Informed consent and placebo effects: a content analysis of information leaflets to identify what clinical trial participants are told about placebos. [PDF]
PLoS ONE, 2012 BackgroundPlacebo groups are used in randomised clinical trials (RCTs) to control for placebo effects, which can be large. Participants in trials can misunderstand written information particularly regarding technical aspects of trial design such as ...
Felicity L Bishop +3 more
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How often do general practitioners use placebos and non-specific interventions? Systematic review and meta-analysis of surveys. [PDF]
PLoS ONE, 2018 BACKGROUND:In a systematic review and meta-analysis we summarize the available evidence on how frequently general practitioners/family physicians (GPs) use pure placebos (e.g., placebo pills) and non-specific therapies (sometimes referred to as impure ...
Klaus Linde +6 more
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Scientific Reports, 2019 In recent years, placebos have evolved from a mean to control for ‘therapeutic chaff’ to something that has clinically relevant effects with biological underpinning and that is considered to have clinical as well as scientific potential.
Jens Gaab, Joe Kossowsky, Ulrike Ehlert
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Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. [PDF]
PLoS ONE, 2015 Clinical trials use placebos with the assumption that they are inert, thus all placebos are considered to be equal. Here we show that this assumption is wrong and that different placebo procedures are associated to different therapeutic rituals which, in
Fabrizio Benedetti, Sara Dogue
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Scientific Reports, 2019 Test anxiety is a condition in which people experience extreme distress and anxiety before and in test situations. It affects up to 40 percent of all students.
Michael Schaefer, Claudia Denke
exaly +2 more sources
From catastrophizing to catalyzing: does pain catastrophizing modulate the beneficial impact of open-label placebos for chronic low back pain? A secondary analysis [PDF]
Frontiers in PsychologyChronic back pain (CBP) is a global health problem with significant health and economic consequences. Traditional analgesics are often no better than placebo, highlighting the need for biopsychosocial approaches.
Elif Buse Caliskan +6 more
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Placebos in Healthcare: A Behavioral Study on How Treatment Responsiveness Affects Therapy Decisions in a Simulated Patient–Physician Interaction [PDF]
Clinics and PracticeBackground and Purpose: Treatment choice during clinical practice is crucial to best help each patient. One of the physicians’ main goals is choosing a personalized effective treatment, but it also represents a challenging issue.
Alessandro Piedimonte +5 more
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Journal of Medical Internet ResearchBackground Digital therapeutics (DTx) have attracted attention as the substitutes or add-ons to conventional pharmacotherapy. The number of clinical trials for DTx has increased recently, and one of the main targets for DTx is psychiatric disorders ...
Takashi Hosono +3 more
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Placebo Effects on the Enjoyment of Physical Activity and Performance among Kindergarten Children: A Randomized Controlled Trial [PDF]
European Journal of Investigation in Health, Psychology and EducationStudies with adults and school children have shown that placebos can enhance motivation and performance in physical activities. This study aimed to investigate whether similar effects are present in kindergarten-aged children. A total of 101 children (58
Marlies Stopper +2 more
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A dose of doubt: a qualitative study on placebo regulations [PDF]
Frontiers in MedicineIntroductionPlacebo use is common in primary care, yet ethical and legal concerns persist, and few qualitative studies have explored physicians’ views on placebo regulation.MethodsWe conducted semi-structured interviews with 10 primary care physicians ...
Mélina Richard +5 more
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