Results 51 to 60 of about 182,272 (284)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Pregnancy‐associated venous insufficiency course with placental and systemic oxidative stress

, 2020
The development of lower extremity venous insufficiency (VI) during pregnancy has been associated with placental damage. VI is associated with increased oxidative stress in venous wall.
Melchor Álvarez‐Mon, Bravo, Coral, Natalio García‐Honduvilla, García-Honduvilla, Natalio, Coral Bravo, Julia Buján, Romero, Beatriz, Beatriz Romero, Martínez‐Vivero, Clara, Miguel A. Ortega, Buján, Julia, Martínez-Vivero, Clara, Álvarez‐Mon, Melchor, García‐Honduvilla, Natalio, Asúnsolo, Ángel, Bravo Arribas, Coral, León Luis, Juan Antonio, Ortega, Miguel A, Álvarez-Mon, Melchor, Juan De León‐Luis, Felipe Sainz, Ortega, Miguel Angel, Clara Martínez‐Vivero, Ángel Asúnsolo, De León-Luis, Juan, Sainz, Felipe   +25 more
core   +1 more source

Placental Insufficiency and Fetal Growth Restriction [PDF]

The Journal of Obstetrics and Gynecology of India, 2011
Fetal growth restriction is defined as a pathologic decrease in the rate of fetal growth. The most frequent etiology for late onset fetal growth restriction is uteroplacental dysfunction which is due to inadequate supply of nutrients and oxygen to support normal aerobic growth of the fetus.
Usha, Krishna, Sarita, Bhalerao
openaire   +2 more sources

In-vitro study of the effect of anti-hypertensive drugs on placental hormones and angiogenic proteins synthesis in pre-eclampsia [PDF]

, 2014
Antihypertensive drugs lower the maternal blood pressure in pre-eclampsia (PE) by direct or central vasodilatory mechanisms but little is known about the direct effects of these drugs on placental ...
Muttukrishna, S, Jauniaux, E, Gangooly, Subrata, Jauniaux, Eric, Gangooly, S, Shanthi Muttukrishna, Eric Jauniaux, Muttukrishna, Shanthi, Subrata Gangooly   +8 more
core   +2 more sources

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

THE ROLE OF CYTOKINES AND AGMATINE IN THE DEVELOPING PLACENTA WITH PHYSIOLOGICAL AND PREGNANCY COMPLICATED

Медицинский вестник Юга России, 2013
Purpose: To study the content of cytokines and agmatine in the development of the placenta in physiological and complicated gestation.Materials and Methods: 57 women, of which 34 women with physiological pregnancy and 23 women with placental ...
A. S. Degtyareva, I. I. Krukier, E. V. Narezhnaya, V. V. Avrutskaya, M. A. Levkovich, A. A. Nikashina   +5 more
doaj   +1 more source

Fetal immunodeficiency: A consequence of placental insufficiency

International Journal of Gynecology & Obstetrics, 1993
ABSTRACTObjective To study the effect of placental insufficiency on fetal lymphocyte subpopulations.Study design Cross sectional study of 19 growth retarded fetuses undergoing cordocentesis at 24 to 37 weeks gestation. Flow cytometry was used to enumerate fetal blood lymphocyte subpopulations.Results The mean T (CD3+), B (CD19+), T ...
Thilaganathan, B., Plachouras, N., Makrydimas, G., Nicolaides, K. H.   +3 more
openaire   +3 more sources

The importance of determining human placental lactogen in the third trimester of pregnancy [PDF]

Journal of Medical Biochemistry, 2009
Human placental lactogen (HPL) is a hormone produced by the placenta with a role in the regulation of fetoplacental growth. In this paper, the results of HPL determination in the third trimester of pregnancy are presented with the aim of testing the ...
Durković Jasmina, Mandić Bojana
doaj  

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source