Results 81 to 90 of about 167,631 (303)

Single‐cell and spatial transcriptomics: Discovery of human placental development and disease

FASEB BioAdvances
The human placenta is a vital organ, encompassing many distinct cell types, that maintains the growth and development of the fetus and is essential for substance exchange, defense, synthesis, and immunity.
Mi Tang, Liling Xiong, Jianghui Cai, Li Fan, Cheng Huang, Shimao Zhang, Ying Jin, Er‐dan Luo, ShaSha Xing, Xiao Yang   +9 more
doaj   +1 more source

DNA Methylation Signatures in Paired Placenta and Umbilical Cord Samples: Relationship with Maternal Pregestational Body Mass Index and Offspring Metabolic Outcomes

Biomedicines
An epigenomic approach was used to study the impact of maternal pregestational body mass index (BMI) on the placenta and umbilical cord methylomes and their potential effect on the offspring’s metabolic phenotype.
Ariadna Gómez-Vilarrubla, Berta Mas-Parés, Gemma Carreras-Badosa, Alexandra Bonmatí-Santané, Jose-Maria Martínez-Calcerrada, Maria Niubó-Pallàs, Francis de Zegher, Lourdes Ibáñez, Abel López-Bermejo, Judit Bassols   +9 more
doaj   +1 more source

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

Advanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan, Yelian Yan, Yalin Liang, Kanghua Zhong, Zhican Fu, Xiaobo Wang, Chao Liu, Tao Huang, Keliang Wu   +8 more
wiley   +1 more source

Updates on placental studies in bitches [PDF]

Ciência Rural
: The placenta, despite being a temporary organ, is essential for the development and survival of the conceptus. During pregnancy, it performs essential functions, such as nutrition, protection, circulation, excretion, and secretion.
Sarah Fernanda Salgado Tavares Farias, Lúcia Daniel Machado da Silva   +1 more
doaj   +1 more source

Maternal diet modulates placenta growth and gene expression in a mouse model of diabetic pregnancy. [PDF]

PLoS ONE, 2012
Unfavorable maternal diet during pregnancy can predispose the offspring to diseases later in life, such as hypertension, metabolic syndrome, and obesity. However, the molecular basis for this phenomenon of "developmental programming" is poorly understood.
Claudia Kappen, Claudia Kruger, Jacalyn MacGowan, J Michael Salbaum   +3 more
doaj   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source

Paternal Caffeine Exposure Programs Offspring Stress Vulnerability via Sperm Dlk1‐Dio3 Imprinting‐Directed Remodeling of a Novel Neural Circuit

Advanced Science, EarlyView.
The study elucidates that paternal preconception stress can drive offspring hyperresponsivity of the stress system via hypomethylation of a specific DNA region in sperm. This key link is confirmed in a cohort of prospective fathers: the epigenetic alteration is associated with elevated stress hormone levels.
Mengxi Lu, Gaole Dai, Sen Zhu, Shuai Zhang, Tingting Wang, Yuan Meng, Fang Yang, Xiaoyi Han, Hui Wang, Hao Kou, Dan Xu   +10 more
wiley   +1 more source

Giant chorioangioma of the complicated placenta with retroplacental hematoma. Presentation of a patient

Acta Médica del Centro, 2016
The abnormal proliferation of vessels derived from the placenta is known as chorioangioma, although it is the most common placental benign tumor not trophoblastic of the placenta occurs in a frequency as low as 1% of pregnancies.
Yarima Bravo Torres, Sandi Jiménez Puñales, Yoel Cardet Niebla   +2 more
doaj  

Placental Site Trophoblastic Tumor Acquires Immune Functions by Incorporating Host Maternal Genes

Advanced Science, EarlyView.
PSTT cells, through cell fusion with B cells, incorporate abundant non‐inherited maternal genes that are detectable by DNIMA. These hybrid cells acquire immunotherapy‐resistant genetic changes and increase the expression of B cell‐derived immune‐related molecules such as Ig, HLA, LILRB, SIGLEC10, and so on, creating an immunotolerant environment around
Kyosuke Kagami, Masanori Ono, Yasunari Mizumoto, Tatsuhito Kanda, Takashi Iizuka, Takiko Daikoku, Shin‐ichi Horike, Akira Hattori, Akihito Horie, Sachiko Minamiguchi, Tomoko Fujiwara, Kazuyoshi Hosomichi, Atsushi Tajima, Hirokazu Usui, Kaoru Abiko, Hiroshi Fujiwara   +15 more
wiley   +1 more source

Placental Morphology of Pregnant Iraqi Women with Rheumatic Heart Disease

Makara Journal of Health Research, 2016
Background: Placental morphology and cellular arrangement can be altered in maternal diseases. Rheumatic heart disease (RHD) is a chronic heart condition that can lead to death in pregnant women.
Anwar IS Al-Assa, Ragwa HI Al-Rubai, Imad M. Al-Ani, Salim R. Al-Ubeidie, Kawkab SN Al-Kaisy, Ghasak G. Faisal   +5 more
doaj   +1 more source