Active-Controlled Trial Design for HIV Prevention Trials with a Counterfactual Placebo [PDF]
arXivIn the quest for enhanced HIV prevention methods, the advent of antiretroviral drugs as pre-exposure prophylaxis (PrEP) has marked a significant stride forward. However, the ethical challenges in conducting placebo-controlled trials for new PrEP agents against a backdrop of highly effective existing PrEP options necessitates innovative approaches ...
arxiv
Comparative effect of disopyramide and ethmozine in suppressing complex ventricular arrhythmias by use of a double-blind, placebo-controlled, longitudinal crossover design. [PDF]
, 1984 Craig M. Pratt +9 more
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Advanced Science, EarlyView.This work summarizes the efficacy and mechanisms of probiotics in CRC treatment, providing a comprehensive overview of various encapsulation methods such as microcapsules, hydrogels, single‐cell nanocoatings, and nanofibers for targeted probiotic delivery to inflammatory sites, with particular emphasis on the potential advantages of emerging single ...
Hao Zhong +5 more
wiley +1 more source
Frontiers in PsychologyIntroductionObservational learning (OL) refers to learning through observing other people’s behavior. OL has been suggested as an effective and simple tool to evoke treatment expectations and corresponding placebo and nocebo effects.
Helena Klauß +4 more
doaj +1 more source
Optimal Approximate Designs for Comparison with Control in Dose-Escalation Studies [PDF]
arXiv, 2015 Consider an experiment, where a new drug is tested for the first time on human subjects - healthy volunteers. Such experiments are often performed as dose-escalation studies: a set of increasing doses is pre-selected, individuals are grouped into cohorts, and in each cohort, the dose number $i$ can be administered only if the dose number $i-1$ has ...
arxiv
Estimating the treatment effect in a subgroup defined by an early post-baseline biomarker measurement in randomized clinical trials with time-to-event endpoint [PDF]
arXiv, 2018 Biomarker measurements can be relatively easy and quick to obtain and they are useful to investigate whether a compound works as intended on a mechanistic, pharmacological level. In some situations, it is realistic to assume that patients, whose post-baseline biomarker levels indicate that they do not sufficiently respond to the drug, are also unlikely
arxiv
Effect of picotamide on the clinical progression of peripheral vascular disease. A double-blind placebo-controlled study. The ADEP Group. [PDF]
, 1993 F Balsano, Francesco Violi
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Growth of Omnichannel Grocery Retailing and Food Prices
Agribusiness, EarlyView.ABSTRACT This paper examines the effects of the growth of omnichannel grocery retailing on food prices. We first develop a conceptual model of consumer choice and retailer pricing that allows us to evaluate changes in equilibrium prices, quantities, and profits with online channel growth and alternative pricing strategies.
Xiangwen Kong +2 more
wiley +1 more source
Putting climate change at the heart of education: Is England's strategy a placebo for policy?
British Educational Research Journal, Volume 48, Issue 6, Page 1083-1101, December 2022., 2022 Abstract In this paper we present an analysis of the sustainability and climate change strategy for education and children's services systems in England, produced by the Department for Education. Using critical discourse analysis, we juxtapose qualitative data collected from >200 youth teachers and teacher educators in the context of co‐creating a ...
Lynda Dunlop, Elizabeth A. C. Rushton
wiley +1 more source
Goodness‐of‐fit tests in proportional hazards models with random effects
Biometrical Journal, Volume 65, Issue 1, January 2023., 2023 Abstract This paper deals with testing the functional form of the covariate effects in a Cox proportional hazards model with random effects. We assume that the responses are clustered and incomplete due to right censoring. The estimation of the model under the null (parametric covariate effect) and the alternative (nonparametric effect) is performed ...
Wenceslao González‐Manteiga +2 more
wiley +1 more source