Results 1 to 10 of about 131 (116)

A clustered set of three Sp-family genes is ancestral in the Metazoa: evidence from sequence analysis, protein domain structure, developmental expression patterns and chromosomal location

BMC Evolutionary Biology, 2010
Background The Sp-family of transcription factors are evolutionarily conserved zinc finger proteins present in many animal species. The orthology of the Sp genes in different animals is unclear and their evolutionary history is therefore controversially ...
Wimmer Ernst A, Prpic Nikola-Michael, Schaeper Nina D   +2 more
doaj   +1 more source

Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms

Nature Communications
Nucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen, Sergio G. Bartual, Huijie Yuan, Olawale G. Raimi, Andrii Gorelik, Andrew T. Ferenbach, Kristian Lytje, Jan Skov Pedersen, Taner Drace, Thomas Boesen, Daan M. F. van Aalten   +10 more
doaj   +1 more source

A conserved cluster of three PRD-class homeobox genes (homeobrain, rx and orthopedia) in the Cnidaria and Protostomia

EvoDevo, 2010
Background Homeobox genes are a superclass of transcription factors with diverse developmental regulatory functions, which are found in plants, fungi and animals.
Mazza Maureen E, Pang Kevin, Reitzel Adam M, Martindale Mark Q, Finnerty John R   +4 more
doaj   +1 more source

Apicortin defines the Plasmodium apical conoid body but is dispensable for the parasite life cycle

Life Science Alliance
Apicortin shapes the Plasmodium cytoskeleton at the apical end without impacting transmission. Apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii possess unique tubulin-based structures, including subpellicular microtubules and apical ...
Mohammad Zeeshan, Akancha Mishra, Sarah L Pashley, Robert Markus, Declan Brady, Anthony A Holder, Carolyn Moores, Rita Tewari   +7 more
doaj   +1 more source

Expression and phylogenetic analysis of the zic gene family in the evolution and development of metazoans

EvoDevo, 2010
Background zic genes are members of the gli/glis/nkl/zic super-family of C2H2 zinc finger (ZF) transcription factors. Homologs of the zic family have been implicated in patterning neural and mesodermal tissues in bilaterians.
Layden Michael J, Meyer Néva P, Pang Kevin, Seaver Elaine C, Martindale Mark Q   +4 more
doaj   +1 more source

Genomic organization of eukaryotic tRNAs

BMC Genomics, 2010
Background Surprisingly little is known about the organization and distribution of tRNA genes and tRNA-related sequences on a genome-wide scale. While tRNA gene complements are usually reported in passing as part of genome annotation efforts, and ...
Prohaska Sonja J, Engelhardt Jan, Kirsten Toralf, Attolini Camille, Bermudez-Santana Clara, Steigele Stephan, Stadler Peter F   +6 more
doaj   +1 more source

apex Mk.2/Mk.3: Secure Live Transmission of the First Flight of Trichoplax adhaerens in Space Based on Components Off-the-Shelf

Eng
After the successful flight of the first Advanced Processors, Encryption, and Security Experiment (apex) Commercial Off-the-Shelf (COTS) On-Board Computer (OBC) during the Propulsion Technologies and Components of Launcher Stages (ATEK)/Material Physics ...
Nico Maas, Jean-Pierre de Vera, Moritz Jonathan Schmidt, Pia Reimann, Jason G. Randall, Sebastian Feles, Ruth Hemmersbach, Bernd Schierwater, Jens Hauslage   +8 more
doaj   +1 more source

The evolutionary diversification of LSF and Grainyhead transcription factors preceded the radiation of basal animal lineages

BMC Evolutionary Biology, 2010
Background The transcription factors of the LSF/Grainyhead (GRH) family are characterized by the possession of a distinctive DNA-binding domain that bears no clear relationship to other known DNA-binding domains, with the possible exception of the p53 ...
Kaufman Les, Martindale Mark Q, Dubuc Timothy Q, Hansen Ulla, Traylor-Knowles Nikki, Finnerty John R   +5 more
doaj   +1 more source

Correction: Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens.

PLoS Biology
[This corrects the article DOI: 10.1371/journal.pbio.3001471.].
Angelo Fortunato, Alexis Fleming, Athena Aktipis, Carlo C Maley   +3 more
doaj   +1 more source

Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor

Communications Biology
Epsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh, Boris S. Zhorov, Luis A. Yanez-Guerra, Alessandra Aleotti, Chloe C. Koens, C. Defne Yanartas, Yunqi Song, Federico Javier Miguez Cabello, Derek Bowie, Adriano Senatore   +9 more
doaj   +1 more source