Hepatology, EarlyView., 2022 CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli +13 more
wiley +1 more source
‘External timing’ of placebo analgesia in an experimental model of sustained pain
European Journal of Pain, 2021 Research on placebo analgesia commonly focuses on the impact of information about direction (i.e., increase or decrease of pain) and magnitude of the expected analgesic effect, whereas temporal aspects of expectations have received little attention so ...
Eleanora Camerone +6 more
semanticscholar +1 more source
The Lancet, 2023 BACKGROUND Opioid analgesics are commonly used for acute low back pain and neck pain, but supporting efficacy data are scarce. We aimed to investigate the efficacy and safety of a judicious short course of an opioid analgesic for acute low back pain and ...
Caitlin M. P. Jones +8 more
semanticscholar +1 more source
Failure of Placebo Analgesia Model in Rats with Inflammatory Pain [PDF]
Neurosci Bull, 2019 Xiang-Sha Yin +3 more
semanticscholar +2 more sources
Placebo effect of an inert gel on experimentally induced leg muscle pain. [PDF]
, 2010 Purpose: This study examined the therapeutic effects of an inert placebo gel on experimentally induced muscle pain in a sports therapy setting. It aimed to investigate the degree to which conditioned analgesia, coupled with an expectation of intervention,
Coleman, Damian A +4 more
core +1 more source
Effect of Oral Pregabalin as Preemptive Analgesic in Patients Undergoing Lower Limb Orthopedic Surgeries under Spinal Anaesthesia [PDF]
Journal of Clinical and Diagnostic Research, 2016 Introduction: Conquering postoperative pain which has significant impact on the surgery outcome can be challenging for the clinicians. Pregabalin is a GABA analogue used for various neuropathic pain syndromes.
Bon Sebastian +3 more
doaj +1 more source
NeuroImage, 2021 The shared representations account of empathy suggests that sharing other people's emotions relies on neural processes similar to those engaged when directly experiencing such emotions.
Helena Hartmann +3 more
doaj +1 more source
Haemodynamic and Respiratory Effects of Dexmedetomidine as an Adjuvant to Oxycodone Patient-Controlled Analgesia After Lumbar Spinal Fusion: A Post Hoc Analysis of the DoseRespDex Randomised Controlled Trial. [PDF]
Acta Anaesthesiol ScandABSTRACT Purpose Dexmedetomidine has been studied as an adjunct to opioid patient‐controlled analgesia (PCA) because of its opioid‐sparing properties and limited respiratory depression. However, potential dose‐dependent haemodynamic effects should be considered, and data on dexmedetomidine administered via PCA remain limited.
Mäkelä S +5 more
europepmc +2 more sources
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Intracortical modulation, and not spinal inhibition, mediates placebo analgesia [PDF]
, 2014 Suppression of spinal responses to noxious stimulation has been detected using spinal fMRI during placebo analgesia, which is therefore increasingly considered a phenomenon caused by descending inhibition of spinal activity.
Lee, MCH +11 more
core +4 more sources