Results 41 to 50 of about 194,763 (288)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Ultrasound and clinical-morphological evaluation of fetal-placental complex of pregnant women with intrauterine infection [PDF]

Гинекология, 2015
Analysis of ultrasound and clinical and morphological data of 52 cases complicated by placental insufficiency and the presence of intrauterine infection have performed.
S M Voevodin, T V Shemanaeva, A I Shchegolev   +2 more
doaj  

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

Reduced growth velocity across the third trimester is associated with placental insufficiency in fetuses born at a normal birthweight: a prospective cohort study

BMC Medicine, 2017
Background While being small-for-gestational-age due to placental insufficiency is a major risk factor for stillbirth, 50% of stillbirths occur in appropriate-for-gestational-age (AGA, > 10th centile) fetuses.
Teresa M. MacDonald, Lisa Hui, Stephen Tong, Alice J. Robinson, Kirsten M. Dane, Anna L. Middleton, Susan P. Walker   +6 more
doaj   +1 more source

Lack of placental neurosteroid alters cortical development and female somatosensory function

Frontiers in Endocrinology, 2022
Placental endocrine function is essential to fetal brain development. Placental hormones include neurosteroids such as allopregnanolone (ALLO), a regulator of neurodevelopmental processes via positive allosteric modulation of the GABAA receptor (GABAA-R).
Dana Bakalar, Jiaqi J. O’Reilly, Helene Lacaille, Jacquelyn Salzbank, Jacob Ellegood, Jason P. Lerch, Toru Sasaki, Yuka Imamura, Kazue Hashimoto-Torii, Claire-Marie Vacher, Anna A. Penn   +10 more
doaj   +1 more source

CHD8‐Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs

Advanced Science, EarlyView.
In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Yuanyuan Huang, Zhenhua Hu, Jiali Liao, Lijun Huang, Jinyu Liu, Chen Tu, Yuchen Li, Lulu Xie, Shilei Bi, Xiaobo Fang, Jingsi Chen, Lili Du, Wei Sun, Haibin Wang, Shuang Zhang, Dunjin Chen, Zhaowei Tu   +16 more
wiley   +1 more source

Novel use of proton magnetic resonance spectroscopy (1HMRS) to non-invasively assess placental metabolism.

PLoS ONE, 2012
BackgroundPlacental insufficiency is a major cause of antepartum stillbirth and fetal growth restriction (FGR). In affected pregnancies, delivery is expedited when the risks of ongoing pregnancy outweigh those of prematurity.
Fiona C Denison, Scott I Semple, Sarah J Stock, Jane Walker, Ian Marshall, Jane E Norman   +5 more
doaj   +1 more source

Schematic diagrams showing the mechanism of SGA and DSD in simple placental insufficiency and MIRAGE syndrome.

, 2018
SGA and DSD can be resulted from placental insufficiency (Left panel). In MIRAGE syndrome, cell-level growth restriction, which is a direct effect of a SAMD9 variant, cause additional negative effect on fetal growth and testicular development, giving ...
Masafumi Kon (5942606), Makoto Oshiro (5942600), Maki Fukami (106856), Naoko Amano (306489), Hirohito Shima (5942591), Ryuji Fukuzawa (323043), Yukichi Tanaka (259254), Maki Igarashi (431472), Tomonobu Hasegawa (306494), Mie Hayashi (5942594), Takashi Tachibana (5942597), Tomohiro Ishii (306487), Hidenori Haruna (5942603), Satoshi Narumi (306490)   +13 more
core   +1 more source

An Adenoviral‐Vectored Tp0326 Vaccine Elicits Robust Functional Antibodies to Prevent Treponema pallidum Dissemination in a Rabbit Model

Advanced Science, EarlyView.
Vaccination promotes cellular infiltration into primary lesions and effectively inhibits T. pallidum dissemination to distal organs. Notably, transfer of lesion tissue from immunized animals fails to establish infection in naive recipients, confirming specific protective immunity.
Yinbo Jiang, Xinyuan Li, Lixia Huang, Xiangcai Zhang, Wujian Ke   +4 more
wiley   +1 more source