Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos [PDF]
Scientific ReportsRecent reports challenge the view that placebos need to be given in deception. Numerous studies report remarkable effects when giving placebos honestly in an open way. However, the mechanisms of open-label placebos still remain to be cleared. For example,
Michael Schaefer +2 more
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Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos. [PDF]
PLoS ONE, 2012 BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Felicity L Bishop +3 more
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Magnitude of the Digital Placebo Effect and Its Moderators on Generalized Anxiety Symptoms: Systematic Review and Meta-Analysis [PDF]
Journal of Medical Internet ResearchBackground Digital therapeutics (DTx) have attracted attention as the substitutes or add-ons to conventional pharmacotherapy. The number of clinical trials for DTx has increased recently, and one of the main targets for DTx is psychiatric disorders ...
Takashi Hosono +3 more
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Ethical challenges of placebo use in herbal medicine trials: multiple stakeholder perspectives from qualitative interviews [PDF]
BMC Medical EthicsBackground The ethical use of placebos in herbal medicine (HM) clinical trials remains contested, particularly in contexts where traditional medical systems shape patients’ beliefs and expectations.
Yixuan Li +5 more
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Placebos without deception reduce self-report and neural measures of emotional distress
Nature Communications, 2020 There is controversy about whether placebos without deception cause real psychobiological benefits. Here, the authors show that the positive effects of placebos without deception are more than response bias by providing evidence they can reduce self ...
Darwin A Guevarra +2 more
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From catastrophizing to catalyzing: does pain catastrophizing modulate the beneficial impact of open-label placebos for chronic low back pain? A secondary analysis [PDF]
Frontiers in PsychologyChronic back pain (CBP) is a global health problem with significant health and economic consequences. Traditional analgesics are often no better than placebo, highlighting the need for biopsychosocial approaches.
Elif Buse Caliskan +6 more
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Noble Humbug? Hard and soft laws on clinical placebo use [PDF]
Frontiers in PsychologyDespite the widespread historical and contemporary use of placebos in medicine, legal regulations addressing their administration remain limited in many countries.
Mélina Richard +9 more
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The Lancet, 2005 Abstract Placebo, used here to mean an inert treatment given as if it was a real treatment, means lots of different things to different people. The structure of the article is that it begins by talking about the technical use of placebos in clinical trials, and the extent of the placebo response, then about the mechanism—“How does the ...
H J, McQuay, R A, Moore
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Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses
Brain Sciences, 2021 Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative ...
Michael Schaefer +2 more
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Scientific Reports, 2023 Placebo effects are known for numerous clinical symptoms. Until recently, deception of placebos was thought to be essential for placebo effects, but intriguing new studies suggest that even placebos without concealment (open-label placebos) may help ...
Michael Schaefer +2 more
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