Advanced Science, EarlyView.Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu +5 more
wiley +1 more source
The placebo effect: I. Situational anxiety and model behavior [PDF]
, 1972 Bruce J. Morrison, Stephen B. Walters
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Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs. [PDF]
, 2018 PURPOSE: To evaluate the effects of eslicarbazepine acetate (ESL) on lipid metabolism and to determine whether reduced statin exposure during ESL therapy has clinical consequences. SUBJECTS AND METHODS: We conducted a post-hoc analysis of pooled data for
Ben-Menachem, Elinor +11 more
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The effect of atorvastatin on pancreatic beta cell requirement in women with polycystic ovary syndrome [PDF]
, 2017 Background There is an increased risk of developing T2DM in women with polycystic ovary syndrome (PCOS) and there is evidence that statins improve metabolic parameters in these patients.
Atkin, Stephen L. +3 more
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Advanced Science, EarlyView.Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu +9 more
wiley +1 more source
Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design. [PDF]
, 1984 Craig M. Pratt +9 more
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Advanced Science, EarlyView.This double‐blind, placebo‐controlled study demonstrates that intranasal oxytocin reduces subjective fear in immersive, naturalistic social (but not non‐social) contexts. Concomitant fMRI reveals that oxytocin enhances middle cingulate activity and amygdala connectivity while it modulates network‐level connectivity and attenuates reactivity of a brain ...
Kun Fu +17 more
wiley +1 more source
The Effect of Dydrogesterone on Premenstrual Symptoms:A Double-blind, Randomized, Placebo-controlled Study in General Practice [PDF]
, 1988 Vibeke Hoffmann +4 more
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Advanced Science, EarlyView.Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra +9 more
wiley +1 more source
Effect of picotamide on the clinical progression of peripheral vascular disease. A double-blind placebo-controlled study. The ADEP Group. [PDF]
, 1993 F Balsano, Francesco Violi
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