Vascular co‐option and vasculogenic mimicry mediate resistance to antiangiogenic strategies
Cancer Reports, Volume 5, Issue 12, December 2022., 2022 Abstract Background The concept that all the tumors need the formation of new vessels to grow inspired the hypothesis that inhibition of angiogenesis would have led to “cure” cancer. The expectancy that this type of therapy would have avoided the insurgence of resistance was based on the concept that targeting normal vessels, instead of the cancer ...
Francesco Pezzella, Domenico Ribatti
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Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 94-106, January 2023., 2023 Abstract Deutetrabenazine (Austedo) is indicated in adults for chorea associated with Huntington disease and tardive dyskinesia. Escalating deutetrabenazine doses were administered to healthy volunteers who were cytochrome P450 2D6 extensive/intermediate metabolizers (EMs) or poor metabolizers (PMs) to determine pharmacokinetic exposure of parent drug ...
Frank Schneider +7 more
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Active-Controlled Trial Design for HIV Prevention Trials with a Counterfactual Placebo [PDF]
arXivIn the quest for enhanced HIV prevention methods, the advent of antiretroviral drugs as pre-exposure prophylaxis (PrEP) has marked a significant stride forward. However, the ethical challenges in conducting placebo-controlled trials for new PrEP agents against a backdrop of highly effective existing PrEP options necessitates innovative approaches ...
arxiv
Predictors of placebo response in three large clinical trials of the V1a receptor antagonist balovaptan in autism spectrum disorder. [PDF]
Neuropsychopharmacology, 2023 Tobe R +6 more
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RESPONSES TO ANALGESICS AND PLACEBO—STATISTICAL ANALYSIS
, 1957 H.H. Keasling, E Gross
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Room C, 10/17/2000 2: 00 PM - 4: 00 PM (PS) Attenuating the Response to Intubation: Remifentanil, Esmolol and Placebo [PDF]
, 2000 Menno F. TerRiet +4 more
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Frontiers in NeuroscienceIntroductionAlcohol use disorder (AUD) occurs at higher rates in individuals with bipolar disorder compared to the general population. A paucity of data are available on specific mechanisms that may contribute to bipolar and AUD co-occurrence.
Elizabeth T. C. Lippard +21 more
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The Impact of Baseline Anxiety on Drug Placebo Separation and Drug/Placebo Response in an Acute Schizophrenia Clinical Trial-A Post-hoc Analysis. [PDF]
Schizophr Bull Open, 2023 Kott A, Brannan S, Wang X, Daniel D.
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Room B, 10/17/2000 9: 00 AM - 11: 00 AM (PS) Autonomic Responses to Thermal Stressors during Dexmedetomidine Versus Placebo Infusions in Volunteers [PDF]
, 2000 Charles W. Hogue +3 more
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Arthritis &Rheumatology, EarlyView.Objective Our objective was to evaluate the efficacy and safety of subcutaneous (SC) abatacept and standard of care (SOC) for the treatment of idiopathic inflammatory myopathy (IIM) over 52 weeks. Methods In this randomized, double‐blind, placebo‐controlled phase III trial, patients with treatment‐refractory IIM received SC abatacept (at 125 mg weekly)
Rohit Aggarwal +5 more
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