The origin and evolution of G protein-coupled receptor kinases. [PDF]
PLoS ONE, 2012 G protein-coupled receptor (GPCR) kinases (GRKs) play key role in homologous desensitization of GPCRs. GRKs phosphorylate activated receptors, promoting high affinity binding of arrestins, which precludes G protein coupling.
Arcady Mushegian +2 more
doaj +1 more source
Animal HECT ubiquitin ligases: evolution and functional implications [PDF]
, 2010 12 pages, 6 figures, 1 table, 3 additional files.[Background] HECT ubiquitin ligases (HECT E3s) are key components of the eukaryotic ubiquitin-proteasome system and are involved in the genesis of several human diseases.
Ignacio Marín
core +2 more sources
Global diversity of the Placozoa.
PLoS ONE, 2013 The enigmatic animal phylum Placozoa holds a key position in the metazoan Tree of Life. A simple bauplan makes it appear to be the most basal metazoan known and genetic evidence also points to a position close to the last common metazoan ancestor ...
Michael Eitel +3 more
doaj +1 more source
Mitochondrial genome of Trichoplax adhaerens supports placozoa as the basal lower metazoan phylum. [PDF]
Proc Natl Acad Sci U S A, 2006 Mitochondrial genomes of multicellular animals are typically 15- to 24-kb circular molecules that encode a nearly identical set of 12–14 proteins for oxidative phosphorylation and 24–25 structural RNAs (16S rRNA, 12S rRNA, and tRNAs). These genomes lack significant intragenic spacers and are generally without introns.
Dellaporta SL +6 more
europepmc +4 more sources
The evolution of the dystroglycan complex, a major mediator of muscle integrity [PDF]
, 2015 Basement membrane (BM) extracellular matrices are crucial for the coordination of different tissue layers. A matrix adhesion receptor that is important for BM function and stability in many mammalian tissues is the dystroglycan (DG) complex.
Adams, Josephine C, Brancaccio, Andrea
core +3 more sources
The origin of the Hox/ParaHox genes, the Ghost Locus hypothesis and the complexity of the first animal [PDF]
, 2015 A key aim in evolutionary biology is to deduce ancestral states in order to better understand the evolutionary origins of clades of interest and the diversification process(es) that have elaborated them.
Ferrier, David E. K.
core +1 more source
DNA Content and Fragmentation of the Egg Nucleus of Trichoplax adhaerens
Zeitschrift für Naturforschung C, 1981 Abstract Under culture conditions the egg nucleus of Trichoplax adhaerens reaches an unusually high and variable DNA content. Before the "fertilization membrane" is formed, the nucleus undergoes fragmentation. It is assumed that culture conditions differ from natural conditions by preventing the switch-over from the S-phase to the G 2 ...
A. Ruthmann, K. G. Grell, G. Benwitz
openaire +1 more source
Distinct expression patterns of the two T-box homologues Brachyury and Tbx2/3 in the placozoan Trichoplax adhaerens [PDF]
, 2018 Trichoplax adhaerens is the only species known from the phylum Placozoa with one of the simplest metazoan body plans. In the small disc-like organism an upper and a lower epithelium can be distinguished with a less compact third cell layer in between ...
Martinelli, Cosimo, Spring, Jürg
core
Beyond the Secretory Pathway: New Insights Into Protein Release
Traffic, Volume 26, Issue 10-12, October/December 2025.While proteins bearing N‐terminal signal or leader sequences are secreted via the ER‐Golgi‐plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequence can be secreted via poorly defined mechanisms termed Unconventional Protein Secretion (UcPS).
Ruey‐Hwa Chen +34 more
wiley +1 more source
Identification of 526 conserved metazoan genetic innovations exposes a new role for cofactor E-like in neuronal microtubule homeostasis. [PDF]
PLoS Genetics, 2013 The evolution of metazoans from their choanoflagellate-like unicellular ancestor coincided with the acquisition of novel biological functions to support a multicellular lifestyle, and eventually, the unique cellular and physiological demands of ...
Melissa Y Frédéric +11 more
doaj +1 more source