Placebos without deception reduce self-report and neural measures of emotional distress
Nature Communications, 2020 There is controversy about whether placebos without deception cause real psychobiological benefits. Here, the authors show that the positive effects of placebos without deception are more than response bias by providing evidence they can reduce self ...
Darwin A Guevarra +2 more
exaly +3 more sources
Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses
Brain Sciences, 2021 Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative ...
Michael Schaefer +2 more
doaj +2 more sources
Effects of open-label placebos in clinical trials: a systematic review and meta-analysis
Scientific Reports, 2021 Open-label placebos (OLPs) are placebos without deception in the sense that patients know that they are receiving a placebo. The objective of our study is to systematically review and analyze the effect of OLPs in comparison to no treatment in clinical ...
Stefan Schmidt
exaly +2 more sources
Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis. [PDF]
PLoS ONE, 2018 Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even ...
Michael Schaefer +2 more
doaj +2 more sources
Scientific Reports, 2021 Psychological distress is prevalent in students and can predispose to psychiatric disorders. Recent findings indicate that distress might be linked to impaired cognitive performance in students.
Julian Kleine-Borgmann
exaly +2 more sources
Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos [PDF]
Scientific ReportsRecent reports challenge the view that placebos need to be given in deception. Numerous studies report remarkable effects when giving placebos honestly in an open way. However, the mechanisms of open-label placebos still remain to be cleared. For example,
Michael Schaefer +2 more
doaj +2 more sources
Addressing blinding in classic psychedelic studies with innovative active placebos. [PDF]
Int J NeuropsychopharmacolClassic psychedelics have shown promise in the treatment of various neuropsychiatric disorders. However, weak blinding integrity has been argued to limit the interpretability of therapeutic effects observed in psychedelic clinical trials, highlighting ...
Aday JS +3 more
europepmc +2 more sources
Relieving pain using dose-extending placebos [PDF]
Pain, 2016 Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be ...
Colloca, Luana +2 more
core +2 more sources
BMC Psychiatry, 2020 Background The issue of unblinded outcome-assessors and patients has repeatedly been stressed as a flaw in allegedly double-blind antidepressant trials. Unblinding bias can for example result from a drug‘s marked side effects.
Lisa Holper, Michael P. Hengartner
doaj +2 more sources
A discursive exploration of public perspectives on placebos and their effects
Health Psychology Open, 2019 There is increasing evidence that placebos could be effective in clinical practice. However, knowledge of public perspectives on placebos is underdeveloped.
Doug I Hardman +4 more
doaj +2 more sources