Results 81 to 90 of about 57,146 (267)

Complete response to pembrolizumab in a paediatric patient with Lynch syndrome-associated colorectal cancer: a case report and review of immunotherapy-related bowel obstruction

Drugs in Context
Colorectal cancer (CRC) is extremely rare in paediatrics with aggressive histopathology and advanced presentation. Whilst pembrolizumab has shown efficacy in adult microsatellite instability-high or mismatch repair deficiency CRC, paediatric data remain ...
Antonio Ruggiero, Fernando Fuccillo, Palma Maurizi, Alberto Romano, Dario Talloa, Stefano Mastrangelo, Michele Basso, Vito Briganti, Maria Cristina Giustiniani, Roberto Persiani, Giorgio Attinà   +10 more
doaj   +1 more source

Rational use of inhaled corticosteroids for the treatment of COPD: a plain language summary

Journal of Comparative Effectiveness Research, 2023
What is this summary about? Inhaled corticosteroids (ICS) are a type of medication delivered via an inhaler device that are commonly used in the treatment of asthma.
Amnon Ariel, Peter J Barnes, Tiago Maricoto, Miguel Román-Rodríguez, Andy Powell, Jennifer K Quint   +5 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Portuguese translation - Darolutamide and survival in metastatic, hormone-sensitive prostate cancer: a patient and caregiver perspective and plain language summary of the ARASENS trial

, 2023
Portuguese translation of Darolutamide and survival in metastatic, hormone-sensitive prostate cancer: a patient and caregiver perspective and plain language summary of the ARASENS study 
Matthew R. Smith (848488), Jan Manarite (14585469), David Crawford (13066371), Karim Fizazi (40729), Maha Hussain (15333), Cora N Sternberg (14673534), David Crawford (229134), Karim Fizazi (15093615), Maha Hussain Moalwi (9870878), David Muslin (14585467), Fred Saad (243995), Matthew R Smith (17972079), Matthew R Smith (14972884), Bertrand Tombal (11569049), Cora N. Sternberg (15037641), Thomas Farrington (14585464)   +15 more
core   +1 more source

Long-term effectiveness and safety of ravulizumab in paroxysmal nocturnal hemoglobinuria: a plain language summary

Journal of Comparative Effectiveness Research
What is this summary about? Paroxysmal nocturnal hemoglobinuria (PNH) is a rare disease where red blood cells break apart because they lack certain protective proteins.
Celso Arrais, Natalia Carnelutto, Jheremy Reyes   +2 more
doaj   +1 more source

Role of a topical hydrogel (Dermatix® wound care gel) in acute and chronic wound management: a case series of real-world experiences and expert opinion from Asia

Drugs in Context
Moist wound healing, an established paradigm in the management of wounds, accelerates healing by maintaining an optimal microenvironment. Hydrogels, such as the Dermatix®* Wound Care (DWC) gel, possess fluid-retentive and absorptive properties and ...
Chin Yen Lee, Elizabeth Wei Hsi Chang, Khong Yik Chew, Vilvkumaran Karupayah, Wildan Latief, Vi Anh Le, Dohar Tobing, Thi Phuong Thao Vu, Kean Chew Wong   +8 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Plain language summary of the CheckMate 816 study results: nivolumab plus chemotherapy given before surgery for non–small-cell lung cancer. Japanese translation

, 2023
Japanese translation of:   Plain language summary of the CheckMate 816 study results: nivolumab plus chemotherapy given before surgery for non–small-cell lung ...
Keith Kerr (594418), Tudor–Eliade Ciuleanu (16500961), Fumihiro Tanaka (846846), Everett E. Vokes (15034407), Dimple Pandya (15034725), Shun Lu (402894), Stephen R. Broderick (15054911), Mariano Provencio (15051986), Jonathan Spicer (9418466), Moishe Liberman (4797327), David Balli (371197), Mark Sausen (15054533), Junliang Cai (5152571), Anthony Jarkowski (16500979), Julie R. Brahmer (15054914), Tetsuya Mitsudomi (723473), Enriqueta Felip (286953), Nicolas Girard (15122481), MArk M. Awad (15157423), Gene B Saylors (16500963), Ke-Neng Chen (755260), Christophe Y. Calvet (526904), Janis M. Taube (6178604), Cecile Dorange (16500966), Patrick M. Forde (15054917), Hiroyuki Ito (2899247), Scott J. Swanson (3936971), Changli Wang (15062916), Joseph Fiore (1889509)   +28 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

German translation of Darolutamide and survival in metastatic, hormone-sensitive prostate cancer: a patient and caregiver perspective and plain language summary of the ARASENS trial

, 2023
Geraman translation of  Darolutamide and survival in metastatic, hormone-sensitive prostate cancer: a patient and caregiver perspective and plain language summary of the ARASENS study 
Matthew R. Smith (848488), David Crawford (229134), Jan Manarite (14585469), David Muslin (14585467), Fred Saad (243995), Bertrand Tombal (11569049), Karim Fizazi (40729), Maha Hussain (15333), Cora N Sternberg (14673534), Thomas Farrington (14585464)   +9 more
core   +1 more source