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Roles of administration route, expectation, and belief in placebos in a randomized controlled trial with open-label placebos [PDF]

Scientific Reports
Recent reports challenge the view that placebos need to be given in deception. Numerous studies report remarkable effects when giving placebos honestly in an open way. However, the mechanisms of open-label placebos still remain to be cleared. For example,
Michael Schaefer, Carolin Liedtke, Sören Enge   +2 more
doaj   +2 more sources

Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos. [PDF]

PLoS ONE, 2012
BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Felicity L Bishop, Alison E M Adams, Ted J Kaptchuk, George T Lewith   +3 more
doaj   +11 more sources

Deceptive and open-label placebo effects in experimentally induced guilt: a randomized controlled trial in healthy subjects [PDF]

Scientific Reports, 2022
Placebos are known to yield significant effects in many conditions. We examined deceptive and open-label placebo effects on guilt, which is important for self-regulation and a symptom of mental disorders.
Dilan Sezer, Cosima Locher, Jens Gaab
doaj   +2 more sources

From catastrophizing to catalyzing: does pain catastrophizing modulate the beneficial impact of open-label placebos for chronic low back pain? A secondary analysis [PDF]

Frontiers in Psychology
Chronic back pain (CBP) is a global health problem with significant health and economic consequences. Traditional analgesics are often no better than placebo, highlighting the need for biopsychosocial approaches.
Elif Buse Caliskan, Elif Buse Caliskan, Katharina Schmidt, Andreas Hellmann, Tamás Spisák, Ulrike Bingel, Julian Kleine-Borgmann   +6 more
doaj   +2 more sources

Placebos without deception reduce self-report and neural measures of emotional distress

Nature Communications, 2020
There is controversy about whether placebos without deception cause real psychobiological benefits. Here, the authors show that the positive effects of placebos without deception are more than response bias by providing evidence they can reduce self ...
Darwin A Guevarra, Jason S Moser, Tor D Wager   +2 more
exaly   +2 more sources

Placebos in Healthcare: A Behavioral Study on How Treatment Responsiveness Affects Therapy Decisions in a Simulated Patient–Physician Interaction [PDF]

Clinics and Practice
Background and Purpose: Treatment choice during clinical practice is crucial to best help each patient. One of the physicians’ main goals is choosing a personalized effective treatment, but it also represents a challenging issue.
Alessandro Piedimonte, Valeria Volpino, Francesco Campaci, Francesca Borghesi, Giulia Guerra, Elisa Carlino   +5 more
doaj   +2 more sources

Magnitude of the Digital Placebo Effect and Its Moderators on Generalized Anxiety Symptoms: Systematic Review and Meta-Analysis

Journal of Medical Internet Research
Background Digital therapeutics (DTx) have attracted attention as the substitutes or add-ons to conventional pharmacotherapy. The number of clinical trials for DTx has increased recently, and one of the main targets for DTx is psychiatric disorders ...
Takashi Hosono, Rinka Tsutsumi, Yuki Niwa, Masuo Kondoh   +3 more
doaj   +2 more sources

Placebo Effects on the Enjoyment of Physical Activity and Performance among Kindergarten Children: A Randomized Controlled Trial [PDF]

European Journal of Investigation in Health, Psychology and Education
Studies with adults and school children have shown that placebos can enhance motivation and performance in physical activities. This study aimed to investigate whether similar effects are present in kindergarten-aged children. A total of 101 children (58
Marlies Stopper, Albert Wabnegger, Anne Schienle   +2 more
doaj   +2 more sources

A dose of doubt: a qualitative study on placebo regulations [PDF]

Frontiers in Medicine
IntroductionPlacebo use is common in primary care, yet ethical and legal concerns persist, and few qualitative studies have explored physicians’ views on placebo regulation.MethodsWe conducted semi-structured interviews with 10 primary care physicians ...
Mélina Richard, Mélina Richard, Manuela Ganz, Bernice S. Elger, Bernice S. Elger, Jens Gaab   +5 more
doaj   +2 more sources

Noble Humbug? Hard and soft laws on clinical placebo use [PDF]

Frontiers in Psychology
Despite the widespread historical and contemporary use of placebos in medicine, legal regulations addressing their administration remain limited in many countries.
Mélina Richard, Mélina Richard, Manuela Ganz, Lena Dominique Hornstein, Bohdan Stehlik, Mélanie Levy, Charlotte R. Blease, Marco Annoni, Bernice S. Elger, Jens Gaab   +9 more
doaj   +2 more sources