Placebos without deception reduce self-report and neural measures of emotional distress
Nature Communications, 2020 There is controversy about whether placebos without deception cause real psychobiological benefits. Here, the authors show that the positive effects of placebos without deception are more than response bias by providing evidence they can reduce self ...
Darwin A Guevarra +2 more
exaly +3 more sources
Effects of Open-Label Placebos on State Anxiety and Glucocorticoid Stress Responses
Brain Sciences, 2021 Stress belongs to the most frequent negative feelings people are confronted with in daily life. Strategies against acute stress include, e.g., relaxation techniques or medications, but it is also known that placebos can successfully reduce negative ...
Michael Schaefer +2 more
doaj +2 more sources
Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis. [PDF]
PLoS ONE, 2018 Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even ...
Michael Schaefer +2 more
doaj +2 more sources
BMC Psychiatry, 2020 Background The issue of unblinded outcome-assessors and patients has repeatedly been stressed as a flaw in allegedly double-blind antidepressant trials. Unblinding bias can for example result from a drug‘s marked side effects.
Lisa Holper, Michael P. Hengartner
doaj +2 more sources
Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos. [PDF]
PLoS ONE, 2012 BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Felicity L Bishop +3 more
doaj +7 more sources
From catastrophizing to catalyzing: does pain catastrophizing modulate the beneficial impact of open-label placebos for chronic low back pain? A secondary analysis [PDF]
Frontiers in PsychologyChronic back pain (CBP) is a global health problem with significant health and economic consequences. Traditional analgesics are often no better than placebo, highlighting the need for biopsychosocial approaches.
Elif Buse Caliskan +6 more
doaj +2 more sources
How often do general practitioners use placebos and non-specific interventions? Systematic review and meta-analysis of surveys. [PDF]
PLoS ONE, 2018 BACKGROUND:In a systematic review and meta-analysis we summarize the available evidence on how frequently general practitioners/family physicians (GPs) use pure placebos (e.g., placebo pills) and non-specific therapies (sometimes referred to as impure ...
Klaus Linde +6 more
doaj +2 more sources
Relieving pain using dose-extending placebos [PDF]
Pain, 2016 Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be ...
Colloca, Luana +2 more
core +2 more sources
A discursive exploration of public perspectives on placebos and their effects
Health Psychology Open, 2019 There is increasing evidence that placebos could be effective in clinical practice. However, knowledge of public perspectives on placebos is underdeveloped.
Doug I Hardman +4 more
doaj +2 more sources
Placebos in Healthcare: A Behavioral Study on How Treatment Responsiveness Affects Therapy Decisions in a Simulated Patient–Physician Interaction [PDF]
Clinics and PracticeBackground and Purpose: Treatment choice during clinical practice is crucial to best help each patient. One of the physicians’ main goals is choosing a personalized effective treatment, but it also represents a challenging issue.
Alessandro Piedimonte +5 more
doaj +2 more sources