Results 101 to 110 of about 1,288,236 (382)

Neurobiology of Placebo Effect [PDF]

Psikiyatride Güncel Yaklaşımlar, 2013
Placebo is defined as a substance or method that has no specific effect on the condition being treated. Placebo leads to the state of contentment and shows its effects just like a drug by the pathways in the body. Various changes formed by plasebo on the
Suleyman Akarsu, Murat Erdem, Murat Gulsun   +2 more
doaj   +1 more source

Differentiated effects of the multimodal antidepressant vortioxetine on sleep architecture: Part 1, a pharmacokinetic/pharmacodynamic comparison with paroxetine in healthy men [PDF]

, 2015
We compared the effect of vortioxetine, paroxetine and placebo after three days of dosing on sleep architecture. This was a randomised, double-blind, four-way crossover, placebo-controlled, multiple-dose study in 24 healthy young men.
Areberg, J, Buchberg, J, Hojer, A-M, Nutt, DJ, Wilson, S   +4 more
core   +1 more source

The perils of Kremlin's influence: evidence from Ukraine [PDF]

arXiv, 2022
We examine the contribution of institutional integration to the institutional quality. To this end, we exploit the 2007 political crisis in Ukraine and examine the effects of staying out of the European Union for 28 Ukrainian provinces in the period 1996-2020. We construct novel subnational estimates of institutional quality for Ukraine and central and
arxiv  

Home‐Based Tele‐tDCS in Amyotrophic Lateral Sclerosis: Feasibility, Safety, and Preliminary Efficacy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options. Transcranial direct current stimulation (tDCS) shows promise as a neuromodulatory intervention in various neurological disorders, but its application in ALS, particularly in a remote, home‐based format, remains underexplored.
Sangeetha Madhavan, Shravni Deshmukh, Mark Cummings, Aditi Doshi, Kourosh Rezania, Sally Freels, Gina Sawa   +6 more
wiley   +1 more source

Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect

Frontiers in Psychiatry, 2019
Background: Recent research shows that placebo mechanisms can be utilized in ethical and legal ways such as in open-label conditions, when patients know that they receive placebos, and through psychological interventions aiming to optimize patients ...
Jens Hamberger, Jens Hamberger, Karin Meissner, Karin Meissner, Thilo Hinterberger, Thomas Loew, Katja Weimer   +6 more
doaj   +1 more source

Rolofylline, an adenosine A1−receptor antagonist, in acute heart failure [PDF]

, 2010
Background: Worsening renal function, which is associated with adverse outcomes, often develops in patients with acute heart failure. Experimental and clinical studies suggest that counterregulatory responses mediated by adenosine may be involved. We
Bloomfield, Daniel M., Cleland, John G.F., Cotter, Gad, DeLucca, Paul, Dittrich, Howard C., Givertz, Michael M., Mansoor, George A., Massie, Barry M., Metra, Marco, O'Connor, Christopher M., Ponikowski, Piotr, Salerno, Christina M., Teerlink, John R., Voors, Adriaan, Weatherley, Beth Davison   +14 more
core   +1 more source

Pharmacokinetics, Efficacy, and Safety of Upadacitinib in Pediatric Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis: An Interim Analysis of an Open‐Label, Phase 1 Trial

Arthritis Care &Research, EarlyView.
Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner, Anna Shmagel, Gerd Horneff, Ivan Foeldvari, Jordi Antón, Athimalaipet V. Ramanan, Yuli Qian, Kristina Unnebrink, Shuai Hao, Heidi S. Camp, Nasser Khan, Wei Liu, Mohamed‐Eslam F. Mohamed   +12 more
wiley   +1 more source

A systematic review of sex differences in the placebo and the nocebo effect

Journal of Pain Research, 2017
Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review ...
Vambheim SM, Flaten MA
doaj  

Optimal Model Selection in RDD and Related Settings Using Placebo Zones [PDF]

arXiv, 2022
We propose a new model-selection algorithm for Regression Discontinuity Design, Regression Kink Design, and related IV estimators. Candidate models are assessed within a 'placebo zone' of the running variable, where the true effects are known to be zero.
arxiv  

Relationship Between Gout Flare States and Patient‐Reported Outcomes After Allopurinol Initiation

Arthritis Care &Research, EarlyView.
Objective Gout flares are the most important clinical feature of the disease. A hypothetical maximum flare occurrence in the preceding six months has been suggested to be no flares for a patient‐acceptable symptom state (PASS) and only one flare for low disease activity (LDA).
Lisa K. Stamp, Chris Frampton, Sarah Stewart, Keith J. Petrie, N. Lawrence Edwards, Angelo Gaffo, Nicola Dalbeth   +6 more
wiley   +1 more source