The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System* [PDF]
Journal of Biological Chemistry, 2015 Protein O-GlcNAcylation is a reversible post-translational signaling modification of nucleocytoplasmic proteins that is essential for embryonic development in bilateria.
Henk van den Toorn +2 more
exaly +5 more sources
The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens [PDF]
EMBO Reports, 2011 The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate
Mathew L Coleman +2 more
exaly +3 more sources
Differentiation of Crystal Cells, Gravity-Sensing Cells in the Placozoan Trichoplax adhaerens
Journal of Marine Science and Engineering, 2021 Trichoplax adhaerens are simple animals with no nervous system, muscles or body axis. Nevertheless, Trichoplax demonstrate complex behaviors, including responses to the direction of the gravity vector.
Tatiana D. Mayorova
doaj +2 more sources
Novel Cell Types, Neurosecretory Cells, and Body Plan of the Early-Diverging Metazoan Trichoplax adhaerens [PDF]
Current Biology, 2014 SummaryBackgroundTrichoplax adhaerens is the best-known member of the phylum Placozoa, one of the earliest-diverging metazoan phyla. It is a small disk-shaped animal that glides on surfaces in warm oceans to feed on algae.
Carolyn L Smith +2 more
exaly +4 more sources
Coordinated cellular behavior regulated by epinephrine neurotransmitters in the nerveless placozoa [PDF]
Nature CommunicationsUnderstanding how cells communicated before the evolution of nervous systems in early metazoans is key to unraveling the origins of multicellular life.
Minjun Jin +7 more
doaj +2 more sources
Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms [PDF]
Nature CommunicationsNucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen +10 more
doaj +3 more sources
Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor [PDF]
Communications BiologyEpsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh +9 more
doaj +2 more sources
Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior. [PDF]
PLoS ONEPlacozoa are millimeter-sized, flat, irregularly shaped ciliated animals that crawl on surfaces in warm oceans feeding on biofilms, which they digest externally. They stand out from other animals due to their simple body plans.
Tatiana D Mayorova +5 more
doaj +2 more sources
Growth produces coordination trade-offs in Trichoplax adhaerens, an animal lacking a central nervous system. [PDF]
Proc Natl Acad Sci U S A, 2023 International audienceHow collectives remain coordinated as they grow in size is a fundamental challenge affecting systems ranging from biofilms to governments.
Davidescu MR +3 more
europepmc +2 more sources
The cobalamin processing enzyme of Trichoplax adhaerens. [PDF]
J Biol ChemCobalamin (Cbl) is an essential cofactor for methionine synthase and methylmalonyl-CoA mutase, but it must first undergo chemical processing for utilization in animals. In humans, this processing comprises β-axial ligand cleavage and Cbl reduction and is
Krams C +8 more
europepmc +2 more sources