Results 61 to 70 of about 2,216 (134)
Invertebrate Bile Acid‐Sensitive Ion Channels and Their Emergence in Bilateria
The FASEB Journal, Volume 39, Issue 8, 30 April 2025.This graphical abstract presents the evolutionary distribution and functional characteristics of bile acid‐sensing ion channels (BASICs) across bilaterians. A phylogenetic tree illustrates the presence of BASICs in diverse groups, extending beyond previously established mammalian findings.
Josep Martí‐Solans +4 more
wiley +1 more source
Domain‐Shuffling in the Evolution of Cyclostomes and Gnathostomes
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, Volume 344, Issue 2, Page 59-79, March 2025.We addressed the potential roles of domain‐shuffling origin genes (DSO‐Gs) in the evolution of early vertebrates. Through comparative genome analysis of 22 metazoans, including four cyclostomes, we identified DSO‐Gs before and after the divergence of cyclostomes and gnathostomes, and suggest domain shuffling as a key mechanism in vertebrate early ...
Hirofumi Kariyayama +3 more
wiley +1 more source
Evolution of the Cdk4/6–Cdkn2 system in invertebrates
Genes to Cells, Volume 29, Issue 11, Page 1037-1051, November 2024.Hypothesis on the evolution of the Cdkn2 locus. (a) Loss of Cdkn2 occurred multiple times. (b) Evolution of microsynteny at the Cdkn2 locus. Cdkn2e is a hypothetical transient gene. Abstract The cell cycle is driven by cyclin‐dependent kinases (Cdks). The decision whether the cell cycle proceeds is made during G1 phase, when Cdk4/6 functions.
Shiori Yuki +5 more
wiley +1 more source
FEBS Letters, Volume 598, Issue 15, Page 1811-1838, August 2024.This Review presents the main advances in the study of PTP1B since it was first isolated, and recent contextual information related to this protein. Furthermore, we provide an overview of the role of PTP1B in diabetes and obesity, and the challenges of developing selective, effective, potent, bioavailable, and cell‐permeable compounds that can inhibit ...
Andrea Coronell‐Tovar +7 more
wiley +1 more source
Molecular mechanisms of perilipin protein function in lipid droplet metabolism
FEBS Letters, Volume 598, Issue 10, Page 1170-1198, May 2024.Lipid droplets (LDs) are important for the storage of energy and lipid components. The perilipin family in mammals includes five proteins (PLIN1 to PLIN5), all of which are abundant on the surface of LDs in different tissues and play a role in LD stability and degradation by lipases.
Elena Griseti +7 more
wiley +1 more source
Beauty in the beast – Placozoan biodiversity explored through molluscan predator genomics
Ecology and Evolution, Volume 14, Issue 4, April 2024.Previous assumptions about the primary habitat of Placozoa are challenged, and their broader diversity beyond disc‐shaped grazers in coastal waters is revealed. The discovery of placozoan‐predatory sea slugs prompts consideration of a new ecological niche: seafloor sediment interstices.
Michael Eitel +3 more
wiley +1 more source
Proteoglycans in mechanobiology of tissues and organs: Normal functions and mechanopathology
Proteoglycan Research, Volume 2, Issue 2, April-June 2024.Abstract Proteoglycans (PGs) are a diverse class of glycoconjugates that serve critical functions in normal mechanobiology and mechanopathology. Both the protein cores and attached glycosaminoglycan (GAG) chains function in mechanically sensitive processes, and loss of either can contribute to development of pathological conditions. PGs function as key
Mary C. Farach‐Carson +2 more
wiley +1 more source
Importance of fatty acid binding proteins in cellular function and organismal metabolism
Journal of Cellular and Molecular Medicine, Volume 28, Issue 5, March 2024.Abstract Fatty acid binding proteins (Fabps) are small soluble proteins that are abundant in the cytosol. These proteins are known to bind a myriad of small hydrophobic molecules and have been postulated to serve a variety of roles, yet their precise functions have remained an enigma over half a century of study.
Luis B. Agellon
wiley +1 more source
Evolution of selenoproteins in the metazoan
BMC Genomics, 2012 Background The selenocysteine (Sec) containing proteins, selenoproteins, are an important group of proteins present throughout all 3 kingdoms of life.
Jiang Liang, Ni Jiazuan, Liu Qiong
doaj +1 more source
Emergence, development and diversification of the TGF-
BMC Evolutionary Biology, 2009 Background The question of how genomic processes, such as gene duplication, give rise to co-ordinated organismal properties, such as emergence of new body plans, organs and lifestyles, is of importance in developmental and evolutionary biology.
Moustakas Aristidis +5 more
doaj +1 more source