Results 41 to 50 of about 1,558 (165)

Evolution of affinity between p53 transactivation domain and MDM2 across the animal kingdom demonstrates high plasticity of motif‐mediated interactions

Protein Science, Volume 32, Issue 7, July 2023., 2023
Abstract The interaction between the transcription factor p53 and the ubiquitin ligase MDM2 results in the degradation of p53 and is well‐studied in cancer biology and drug development. Available sequence data suggest that both p53 and MDM2‐family proteins are present across the animal kingdom.
Filip Mihalič, Emma Åberg, Pouria Farkhondehkish, Niels Theys, Eva Andersson, Per Jemth   +5 more
wiley   +1 more source

Physiological insight into the conserved properties of Caenorhabditis elegans acid‐sensing degenerin/epithelial sodium channels

The Journal of Physiology, Volume 601, Issue 9, Page 1625-1653, 1 May 2023., 2023
Abstract figure legend Polar view of a phylogram of representative members of the DEG/ENaC superfamily, coloured according to phylum (Annelida, yellow; Arthropoda, light green; Chordata, dark green; Cnidaria, blue; Mollusca, dark purple; Nematoda, magenta; Placozoa, red). Construction of the phylogram is described in Fig. 1.
Eva Kaulich, Patrick T. N. McCubbin, William R. Schafer, Denise S. Walker   +3 more
wiley   +1 more source

A review of the methods used to induce cancer in invertebrates to study its effects on the evolution of species and ecosystem functioning

Methods in Ecology and Evolution, Volume 13, Issue 9, Page 1885-1898, September 2022., 2022
Abstract Cancer is an understudied but important process in wildlife that is predicted to have a significant effect on the evolution of metazoan species due to negative effects on host fitness. However, gaining understanding of the impact of cancer on species and ecosystems is currently relatively slow as the development of both animal models in which ...
Antoine M. Dujon, Justine Boutry, Sophie Tissot, Jordan Meliani, Lena Guimard, Océane Rieu, Beata Ujvari, Frédéric Thomas   +7 more
wiley   +1 more source

Apicortin, a Constituent of Apicomplexan Conoid/Apical Complex and Its Tentative Role in Pathogen—Host Interaction

Tropical Medicine and Infectious Disease, 2021
In 2009, apicortin was identified in silico as a characteristic protein of apicomplexans that also occurs in the placozoa, Trichoplax adhaerens. Since then, it has been found that apicortin also occurs in free-living cousins of apicomplexans (chromerids)
Ferenc Orosz
doaj   +1 more source

Evolution of factors shaping the endoplasmic reticulum

Traffic, Volume 23, Issue 9, Page 462-473, September 2022., 2022
More than 15 proteins have a role in shaping the endoplasmic reticulum (ER) but studies on the evolution of these factors are lacking. Now, a molecular evolutionary analysis indicates that reticulons, REEPs, atlastin, spastin, lunapark, TMEM33, STIM1 and VAPs likely evolved as early as the last eukaryotic common ancestor (LECA).
Aspasia Kontou, Emily K. Herman, Mark C. Field, Joel B. Dacks, V. Lila Koumandou   +4 more
wiley   +1 more source

Insights into the evolution of digestive systems from studies of Trichoplax adhaerens [PDF]

Cell and Tissue Research, 2019
Trichoplax, a member of the phylum Placozoa, is a tiny ciliated marine animal that glides on surfaces feeding on algae and cyanobacteria. It stands out from other animals in that it lacks an internal digestive system and, instead, digests food trapped under its lower surface.
Carolyn L. Smith, Tatiana D. Mayorova
openaire   +2 more sources

The enigmatic Placozoa part 1: Exploring evolutionary controversies and poor ecological knowledge

BioEssays, Volume 43, Issue 10, October 2021., 2021
Placozoans are the simplest and maybe the first branching metazoans. Their simple body plan and their small genome with a complex genetic tool kit make them important model systems. Substantial progress has been made in many areas, but many exciting questions on placozoan biology are still waiting to be addressed.
Bernd Schierwater, Hans‐Jürgen Osigus, Tjard Bergmann, Neil W. Blackstone, Heike Hadrys, Jens Hauslage, Patrick O. Humbert, Kai Kamm, Marc Kvansakul, Kathrin Wysocki, Rob DeSalle   +10 more
wiley   +1 more source

The enigmatic Placozoa part 2: Exploring evolutionary controversies and promising questions on earth and in space

BioEssays, Volume 43, Issue 10, October 2021., 2021
Placozoans are a versatile model system in many areas of basic and applied research. The genetics of placozoans are well known and placozoans harbor a lot of potential for adapting latest molecular techniques for in vivo manipulation. Not surprising, placozoans have recently been introduced as a new model system also for gravitational biology and ...
Bernd Schierwater, Hans‐Jürgen Osigus, Tjard Bergmann, Neil W. Blackstone, Heike Hadrys, Jens Hauslage, Patrick O. Humbert, Kai Kamm, Marc Kvansakul, Kathrin Wysocki, Rob DeSalle   +10 more
wiley   +1 more source

Placozoan fiber cells: mediators of innate immunity and participants in wound healing

Scientific Reports, 2021
Placozoa is a phylum of non-bilaterian marine animals. These small, flat organisms adhere to the substrate via their densely ciliated ventral epithelium, which mediates mucociliary locomotion and nutrient uptake.
Tatiana D. Mayorova, Katherine Hammar, Jae H. Jung, Maria A. Aronova, Guofeng Zhang, Christine A. Winters, Thomas S. Reese, Carolyn L. Smith   +7 more
doaj   +1 more source

The cell cycle and differentiation as integrated processes: Cyclins and CDKs reciprocally regulate Sox and Notch to balance stem cell maintenance

BioEssays, Volume 43, Issue 7, July 2021., 2021
Development and maintenance of organs requires context‐specific regulation of stem cell activities. We hypothesize that these are dependent upon reciprocal interactions between the cell‐cycle machinery and regulators of stem cell differentiation. To support this, we discuss the mechanistic links between these processes, as well as their parallel ...
Jonas Muhr, Daniel W. Hagey
wiley   +1 more source