Results 61 to 70 of about 57,146 (267)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Cannabis Cessation to Address Cannabis Hyperemesis Syndrome: a Plain Language Summary

open access: yes, 2020
Cannabis Hyperemesis Syndrome (CHS) is a condition that involves repeated and severe bouts of nausea and vomiting in individuals with daily, long-term cannabis use.
Newcome, Elle Maureen
core  

Replication Study: Easiness effects in reading the plain language summaries of academic report

open access: yes, 2022
In use of the academic abstracts and the plain language summaries published on Journal of Social and Political Psychology, Kerwer et al.(2021)found undergraduates understood the plain language summaries better and gave them higher scores on the ...
林子渝, Sau-Chin Chen, 張祥偉
core   +1 more source

Perioperative immune-checkpoint inhibitors for muscle-invasive bladder cancer

open access: yesDrugs in Context
Muscle-invasive bladder cancer (MIBC) has a high risk of recurrence following radical cystectomy. Neoadjuvant cisplatin-based chemotherapy has been used for decades to lower recurrence rates but a significant proportion of patients still have disease ...
Albert Jang   +6 more
doaj   +1 more source

Understanding the Burden of Atopic Dermatitis in Africa and the Middle East

open access: yesDermatology and Therapy, 2019
Atopic dermatitis (AD) is a common inflammatory skin disease characterized by intensely pruritic lesions. The prevalence of atopic dermatitis is increasing in developing regions, including Africa and the Middle East.
Khalid Abdullah Mohammad Al-Afif   +7 more
doaj   +1 more source

Weight loss and outcomes in subjects with progressive pulmonary fibrosis: data from the INBUILD trial

open access: yesRespiratory Research, 2023
Plain language summary Patients with worsening fibrosis (scarring) of the lungs may lose weight. This study suggests that the course of disease may be worse in patients who lose weight. Measures to prevent weight loss may be needed in these patients.
Michael Kreuter   +7 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

The views of teenagers with obesity, their caregivers, and doctors: a plain language summary of the ACTION Teens global survey

open access: yesJournal of Comparative Effectiveness Research, 2022
What is this summary about? This is a summary of a research survey called ACTION Teens. In our survey, 12,987 people from 10 countries answered questions about obesity.
Vicki Mooney   +13 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

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