Results 101 to 110 of about 8,509,826 (346)

The relation of emotions to placebo responses [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2011
The hypothesis put forth is that expectations of treatment effects reduce negative emotions and thereby reduce symptoms, e.g. pain. Negative emotions increase pain, and it is hypothesized that placebos reduce pain by reducing negative emotions, i.e. feelings of nervousness, fear and anxiety.
Espen Bjørkedal, Peter Solvoll Lyby, Magne Arve Flaten, Per M. Aslaksen   +3 more
openaire   +3 more sources

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

Ultra-overt therapy: a novel medical approach centered on patient consciousness

Frontiers in Integrative Neuroscience
Within the realms of human and artificial intelligence, the concepts of consciousness and comprehension are fundamental distinctions. In the clinical sphere, patient awareness regarding medication and its physiological processes plays a crucial role in ...
Kamran Shirbache, Amirreza Liaghat, Sanam Saeifar, Ahmadreza Nezameslami, Ali Shirbacheh, Hamid Nasri, Hamidreza Namazi   +6 more
doaj   +1 more source

Identifying placebo responders and predictors of response in osteoarthritis: a protocol for individual patient data meta-analysis

Systematic Reviews, 2016
Background The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical trials
Yu Fu, Monica S. M. Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M. A. Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang   +9 more
doaj   +1 more source

Covariate Balancing Methods for Randomized Controlled Trials Are Not Adversarially Robust [PDF]

arXiv, 2021
The first step towards investigating the effectiveness of a treatment via a randomized trial is to split the population into control and treatment groups then compare the average response of the treatment group receiving the treatment to the control group receiving the placebo.
arxiv  

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

A systematic review of sex differences in the placebo and the nocebo effect

Journal of Pain Research, 2017
Sara M Vambheim,1 Magne Arve Flaten2 1Department of Psychology, UiT, The Arctic University of Norway, Tromsø, 2Department of Psychology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway Objectives: The present review ...
Vambheim SM, Flaten MA
doaj  

Clinical response to placebo botulinum toxin injection in cervical dystonia—a systematic review and meta-analysis

Dystonia
BackgroundCervical dystonia is the most common form of focal dystonia and is the most studied neurological condition in patients receiving botulinum toxin.
Emma Wetmore, Henry Roberts, Alicia A. Livinski, Terance Camacho, Chyanne Eaton, Gina Norato, Mark Hallett, Mark Stacy   +7 more
doaj   +1 more source

Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics

Advanced Healthcare Materials, EarlyView.
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Optimal Approximate Designs for Comparison with Control in Dose-Escalation Studies [PDF]

arXiv, 2015
Consider an experiment, where a new drug is tested for the first time on human subjects - healthy volunteers. Such experiments are often performed as dose-escalation studies: a set of increasing doses is pre-selected, individuals are grouped into cohorts, and in each cohort, the dose number $i$ can be administered only if the dose number $i-1$ has ...
arxiv