Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]
, 2007 Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Aplin, JD +6 more
core +1 more source
Secretion of placental peptide hormones: functions and trafficking. [PDF]
Front Endocrinol (Lausanne)The placenta is a dynamic endocrine organ that plays a crucial role in fetal development by secreting a diverse array of peptide hormones that regulate maternal and fetal physiology.
Ahmadi SM, Perez ML, Guardia CM.
europepmc +2 more sources
HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia [PDF]
, 2017 Preeclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify dysregulated genes in maternal whole blood samples which may be ...
Akehurst, Christine +8 more
core +1 more source
Does Antenatal Maternal Psychological Distress Affect Placental Circulation in the Third Trimester?
PLoS ONE, 2013 Introduction Some types of antenatal maternal psychological distress may be associated with reduced fetal growth and birthweight. A stress-mediated reduction in placental blood flow has been suggested as a mechanism.
A. Helbig, A. Kaasen, U. Malt, G. Haugen
semanticscholar +1 more source
MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]
, 2016 PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet +6 more
core +2 more sources
A computational model of the fetal circulation to quantify blood redistribution in intrauterine growth restriction. [PDF]
PLoS Computational Biology, 2014 Intrauterine growth restriction (IUGR) due to placental insufficiency is associated with blood flow redistribution in order to maintain delivery of oxygenated blood to the brain.
Patricia Garcia-Canadilla +7 more
doaj +1 more source
Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]
, 1989 Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY +7 more
core +3 more sources
The effect of maternal iron deficiency on zinc and copper levels and on genes of zinc and copper metabolism during pregnancy in the rat [PDF]
, 2019 Fe deficiency is relatively common in pregnancy and has both short- and long-term consequences. However, little is known about the effect on the metabolism of other micronutrients.
Cottin, Sarah C. +5 more
core +3 more sources
ACS Sensors, 2023 Serving as the interface between fetal and maternal circulation, the placenta plays a critical role in fetal growth and development. Placental exosomes are small membrane-bound extracellular vesicles released by the placenta during pregnancy.
Cong Minh Nguyen +6 more
semanticscholar +1 more source
Bioengineering & Translational Medicine, 2023 Placental villi play a vital role in human fetal development, acting as the bridge of material exchange between the maternal and fetal. The abnormal morphology of placental villi is closely related to placental circulation disorder and pregnancy ...
Guangming Ni +8 more
doaj +1 more source