Results 91 to 100 of about 403,052 (287)
Alaska mining and water quality [PDF]
, 1976 The Institute of Water Resources has sought financial assistance for some time in an attempt to initiate research relative to the impact of mining on water quality. Attempts were made as early as 1971 by Dr. Timothy Tilsworth and later by Dr.
Cook, Donald J. +2 more
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Las performances del riesgo y los límites de la sexualidad
Maguaré, 2015 Este texto examina las contribuciones del feminismo y de la teoría social contemporánea en torno a las articulaciones entre violencia, género y erotismo. El análisis bibliográ co busca re nar los instrumentos conceptuales que permitan aprehender los
Maria Filomena Gregori
doaj
Kemungkinan sebaran zirkon pada endapan placer di Pulau Kalimantan
Indonesian Journal on Geoscience, 2014 http://dx.doi.org/10.17014/ijog.vol2no2.20073Most alluvium with valued heavy minerals originated from regions of continental shelf, from which recycle process for stable minerals play an important role in transportation and final concentration formation ...
Danny Zulkifli Herman
doaj +1 more source
Onanismo, el funesto placer solitario [PDF]
, 2009 La palabra “onanismo” proviene de un error en la percepción del pecado de codicia de Onán, el cual fue tomado como pecado carnal. En la antigüedad, el placer fue visto como un signo de salud física y moral hasta que la medicina griega consideró que el ...
Iglesias Benavides, José Luis
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Estudios de Teoría Literaria, 2018 Reseña bibliográfica del libro Gusto de Giorgio Agamben, Buenos Aires, Adriana Hidalgo, 2016, 70 pp.
Rosalía Baltar
doaj
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
La lectura: juego, descubrimiento, placer [PDF]
, 2001 [Resumen] La lectura -que en su etapa de aprendizaje no debe separarse de la escritura- ha de ser un juego para el niño que empieza a descifrar ese "mundo de jeroglíficos", en palabras de EUmbral.
Pérez, Miguel José
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source