Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis. [PDF]
PLoS ONE, 2018 Several studies demonstrated that placebo treatment may have a significant impact on many different symptoms. While in the traditional view concealment of the placebo is essential, recent studies report intriguing evidence that placebos may work even ...
Michael Schaefer +2 more
doaj +2 more sources
BMC Psychiatry, 2020 Background The issue of unblinded outcome-assessors and patients has repeatedly been stressed as a flaw in allegedly double-blind antidepressant trials. Unblinding bias can for example result from a drug‘s marked side effects.
Lisa Holper, Michael P. Hengartner
doaj +2 more sources
Relieving pain using dose-extending placebos [PDF]
Pain, 2016 Placebos are often used by clinicians, usually deceptively and with little rationale or evidence of benefit, making their use ethically problematic. In contrast with their typical current use, a provocative line of research suggests that placebos can be ...
Colloca, Luana +2 more
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How often do general practitioners use placebos and non-specific interventions? Systematic review and meta-analysis of surveys. [PDF]
PLoS ONE, 2018 BACKGROUND:In a systematic review and meta-analysis we summarize the available evidence on how frequently general practitioners/family physicians (GPs) use pure placebos (e.g., placebo pills) and non-specific therapies (sometimes referred to as impure ...
Klaus Linde +6 more
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A discursive exploration of public perspectives on placebos and their effects
Health Psychology Open, 2019 There is increasing evidence that placebos could be effective in clinical practice. However, knowledge of public perspectives on placebos is underdeveloped.
Doug I Hardman +4 more
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Different Placebos, Different Mechanisms, Different Outcomes: Lessons for Clinical Trials. [PDF]
PLoS ONE, 2015 Clinical trials use placebos with the assumption that they are inert, thus all placebos are considered to be equal. Here we show that this assumption is wrong and that different placebo procedures are associated to different therapeutic rituals which, in
Fabrizio Benedetti, Sara Dogue
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Placebos as a Source of Agency: Evidence and Implications
Frontiers in Psychiatry, 2019 Bioethical discussions surrounding the use of placebos in clinical practice have long revolved around the moral permissibility of deceiving a patient if it is likely to benefit them.
Phoebe Friesen
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Are treatments more effective than placebos? A systematic review and meta-analysis.
PLoS ONE, 2013 BackgroundPlacebos are widely used in clinical practice in spite of ethical restrictions. Whether such use is justified depends in part on the relative benefit of placebos compared to 'active' treatments. A direct test for differences between placebo and
Jeremy Howick +8 more
doaj +2 more sources
Providing open-label placebos remotely—A randomized controlled trial in allergic rhinitis
PLoS ONE, 2021 Background Placebos can reduce physical symptoms even when provided with full honesty and disclosure. Yet, the precise mechanisms underlying the effects of “open-label placebos” (OLPs) have remained subject of debate.
T. Kube +3 more
semanticscholar +1 more source
‘Placebos’ and the logic of placebo comparison [PDF]
Biology & Philosophy, 2012 Robin Nunn has argued that we should stop using the terms ‘placebo’ and ‘placebo effect’. I argue in support of Nunn’s position by considering the logic of why we perform placebo comparisons. Like all comparisons, placebo comparison is just a case of comparing one thing with another, but it is a mistake, I argue, to think of placebo comparison as a ...
Turner, Andrew
core +6 more sources