Results 101 to 110 of about 728,357 (259)

Erenumab in chronic migraine: Patient-reported outcomes in a randomized double-blind study. [PDF]

, 2019
OBJECTIVE: To determine the effect of erenumab, a human monoclonal antibody targeting the calcitonin gene-related peptide receptor, on health-related quality of life (HRQoL), headache impact, and disability in patients with chronic migraine (CM). METHODS:
Cheng, Sunfa, Desai, Pooja, Lenz, Robert, Leonardi, Dean K., Lipton, Richard B., Mikol, Daniel D., Nilsen, Jon, Reuter, Uwe, Silberstein, Stephen, Stewart, Walter F., Tepper, Stewart J.   +10 more
core   +1 more source

Efficacy and safety of dotinurad versus febuxostat for the treatment of gout: a randomised, multicentre, double‐blind, phase 3 trial in China

Arthritis &Rheumatology, Accepted Article.
Objectives Dotinurad is a selective urate reabsorption inhibitor that reduces serum urate levels. We compared the efficacy and safety of dotinurad with febuxostat in Chinese patients with gout. Methods This phase 3, multicentre, randomised, double‐blind, parallel‐group study randomly allocated (1:1) eligible patients with gout to receive oral dotinurad
Jia Sun, Yu Wang, Yongjing Cheng, Dongmei Guo, Jiankang Hu, Dongzhou Liu, Zhengnan Gao, Changgui Li, Yibing Lu, Xiaodan Kong, Yu Liu, Zhenyu Jiang, Bin Yi, Hongfeng Zhang, Baijie Xu, Shihao Yu, Rieko Kokan, Kohei Ishikawa, Mikiko Kawakatsu, Zhuoli Zhang   +19 more
wiley   +1 more source

The placebo effect shortens movement time in goal-directed movements. [PDF]

Sci Rep, 2022
Fiorio M, Villa-Sánchez B, Rossignati F, Emadi Andani M.   +3 more
europepmc   +1 more source

Peripheral blood gene expression profiling shows prognostic significance for the course of interstitial lung disease in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective We used data from the placebo arm of the SENSCIS trial to determine the prognostic/predictive significance of peripheral blood cell (PBC) transcript modules for the course of forced vital capacity (FVC) in patients with systemic sclerosis‐associated interstitial lung disease (SSc‐ILD) with and without mycophenolate mofetil (MMF) treatment ...
Shervin Assassi, Christopher P. Denton, Matthias Zwick, Ramona Schmid, Carina Ittrich, Tobias Litzenburger, Sudha Visvanathan   +6 more
wiley   +1 more source

MRI Quantification of Placebo Effect in Nonalcoholic Steatohepatitis Clinical Trials. [PDF]

Radiology, 2023
Nedrud MA, Chaudhry M, Middleton MS, Moylan CA, Lerebours R, Luo S, Farjat A, Guy C, Loomba R, Abdelmalek MF, Sirlin CB, Bashir MR.   +11 more
europepmc   +1 more source

A multi-site, double-blind, placebo-controlled pilot clinical trial to evaluate the efficacy of buspirone as a relapse-prevention treatment for cocaine dependence [PDF]

, 2014
Objective—To evaluate the potential efficacy of buspirone as a relapse-prevention treatment for cocaine dependence. Method—A randomized, double-blind, placebo-controlled, 16-week pilot trial conducted at six clinical sites between August 2012 and June ...
Chartier, Karen G., Douaihy, Antoine, Haynes, Louise, Hodgkins, Candace, Kropp, Frankie, Lindblad, Robert, Winhusen, Theresa M.   +6 more
core   +1 more source

The Inflation Reduction Act and Etanercept

Arthritis &Rheumatology, EarlyView.
Charles L. Bennett, Jason B. Gibbons, Chadi Nabhan, Kenneth R. Carson, June M. McKoy, Kevin B. Knopf, Gerald Anderson   +6 more
wiley   +1 more source

First‐in‐human safety, tolerability, pharmacokinetics and pilot food‐effect study of the candidate antimalarial compound MMV367

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim To evaluate the safety, tolerability and pharmacokinetics in healthy participants of orally administered MMV367 (GSK3772701), a novel antimalarial interfering with Plasmodium falciparum acyl coenzyme A synthetase 10/11 function. Methods This first‐in‐human study enrolled 47 healthy male and female participants.
Andrea Kuemmerle, Nand Singh, Denis Gossen, Annick Janin, Raman Sharma, Anthony Cahn, Rachel A. Gibson, Somasekhara R. Menakuru, Erin Lambourne, Tom Dove, Francisco‐Javier Gamo, Laura Sanz, Benoit Bestgen, Stephan Chalon   +13 more
wiley   +1 more source

n-3 PUFAs for depression: treatment effect or absence-of-placebo effect? [PDF]

Transl Psychiatry, 2022
Memarpouri A, van der Does W, Molendijk ML.   +2 more
europepmc   +1 more source

Free-Riding in the Lab and in the Field [PDF]

To investigate the external validity of laboratory results, we combine a public good experiment with three treatments in a field experiment. One treatment offers the opportunity to free-ride, the other two are placebo treatments.
Florian Englmaier, Georg Gebhardt
core