To respond or not to respond: exploring empathy-related psychological and structural brain differences between placebo analgesia responders and non-responders [PDF]
Frontiers in Psychology, 2023 IntroductionPlacebo responsiveness is highly variable across individuals. In the domain of pain, it may range from pronounced hypoalgesia to no response at all.
Helena Hartmann +5 more
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Neural effects of placebo analgesia in fibromyalgia patients and healthy individuals [PDF]
Pain, 2020 Placebo analgesia is hypothesized to involve top-down engagement of prefrontal regions that access endogenous pain inhibiting opioid pathways. Fibromyalgia (FM) patients have neuroanatomical and neurochemical alterations in pathways relevant to placebo ...
E. Frangos +7 more
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ERP Indicators of Self-Pain and Other Pain Reductions due to Placebo Analgesia Responding: The Moderating Role of the Fight-Flight-Freeze System [PDF]
Brain Sciences, 2021 This study evaluates the modulation of phasic pain and empathy for pain induced by placebo analgesia during pain and empathy for pain tasks. Because pain can be conceptualized as a dangerous stimulus that generates avoidance, we evaluated how approach ...
Arianna Vecchio, Vilfredo De Pascalis
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Dopamine has no direct causal role in the formation of treatment expectations and placebo analgesia in humans. [PDF]
PLoS BiologyDopamine-based reward and learning mechanisms have been suggested to contribute to placebo effects. However, the exact role of dopaminergic neurotransmission in their generation and maintenance is still unclear.
Angelika Kunkel +9 more
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Partial reinforcement, extinction, and placebo analgesia [PDF]
Pain, 2014 Numerous studies indicate that placebo analgesia can be established via conditioning procedures. However, these studies have exclusively involved conditioning under continuous reinforcement. Thus, it is currently unknown whether placebo analgesia can be established under partial reinforcement and how durable any such effect would be.
Au Yeung, ST +3 more
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Bayesian prediction of placebo analgesia in an instrumental learning model. [PDF]
PLoS ONE, 2017 Placebo analgesia can be primarily explained by the Pavlovian conditioning paradigm in which a passively applied cue becomes associated with less pain.
Won-Mo Jung +3 more
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Placebo analgesia persistence: evaluating behavioural stability in repeated trials [PDF]
Communications BiologyPlacebo analgesia is widely believed to rely on psychological, genetic, and biological factors. Whilst these factors have been assessed in single expressions of this phenomenon, few have documented its consistency over time, limiting understanding of its
Lewis S. Crawford +9 more
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NeuroImage: Clinical, 2018 Pain interventions with no active ingredient, placebo, are sometimes effective in treating chronic pain conditions. Prior studies on the neurobiological underpinnings of placebo analgesia indicate endogenous opioid release and changes in brain responses ...
Clas Linnman +6 more
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Brain network representations of placebo analgesia [PDF]
Psychological MedicineAbstract Background Prior neuroimaging studies and meta-analyses investigating brain correlates of placebo analgesia (PA) have yielded neuroanatomically heterogeneous findings, which may be reconciled from a connectomics perspective.
Xiaohan Zhang +9 more
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Placebo and Active Treatment Additivity in Placebo Analgesia: Research to Date and Future Directions
International Review of Neurobiology, 2018 Placebo analgesia is a robust experimental and clinical phenomenon. While our understanding of the mechanisms of placebo analgesia has developed rapidly, some central questions remain unanswered.
Bobby Zachariae +2 more
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