Results 51 to 60 of about 657,935 (241)

Causes and Consequences of the Dysregulated Maternal Renin-Angiotensin System in Preeclampsia

Frontiers in Endocrinology, 2019
A healthy pregnancy outcome depends on the activation of the renin-angiotensin-aldosterone system (RAAS) as a regulated, integrated response to the growing demands of the conceptus.
Eugenie R. Lumbers, Eugenie R. Lumbers, Eugenie R. Lumbers, Sarah J. Delforce, Sarah J. Delforce, Sarah J. Delforce, Anya L. Arthurs, Kirsty G. Pringle, Kirsty G. Pringle, Kirsty G. Pringle   +9 more
doaj   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source

The role of placental hormones and metabolites in modulating uterine circulation in physiological and pathological pregnancies

Frontiers in Endocrinology
The adaptation of the uterine circulation during pregnancy is fundamental to ensure an adequate supply of oxygen and nutrients to the fetus, and this process is largely orchestrated by placental hormones/metabolites.
Milena Esposito, Luana Paulesu, Maurizio Mandalà, Maurizio Mandalà   +3 more
doaj   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Cytokine patterns in very low birth weight infants under different cord clamping strategies: preliminary EXPLAIN trial data

BMC Pediatrics
Background Delayed umbilical cord clamping (DCC) improves survival and hematologic outcomes in preterm infants. Strategies that provide initial respiratory support before cord clamping may prolong intact placental circulation beyond standard time-based ...
Benjamin Kuehne, Mohamed Majjouti, Jochen Wilhelm, Sarina K. Butzer, Angela Kribs, Miguel A. Alejandre Alcazar, Esther Mahabir, André Oberthuer   +7 more
doaj   +1 more source

Development of the Human Placenta and Fetal Heart: Synergic or Independent?

Frontiers in Physiology, 2018
The placenta is the largest fetal organ, and toward the end of pregnancy the umbilical circulation receives at least 40% of the biventricular cardiac output.
Graham J. Burton, Eric Jauniaux
doaj   +1 more source

Features of the formation of pathogenetic changes of the placental complex on the background of intra-uteronomy infection

Journal of V. N. Karazin Kharkiv National University: Series Medicine, 2022
. One of the main complications during early embryogenesis and placentation is placental insufficiency. Under the influence of various factors, namely infectious factors, which, depending on the biological specificity, negatively affect the germ cells of
Alisa Hoshovska
doaj   +1 more source

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Expressão imunoistoquímica de diferenciação e crescimento celular em cardiomiócitos de neonatos Immunohistochemical expression of cell differentiation and growth in neonate cardiomyocytes

Arquivos Brasileiros de Cardiologia, 2012
FUNDAMENTO: As alterações cardíacas na fase de transição do coração fetal para a vida extrauterina vêm sendo exploradas por inúmeras pesquisas em animais, e os mecanismos celulares responsáveis por essas modificações ainda não estão bem documentado em ...
Tarcísio Fulgêncio Alves da Silva, Greyce Kelly de Souza, Mona Adalgisa Simões, Francisco Cesar Pabis, Lucia de Noronha   +4 more
doaj  

Activity of kallikrein-kinin system of blood and state of placental circulation at full-term pregnancy

Бюллетень сибирской медицины, 2012
The activity of kallikrein-kinin system of blood and the state of placental circulation at full-term physiological pregnancy have been studied.In 30 pregnant women aged 18—27 at 38th—40th weeks of pregnancy, the activity of  kallikrein-kinin system (KKS)
G. T. Kairov, V. S. Denisova, M. A. Medvedev   +2 more
doaj   +1 more source