Results 81 to 90 of about 732,852 (398)

Loss of maternal annexin A5 increases the likelihood of placental platelet thrombosis and foetal loss [PDF]

, 2012
Antiphospholipid syndrome is associated with an increased risk of thrombosis and pregnancy loss. Annexin A5 (Anxa5) is a candidate autoantigen. It is not known, however, whether endogenous Anxa5 prevents foetal loss during normal pregnancy.
Brachvogel, Bent, Hasegawa, Yoshihisa, Kawaminami, Mitsumori, Kurusu, Shiro, Laoharatchatathanin, Titaree, Mizushina, Tomona, Nishimura, Yasuhiro, Poschl, Ernst, Rieanrakwong, Duangjai, Terashima, Ryota, Ueki, Hiroshi, Yonezawa, Tomohiro   +11 more
core   +1 more source

New Insights into Atonic Postpartum Hemorrhage: Animal Model Construction Based on Placental Nanodelivery Systems

Advanced Healthcare Materials, EarlyView.
This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu, Ruiqi Wu, Hai Jiang, Lian Chen, Yingying Tian, Shuai Zeng, Tongmin Liu, Cheng Zhao, Huifeng Shi, Xiaolong Liang, Yangyu Zhao   +10 more
wiley   +1 more source

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes [PDF]

, 2015
Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition.
Aardema, Alves, Arsic, Asselin, Carluccio, Catov, Challis, Chen, Cheng, Cheng, Cheng, Cheng, Cherny, Chu, Crane, D.C. Wathes, D.R.E. Abayasekara, Flynn, Goncalves, Guillou, Herath, Jabbour, Karsch, Kim, Klein, Lamont, Lee, Leung, Lewis, Lunn, M. Elmes, Nielsen, Noble, Poyser, Reddy, Rimoldi, Robinson, S. Kirkup, Sharp, Smith, Smith, Thorburn, Villa, Wang, Wathes, Wendell, Whittle, Witkin, Z. Cheng, Zhang   +49 more
core   +2 more sources

Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs

Advanced Healthcare Materials, EarlyView.
Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner, Stefan Keim, Soheil Haddadzadegan, Odile Fernandez Romero, Katrin Zöller, Gabriel Stern, Ilaria Cesi, Krum Kafedjiiski, Andreas Bernkop‐Schnürch   +8 more
wiley   +1 more source

Modeling human trophoblast, the placental epithelium at the maternal fetal interface. [PDF]

, 2020
Appropriate human trophoblast lineage specification and differentiation is crucial for the establishment of normal placentation and maintenance of pregnancy. However, due to the lack of proper modeling systems, the molecular mechanisms of these processes
Bui, Tony, Horii, Mariko, Parast, Mana M, Touma, Ojeni   +3 more
core   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

The platelet-derived growth factor receptor alpha promoter-directed expression of cre recombinase in mouse placenta. [PDF]

, 2019
BackgroundNumerous pathologies of pregnancy originate from placental dysfunction. It is essential to understand the functions of key genes in the placenta in order to discern the etiology of placental pathologies.
Lee, Samuel, Natale, David Renato Christopher, Qiao, Liping, Shao, Jianhua, Wattez, Jean-Sebastien   +4 more
core   +1 more source

Bioprinted Constructs in the Regulatory Landscape: Current State and Future Perspectives

Advanced Materials, EarlyView.
Bioprinting has rapidly emerged as a transformative technology in biomedical research, offering unprecedented potential to replicate complex tissues. Despite its promise, clinical translation remains limited due to regulatory hurdles. This review explores global regulatory frameworks, comparing approaches in the EU, U.S., China, and Australia, and ...
Francesca Perin, Liliang Ouyang, Khoon S. Lim, Antonella Motta, Devid Maniglio, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Factores de riesgo de placenta previa en mujeres embarazadas en un hospital de República Dominicana

Ciencia y Salud, 2020
Introducción: la hemorragia obstétrica es una de las causas de morbilidad y mortalidad materna más común en todo el mundo. La placenta previa es un factor de riesgo importante para la hemorragia obstétrica.
Laura Manosalvas, Valerie Hernandez, Paola Peña, Leandro Tapia, Angiolina Camilo, Agustín Díaz-Rodríguez   +5 more
doaj   +1 more source

Decay resistance variability of European wood species thermally modified by industrial process [PDF]

, 2015
Thermal modification is now considered as a new ecofriendly industrial wood modification process improving mainly the material decay resistance and its dimensional stability.
Andersen, Anne Marie Nybo, Annesi Maesano, Isabella, Baï, Barros, Henrique, Basterrechea, Mikel, Correia, Sofia, Duijts, Liesbeth, Esplugues, Ana, Fantini, Maria Pia, Forastiere, Francesco, Galassi, Claudia, Gascon, Mireia, Gori, Davide, Inskip, Hazel, Larsen, Pernille S., Mommers, Monique, Penders, John, Petersen, Maria S., Pike, Katharine, Porta, Daniela, Richiardi, Lorenzo, Rusconi, Franca, Steuerwald, Ulrike, Sunyer, Jordi, Torrent, Maties, Voort, Agnes Sonnenschein van der, Vrijheid, Martine, Zugna, Daniela   +27 more
core   +3 more sources