to allow identification of an estimand that was previously unidentifiable. For these mediation analyses, we partition the total ratio effect (one minus the vaccine effect) from a randomized vaccine trial ...
arxiv   +1 more source

Effects of Coloring Food Images on the Propensity to Eat: A Placebo Approach With Color Suggestions

open access: yesFrontiers in Psychology, 2020
BackgroundResearch findings on the appetite-enhancing effect of the color red and the appetite-reducing effect of blue have been inconsistent. The present study used a placebo approach and investigated whether verbal suggestions can enhance color ...
Carina Schlintl, Anne Schienle
doaj   +1 more source

Preoperative optimization of cardiac valve patients’ expectations: Study protocol of the randomized controlled ValvEx-trial

open access: yesFrontiers in Cardiovascular Medicine, 2023
IntroductionComplete recovery after surgery depends on psychological factors such as preoperative information, expectations, and surgery-associated anxiety.
Nicole Horn   +11 more
doaj   +1 more source

When a placebo is not a ‘placebo’: a placebo effect on postprandial glycaemia [PDF]

open access: yesBritish Journal of Clinical Pharmacology, 2007
What is already known about this subject • Although placebo effects have been shown on subjective continuous variables such as pain, placebo effects on objective continuous variables remain uncertain.• The present, pilot, follow‐up investigation represents the first to assess a placebo effect on the objective continuous measurement of acute ...
Vladimir Vuksan   +3 more
openaire   +3 more sources

Pembrolizumab or Placebo Plus Etoposide and Platinum as First-Line Therapy for Extensive-Stage Small-Cell Lung Cancer: Randomized, Double-Blind, Phase III KEYNOTE-604 Study.

open access: yesJournal of Clinical Oncology, 2020
PURPOSE Pembrolizumab monotherapy has shown antitumor activity in patients with small-cell lung cancer (SCLC). The randomized, double-blind, phase III KEYNOTE-604 study compared pembrolizumab plus etoposide and platinum (EP) with placebo plus EP for ...
C. Rudin   +20 more
semanticscholar   +1 more source

Open-label versus double-blind placebo treatment in irritable bowel syndrome: study protocol for a randomized controlled trial

open access: yesTrials, 2017
Background Placebo medications, by definition, are composed of inactive ingredients that have no physiological effect on symptoms. Nonetheless, administration of placebo in randomized controlled trials (RCTs) and in clinical settings has been ...
Sarah Ballou   +12 more
doaj   +1 more source

Effects of placebos vs. SMS reminders on homework compliance in cognitive behavioral therapy for depression: a randomized trial

open access: yesMediterranean Journal of Clinical Psychology, 2022
Background: Nonadherence to homework assignments is a frequent problem among patients with depression during cognitive-behavioral therapy (CBT). The present study investigated the effects of two additional treatment components of CBT: a placebo and SMS ...
Nina Jurinec, Anne Schienle
doaj   +1 more source

Post-Depletion Aggression Restrained: Replicabilityof Brief Mindfulness Induction In Indonesian Sample

open access: yesJurnal Psikologi, 2019
Mindfulness practice is being promoted in Western countries as a means to improve one’s ability to restrain aggression under the “depleted” condition. The applicability of this framework in non-Western settings is yet to be determined. In this experiment
Cleoputri Al Yusainy, Wahyu Wicaksono
doaj   +1 more source

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