Results 31 to 40 of about 2,485 (179)
A low diversity of ANTP class homeobox genes in Placozoa
Evolution & Development, 2006 SUMMARYHomeobox genes of the ANTP and PRD classes play important roles in body patterning of metazoans, and a large diversity of these genes have been described in bilaterian animals and cnidarians.Trichoplax adhaerens(Phylum Placozoa) is a small multicellular marine animal with one of the simplest body organizations of all metazoans, showing no ...
Monteiro, A +3 more
openaire +3 more sources
Evolution of glial cells: a non-bilaterian perspective [PDF]
Neural DevelopmentNervous systems of bilaterian animals generally consist of two cell types: neurons and glial cells. Despite accumulating data about the many important functions glial cells serve in bilaterian nervous systems, the evolutionary origin of this abundant ...
Larisa Sheloukhova, Hiroshi Watanabe
doaj +2 more sources
Communications Biology, 2023 ASIC channels are bilaterian proton-gated sodium channels belonging to the large and functionally-diverse Deg/ENaC family that also includes peptide- and mechanically-gated channels.
Wassim Elkhatib +7 more
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Early Animal Origin of BACE1 APP/Aβ Proteolytic Function [PDF]
BiologyAlzheimer’s disease is characterized, in part, by the accumulation of β-amyloid (Aβ) in the brain. Aβ is produced via the proteolysis of APP by BACE1 and γ-secretase.
James A. Langeland +6 more
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Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor [PDF]
Communications BiologyEpsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh +9 more
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Transposon-derived transcription factors across metazoans
Frontiers in Cell and Developmental Biology, 2023 Transposable elements (TE) could serve as sources of new transcription factors (TFs) in plants and some other model species, but such evidence is lacking for most animal lineages. Here, we discovered multiple independent co-options of TEs to generate 788
Krishanu Mukherjee +2 more
doaj +1 more source
The ancestral architecture of the immune system in simplest animals [PDF]
Frontiers in ImmunologyDaria Y. Romanova +2 more
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Deep RNA sequencing reveals the smallest known mitochondrial micro exon in animals: The placozoan cox1 single base pair exon. [PDF]
PLoS ONE, 2017 The phylum Placozoa holds a key position for our understanding of the evolution of mitochondrial genomes in Metazoa. Placozoans possess large mitochondrial genomes which harbor several remarkable characteristics such as a fragmented cox1 gene and trans ...
Hans-Jürgen Osigus +2 more
doaj +1 more source
Alternative neural systems: What is a neuron? (Ctenophores, sponges and placozoans)
Frontiers in Cell and Developmental Biology, 2022 How to make a neuron, a synapse, and a neural circuit? Is there only one ‘design’ for a neural architecture with a universally shared genomic blueprint across species?
Leonid L. Moroz +2 more
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Protein Science, Volume 32, Issue 7, July 2023., 2023 Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič +5 more
wiley +1 more source