Results 101 to 110 of about 398,598 (315)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

The effect of rizatriptan, ergotamine, and their combination on human peripheral arteries: a double‐blind, placebo‐controlled, crossover study in normal subjects [PDF]

, 2002
Peer Tfelt‐Hansen, Kaj N. Seidelin, Michael Stepanavage, Christopher Lines   +3 more
openalex   +1 more source

Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment

Advanced Science, EarlyView.
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr., Georgii B. Telegin, Aleksandr S. Chernov, Anna A. Kudriaeva, Alexey N. Minakov, Maksim V. Rodionov, Vitaly A. Kazakov, Viktor A. Palikov, Yuri M. Poluektov, Rustam H. Ziganshin, Daria A. Orlova, Alena S. Evpak, Daniil A. Barsuk, Fedor A. Mesheryakov, Aldo Spallone, Dmitry S. Asyutin, Igor N. Pronin, Nikolay A. Konovalov, Dmitri Yu Usachev, Alexander G. Gabibov, Alexander N. Konovalov   +20 more
wiley   +1 more source

Effects of deep brain stimulation and verbal suggestions on pain in Parkinson’s disease

Scandinavian Journal of Pain
In Parkinson’s disease (PD) patients, verbal suggestions have been shown to modulate motor and clinical outcomes in treatment with subthalamic deep brain stimulation (DBS). Furthermore, DBS may alleviate pain in PD.
Rosenkjær Sophie, Hvingelby Victor Schwartz, Johnsen Erik Lisbjerg, Møller Mette, Carlino Elisa, Jensen Troels Staehelin, Vase Lene   +6 more
doaj   +1 more source

The 'placebo effect' in the conservative treatment of plantar fasciitis: a systematic review and meta-analyses. [PDF]

EFORT Open Rev, 2023
Viglione V, Boffa A, Previtali D, Vannini F, Faldini C, Filardo G.   +5 more
europepmc   +1 more source

Efficacy, safety and effect on gene expression profiling of anakinra in systemic-onset juvenile idiopathic arthritis: final results of a randomised, double-blind, placebo-controlled trial (ANAJIS) [PDF]

, 2008
Pierre Quartier, Florence Allantaz, Rolando Cimaz, Pascal Pillet, Olivier Richer, Marine Desjonquères, A. Duquesne, Claude Messiaen, Christophe Bardin, X Bossuyit, Anne Boutten, J Bienvenu, Véronique Ménoni, S Sotou-Bere, Bénédicte Neven, N Mahloui, A. Mogenet, Behrouz Kassaï, Damien Chaussabel, Jean‐Marc Tréluyer, JL Bresson, Paul Landais, Virginia Pascual   +22 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Significance of Participants’ Expectations in Managing the Placebo Effect in Antidepressant Research

Frontiers in Psychiatry, 2019
Marko Curkovic, Marko Curkovic, Andro Kosec, Andro Kosec   +3 more
doaj   +1 more source

Effect of a Fermented Milk CombiningLactobacillus AcidophilusCL1285 andLactobacillus Caseiin the Prevention of Antibiotic-Associated Diarrhea: A Randomized, Double-Blind, Placebo-Controlled Trial [PDF]

, 2007
Mélanie Beausoleil, Nadia Fortier, Stéphanie Guénette, Amélie L’Ecuyer, Michel Savoie, Martin Franco, Jean Lachaîne, Karl Weiss   +7 more
openalex   +1 more source