Results 61 to 70 of about 935,031 (288)

Preventive skin analgesia with lidocaine patch for management of post‐thoracotomy pain: Results of a randomized, double blind, placebo controlled study

Thoracic Cancer, 2019
Background To evaluate whether pre‐emptive skin analgesia using a lidocaine patch 5% would improve the effects of systemic morphine analgesia for controlling acute post‐thoracotomy pain.
Alfonso Fiorelli, Caterina Pace, Roberto Cascone, Annalisa Carlucci, Emanuele De Ruberto, Anna Cecilia Izzo, Beatrice Passavanti, Paolo Chiodini, Vincenzo Pota, Caterina Aurilio, Mario Santini, Pasquale Sansone   +11 more
doaj   +1 more source

Spatial Proteomics Identifies Distinct Synovial Microenvironments in Hip and Knee Osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objective Osteoarthritis (OA) is a heterogeneous joint disease, yet mechanistic insights derive predominantly from knee OA and are often extrapolated to other joints. We investigated joint‐associated differences in the spatial molecular organization of hip and knee OA synovium.
Peng Xie, Antonia R. Sun, Zhengtan Zheng, Yunkun Qu, Feng Gao, Christina Theodoropoulos, Nicholas Matigian, Zhiyong Li, Ross Crawford, Indira Prasadam   +9 more
wiley   +1 more source

Gabapentin as an add‐on analgesic to morphine in paediatric patients with chronic pain

British Journal of Clinical Pharmacology, EarlyView.
Aims Off‐label use of gabapentin for the treatment of chronic pain in children has increased over the last decade, with multiple clinical trials evaluating its role pain management and potential opioid‐sparing effects. To date, however, these studies appear to rely on empirical evidence without further consideration of pharmacokinetic‐pharmacodynamic ...
Paul Healy, Mariagrazia Felisi, Adriana Ceci, Oscar Della Pasqua, on Behalf of the GAPP Consortium, Corinne Alberti, Donato Bonifazi, Adriana Ceci, Thomas G. de Leeuw, Saskia N. de Wildt, Mariagrazia Felisi, Florentia Kaguelidou, Enora Le Roux, Rebecca Lundin, Laura Mangiarini, Dick Tibboel   +15 more
wiley   +1 more source

Rewarded placebo analgesia: A new mechanism of placebo effects based on operant conditioning

European Journal of Pain, 2019
Placebo analgesia is explained by two learning processes: classical conditioning and observational learning. A third learning process, operant conditioning, has not previously been investigated as a mechanism of placebo effects.
W. Adamczyk, Karolina Wiercioch-Kuzianik, E. Bajcar, P. Bąbel   +3 more
semanticscholar   +1 more source

Placebo use in the United Kingdom: results from a national survey of primary care practitioners [PDF]

, 2013
Objectives: Surveys in various countries suggest 17% to 80% of doctors prescribe ‘placebos’ in routine practice, but prevalence of placebo use in UK primary care is unknown.Methods: We administered a web-based questionnaire to a representative sample of ...
Stevens, Sarah, Wolstenholme Jane, Louhiala, Pekka, Sarah Stevens, Hemilä, Harri, Bishop, F.L, George Lewith, Hobbs F. D. Richard, Hobbs, F.D.R., Carl Heneghan, Stevens Sarah, Jeremy Howick, Lewith, George T., Felicity L Bishop, F D Richard Hobbs, Heneghan, C., Wolstenholme, J., Bishop Felicity L., Howick, J., Howick Jeremy, Heneghan Carl, Puustinen, Raimo, Lewith George, Jane Wolstenholme, F. D. Richard Hobbs, Felicity L. Bishop   +25 more
core   +1 more source

Histamine and the mechanisms of nausea and vomiting: Translating the uncertain pharmacology of cyclizine

British Journal of Clinical Pharmacology, EarlyView.
Abstract Cyclizine is a long‐established, short‐acting drug, registered for preventing motion sickness, post‐operative nausea and vomiting (PONV) and ‘vomiting of known cause’. The latter is not defined but may include pregnancy and patients receiving palliative care, historically accepted without large, controlled trials.
Gareth J. Sanger, Paul L. R. Andrews
wiley   +1 more source

Modeling Learning Patterns to Predict Placebo Analgesic Effects in Healthy and Chronic Orofacial Pain Participants

Frontiers in Psychiatry, 2020
Successfully predicting the susceptibility of individuals to placebo analgesics will aid in developing more effective pain medication and therapies, as well as aiding potential future clinical use of placebos. In pursuit of this goal, we analyzed healthy
Yang Wang, Yang Wang, Christina Tricou, Nandini Raghuraman, Titilola Akintola, Nathaniel R. Haycock, Maxie Blasini, Jane Phillips, Shijun Zhu, Luana Colloca, Luana Colloca, Luana Colloca   +11 more
doaj   +1 more source

Can an educational handout enhance placebo analgesia for experimentally-induced pain? [PDF]

PLoS ONE, 2013
The placebo effect is an interesting phenomenon whereby a dummy treatment can produce therapeutic benefit, such as, pain relief. While evidence for the placebo effect is growing, relatively few studies have explored ways of enhancing placebo effects.
Chi Wang Tang, Ben Colagiuri
doaj   +1 more source

Real Bodies Not Required? Placebo Analgesia and Pain Perception in Immersive Virtual and Augmented Reality

, 2022
Pain represents an embodied experience, wherein inferences are not only drawn from external sensory inputs, but also from bodily states. Previous research has demonstrated that a placebo administered to an embodied rubber hand can effectively induce ...
Lesur, Marte Roel, Saetta, Gianluca; https://orcid.org/, Krummenacher, Peter, Ho, Jasmine T, Lenggenhager, Bigna; https://orcid.org/   +4 more
core   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source