Results 61 to 70 of about 2,454,543 (303)

m6A‐Driven Pexophagy Triggers Placental Ferroptosis to Impair Fetal Growth Upon Environmental Stress

Advanced Science, EarlyView.
Prenatal environmental stress exposure promotes m6A modification to drive PEX2‐dependent pexophagy, thereby causing placental ferroptosis and FGR. ABSTRACT The role and underlying mechanisms of placental ferroptosis in fetal growth restriction (FGR) induced by environmental stress remain poorly understood.
Xin‐Xin Zhang, Ye‐Xin Luo, Cheng‐Fang Sun, Rui Pan, Yu‐Xi Wu, Zhi Yuan, Xin‐Run Wang, Xu‐Dong Zhang, Lan‐Lan Wu, Xiang‐Yu Yao, Zhan‐Dong Song, Wei Chang, Tian Wei, Pan‐Yuan Cai, Tian‐Ci Zhang, Yong‐Wei Xiong, De‐Xiang Xu, Hua Wang, Hua‐Long Zhu   +18 more
wiley   +1 more source

Upregulation of IL-15 in the placenta alters trophoblasts behavior contributing to gestational diabetes mellitus

Cell & Bioscience, 2021
Background Interleukin-15 (IL-15), a member of the ‘four α-helix bundle’ cytokine family, has been associated with many inflammatory and metabolic diseases.
Jiaqi Li, Yuan Li, Xuan Zhou, Lijie Wei, Jingyi Zhang, Shenglan Zhu, Huiting Zhang, Xuan Gao, Lali Mwamaka Sharifu, Shaoshuai Wang, Ling Xi, Ling Feng   +11 more
doaj   +1 more source

Moderate exercise attenuates lipopolysaccharide-induced inflammation and associated maternal and fetal morbidities in pregnant rats

, 2021
sem informação45102102Meeting of the International-Federation-of-Placenta-Associations (IFPA) - Placenta-Back to the Basicssem ...
Othman, Maha, Cotechini, Tiziana, Macdonald-Goodfellow, Shannyn K., Surita, Fernanda G., Graham, Charles H., Kasawara, Karina T., Tayade, Chandrakant, Pinto e Silva, Joao L., Ozolins, Terrence R. S.   +8 more
core   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Locus-specific DNA methylation prediction in cord blood and placenta

Epigenetics, 2019
DNA methylation is known to be responsive to prenatal exposures, which may be a part of the mechanism linking early developmental exposures to future chronic diseases. Many studies use blood to measure DNA methylation, yet we know that DNA methylation is
Baoshan Ma, Catherine Allard, Luigi Bouchard, Patrice Perron, Murray A. Mittleman, Marie-France Hivert, Liming Liang   +6 more
doaj   +1 more source

Avaliação do nicho molecular de células-tronco hematopoéticas e mesenquimais em placenta humana: caracterização estrutural e ultraestrutural [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento, Florianópolis, 2014.A placenta é um órgão essencial no desenvolvimento embrionário e fetal.
Gargioni, Rogério
core  

Modelling the placenta from the bottom up: digital phenotyping of human placenta histology [PDF]

Accurate placenta histopathology assessment is essential for immediate and lifelong clinical management of mother and newborn health. However, the placenta’s heterogeneity and high disease tolerance are challenging for robust, reproducible histological ...
Vanea, Claudia
core   +1 more source

The placenta in fetal growth restriction: What is going wrong?

, 2020
The placenta is essential for the efficient delivery of nutrients and oxygen from mother to fetus to maintain normal fetal growth. Dysfunctional placental development underpins many pregnancy complications, including fetal growth restriction (FGR) a ...
Oyston, Charlotte, Sun, Cherry, Chamley, Lawrence W, Groom, Katie M, James, Joanna L, Clark, Alys R   +5 more
core   +1 more source

Placental MRI: Development of an MRI compatible ex vivo system for whole placenta dual perfusion

, 2022
© 2020 Elsevier Ltd Purpose: Placental dysfunction plays a key role in diseases that affect the fetus in utero and after birth. Aiming to develop a platform for validating in vivo placental MRI and investigations into placental physiology, we designed ...
Turk, Esra Abaci, Grant, P Ellen, Luo, Jie, Roberts, Drucilla J, Stout, Jeffrey N, Ha, Christopher G, Rich, Karen, Wald, Lawerence L, Barth, William H, Rouhani, Shahin, Adalsteinsson, Elfar   +10 more
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source