Results 31 to 40 of about 2,460 (178)
Proteins: Structure, Function, and Bioinformatics, Volume 91, Issue 11, Page 1510-1524, November 2023., 2023 Abstract The hypoxia‐inducible factor (HIF) prolyl‐hydroxylases (human PHD1‐3) catalyze prolyl hydroxylation in oxygen‐dependent degradation (ODD) domains of HIFα isoforms, modifications that signal for HIFα proteasomal degradation in an oxygen‐dependent manner. PHD inhibitors are used for treatment of anemia in kidney disease. Increased erythropoietin
William D. Figg Jr. +6 more
wiley +1 more source
Defining bone fide effectors of RAS GTPases
BioEssays, Volume 45, Issue 9, September 2023., 2023 RAS GTPases transmit extracellular signals to multiple intracellular signalling pathways through direct interaction with effector proteins. These proteins typically employ RAS‐binding RBD domains to complex with activated GTPases, but the specificity of these interactions remains poorly explored and there remain few data describing the mechanistic ...
Matthew J. Smith
wiley +1 more source
Protein Science, Volume 32, Issue 7, July 2023., 2023 Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič +5 more
wiley +1 more source
The evolution of the four subunits of voltage-gated calcium channels : ancient roots, increasing complexity, and multiple losses [PDF]
, 2014 © The Author(s), 2014. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Genome Biology and Evolution 6 (2014): 2210-2217, doi:10.1093/gbe/evu177.The alpha subunits of voltage-
Moran, Yehu, Zakon, Harold H.
core +3 more sources
The Journal of Physiology, Volume 601, Issue 9, Page 1625-1653, 1 May 2023., 2023 Abstract figure legend Polar view of a phylogram of representative members of the DEG/ENaC superfamily, coloured according to phylum (Annelida, yellow; Arthropoda, light green; Chordata, dark green; Cnidaria, blue; Mollusca, dark purple; Nematoda, magenta; Placozoa, red). Construction of the phylogram is described in Fig. 1.
Eva Kaulich +3 more
wiley +1 more source
Methods in Ecology and Evolution, Volume 13, Issue 9, Page 1885-1898, September 2022., 2022 Abstract Cancer is an understudied but important process in wildlife that is predicted to have a significant effect on the evolution of metazoan species due to negative effects on host fitness. However, gaining understanding of the impact of cancer on species and ecosystems is currently relatively slow as the development of both animal models in which ...
Antoine M. Dujon +7 more
wiley +1 more source
Tropical Medicine and Infectious Disease, 2021 In 2009, apicortin was identified in silico as a characteristic protein of apicomplexans that also occurs in the placozoa, Trichoplax adhaerens. Since then, it has been found that apicortin also occurs in free-living cousins of apicomplexans (chromerids)
Ferenc Orosz
doaj +1 more source
Evolution of factors shaping the endoplasmic reticulum
Traffic, Volume 23, Issue 9, Page 462-473, September 2022., 2022 More than 15 proteins have a role in shaping the endoplasmic reticulum (ER) but studies on the evolution of these factors are lacking. Now, a molecular evolutionary analysis indicates that reticulons, REEPs, atlastin, spastin, lunapark, TMEM33, STIM1 and VAPs likely evolved as early as the last eukaryotic common ancestor (LECA).
Aspasia Kontou +4 more
wiley +1 more source
Insights into the evolution of digestive systems from studies of Trichoplax adhaerens [PDF]
Cell and Tissue Research, 2019 Trichoplax, a member of the phylum Placozoa, is a tiny ciliated marine animal that glides on surfaces feeding on algae and cyanobacteria. It stands out from other animals in that it lacks an internal digestive system and, instead, digests food trapped under its lower surface.
Carolyn L. Smith, Tatiana D. Mayorova
openaire +2 more sources
The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge
BioEssays, Volume 43, Issue 10, October 2021., 2021 Placozoans are the simplest and maybe the first branching metazoans. Their simple body plan and their small genome with a complex genetic tool kit make them important model systems. Substantial progress has been made in many areas, but many exciting questions on placozoan biology are still waiting to be addressed.
Bernd Schierwater +10 more
wiley +1 more source