Results 251 to 260 of about 1,192,795 (361)

Effects of photobiomodulation therapy combined with static magnetic field on training adaptations and detraining responses: a randomised placebo-controlled trial. [PDF]

BMJ Open Sport Exerc Med
de Paiva PRV, Tomazoni SS, Machado CDSM, Pereira AL, Ribeiro NF, Lino MMA, Dias LB, de Oliveira MFD, de Araújo-Silva OM, Dorneles MP, Vanin AA, Baroni BM, Bjordal JM, Casalechi HL, Leal-Junior ECP.   +14 more
europepmc   +1 more source

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

Probiotic Supplementation With <i>Bifidobacterium longum</i> Subsp. <i>Longum</i> BL21 Improves Glycemic Control and Modulates Gut Microbiota in Type 2 Diabetes: A Randomized Controlled Trial. [PDF]

Food Sci Nutr
Zhu C, Liu Y, Chen Y, Wang Z, Gao Y, Xu F, Huang J.   +6 more
europepmc   +1 more source

A double-blind, placebo-controlled study of the safety and efficacy of ipratropium bromide nasal spray versus placebo in patients with the common cold

, 1992
Robert J. Dockhorn, Jay Grossman, Martin A. Posner, Miguel A. Zinny, D. Tinkleman   +4 more
openalex   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Pain relief by targeting nonrestorative sleep in fibromyalgia: a phase 3 randomized trial of bedtime sublingual cyclobenzaprine. [PDF]

Pain Med
Lederman S, Arnold LM, Vaughn B, Engels JM, Kelley M, Sullivan GM.   +5 more
europepmc   +1 more source

N‐of‐1 trials in clinical research: Methodological foundations, statistical approaches and implementation challenges

British Journal of Clinical Pharmacology, EarlyView.
N‐of‐1 trials offer a unique and rigorous methodology for evaluating individualized treatment responses, particularly within the context of personalized medicine. This article provides a comprehensive explanation of the conceptual and methodological underpinnings of N‐of‐1 trials, with particular emphasis on statistical techniques and considerations ...
Marcos Clint Leal De Carvalho, Matheus de Matos Dourado Simões, Ubiratan Cardinalli Adler, Antonio Brazil Viana Junior, Caren Nádia Soares de Sousa, Lia Lira Olivier Sanders   +5 more
wiley   +1 more source

Risks encountered when not adjusting for diurnal variation and food effect in QTcF analysis based on phase I data. [PDF]

J Pharmacokinet Pharmacodyn
Bardol M, Henrich A, Sarr C, Mezzalana E, Langenhorst J.   +4 more
europepmc   +1 more source