Apicortin, a Putative Apicomplexan-Specific Protein, Is Present in Deep-Branching Opisthokonts [PDF]
BiologyApicortin, a tubulin/microtubule-binding protein, was first described in 2009 as a protein characteristic of apicomplexans; it was found to be present in all Apicomplexa genomes already sequenced.
Ferenc Orosz
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Correction: Upregulation of DNA repair genes and cell extrusion underpin the remarkable radiation resistance of Trichoplax adhaerens. [PDF]
PLoS Biology[This corrects the article DOI: 10.1371/journal.pbio.3001471.].
Angelo Fortunato +3 more
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Expression and phylogenetic analysis of the
EvoDevo, 2010 Background zic genes are members of the gli/glis/nkl/zic super-family of C2H2 zinc finger (ZF) transcription factors. Homologs of the zic family have been implicated in patterning neural and mesodermal tissues in bilaterians.
Layden Michael J +4 more
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The hypoxia‐inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens [PDF]
EMBO Reports, 2011 The hypoxic response in humans is mediated by the hypoxia‐inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen‐sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax
Christoph Loenarz +2 more
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Long-term dynamics of placozoan culture: emerging models for population and space biology [PDF]
Frontiers in Cell and Developmental BiologyAs the simplest free-living animal, Trichoplax adhaerens (Placozoa) is emerging as a powerful paradigm to decipher molecular and cellular bases of behavior, enabling integrative studies at all levels of biological organization in the context of metazoan ...
Daria Y. Romanova +6 more
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Coordinated cellular behavior regulated by epinephrine neurotransmitters in the nerveless placozoa [PDF]
Nature CommunicationsUnderstanding how cells communicated before the evolution of nervous systems in early metazoans is key to unraveling the origins of multicellular life.
Minjun Jin +7 more
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Multi-domain O-GlcNAcase structures reveal allosteric regulatory mechanisms [PDF]
Nature CommunicationsNucleocytoplasmic protein O-GlcNAcylation is a dynamic modification catalysed by O-GlcNAc transferase (OGT) and reversed by O-GlcNAc hydrolase (OGA), whose activities are regulated through largely unknown O-GlcNAc-dependent feedback mechanisms.
Sara Basse Hansen +10 more
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Evolution of iGluR ligand specificity, polyamine regulation, and ion selectivity inferred from a placozoan epsilon receptor [PDF]
Communications BiologyEpsilon ionotropic glutamate receptors (iGluRs) are a recently defined clade of neurotransmitter receptors that are found in all major metazoan lineages that are distinct from α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, delta ...
Anhadvir Singh +9 more
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Placozoan secretory cell types implicated in feeding, innate immunity and regulation of behavior. [PDF]
PLoS ONEPlacozoa are millimeter-sized, flat, irregularly shaped ciliated animals that crawl on surfaces in warm oceans feeding on biofilms, which they digest externally. They stand out from other animals due to their simple body plans.
Tatiana D Mayorova +5 more
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Studying Placozoa WBR in the Simplest Metazoan Animal, Trichoplax adhaerens.
Methods Mol Biol, 2022 AbstractPlacozoans are a promising model system to study fundamental regeneration processes in a morphologically and genetically very simple animal. We here provide a brief introduction to the enigmatic Placozoa and summarize the state of the art of animal handling and experimental manipulation possibilities.
Osigus HJ +7 more
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